PMID- 3030190
OWN - NLM
STAT- MEDLINE
DCOM- 19870423
LR  - 20061115
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 21
IP  - 2
DP  - 1987 Feb
TI  - Endemic tropical spastic paraparesis associated with human T-lymphotropic virus 
      type I: a clinical and seroepidemiological study of 25 cases.
PG  - 123-30
AB  - Tropical spastic paraparesis (TSP) is a common myeloneuropathy with primary and 
      predominant involvement of the pyramidal tract and minimal sensory loss. The 
      epidemic form of TSP is related to toxic nutritional factors, but the endemic 
      form occurs in clusters in tropical areas, especially in India, Africa, the 
      Seychelles, Colombia, and areas of the Caribbean. We describe the clinical and 
      epidemiological features of 25 TSP patients from Martinique (French West Indies) 
      with serum antibodies to human T-lymphotropic virus type I (HTLV-I). Furthermore, 
      all 11 patients who were seropositive for HTLV-I had specific HTLV-I antibodies 
      in their CSF. All were women. The age of onset varied from 25 to 60 years (mean, 
      45 years). The main clinical features are spastic paraparesis or paraplegia with 
      spasticity of the upper limbs, minimal sensory loss, and bladder dysfunction. 
      Minimal estimated incidence and prevalence are 1 per 100,000 inhabitants per year 
      and 8 per 100,000, respectively. Seventeen percent of the relatives of patients 
      with HTLV-I-associated TSP have HTLV-I antibodies (1 husband and 7 children). In 
      Martinique, the prevalence of HTLV-I antibodies in the general population is 
      about 2% and reaches 10% for neurological disorders other than TSP. Since our 
      initial report, the association between spastic paraparesis and HTLV-I has been 
      confirmed in Jamaica, Colombia, and Japan, suggesting the neurotropism of this 
      lymphotropic human retrovirus.
FAU - Vernant, J C
AU  - Vernant JC
FAU - Maurs, L
AU  - Maurs L
FAU - Gessain, A
AU  - Gessain A
FAU - Barin, F
AU  - Barin F
FAU - Gout, O
AU  - Gout O
FAU - Delaporte, J M
AU  - Delaporte JM
FAU - Sanhadji, K
AU  - Sanhadji K
FAU - Buisson, G
AU  - Buisson G
FAU - de-The, G
AU  - de-The G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/*analysis
MH  - Deltaretrovirus/*immunology
MH  - Female
MH  - HIV/immunology
MH  - Humans
MH  - Male
MH  - Martinique
MH  - Middle Aged
MH  - Muscle Spasticity/epidemiology/immunology
MH  - Paralysis/epidemiology/*immunology
MH  - Serology
EDAT- 1987/02/01 00:00
MHDA- 1987/02/01 00:01
CRDT- 1987/02/01 00:00
PHST- 1987/02/01 00:00 [pubmed]
PHST- 1987/02/01 00:01 [medline]
PHST- 1987/02/01 00:00 [entrez]
AID - 10.1002/ana.410210204 [doi]
PST - ppublish
SO  - Ann Neurol. 1987 Feb;21(2):123-30. doi: 10.1002/ana.410210204.