PMID- 30302129
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 10
DP  - 2018
TI  - Combined effect of glycemic and blood pressure control on diabetic retinopathy 
      among Chinese with type-2 diabetes mellitus.
PG  - 73
LID - 10.1186/s13098-018-0377-7 [doi]
LID - 73
AB  - BACKGROUND: To explore the associations of glycemic and blood pressure (BP) 
      control with diabetic retinopathy (DR), with special focus on whether different 
      combinations of categories of these two interventions are additive. METHODS: A 
      community-based survey including 913 patients with known type-2 diabetes mellitus 
      (T2DM) was conducted in Suzhou, China. Retinal photographs were graded for the 
      presence of DR using the Airlie House classification system. BP and blood 
      hemoglobin A1c (HbA1C) levels were measured by standardized protocols. Binary 
      logistic regression models were established to examine the associations of risk 
      factors with DR. RESULTS: The overall prevalence of any DR was 18.0% [95% 
      confidence interval (95% CI) 15.5-20.6%] in this population. Stratified by 
      conventional control thresholds, lower levels of either systolic blood pressure 
      (SBP, < 140 mmHg) or HbA1C (< 7.0%) were not significantly associated with 
      decreased susceptibility to DR, while patients simultaneously with lower HbA1C 
      and SBP levels demonstrated 43% reduced likelihood of developing DR [adjusted 
      odds ratio (OR) = 0.57, 95% CI 0.33-0.99, P = 0.045)], comparing with those with 
      both higher levels of HbA1C (>/= 7.0%) and SBP (>/= 140 mmHg). Meanwhile, the group 
      achieved intensive HbA1C (< 6.5%) and SBP (< 120 mmHg) control goals were found 
      to have the smallest OR, but failed in yielding statistical significance 
      (P = 0.10). CONCLUSIONS: In this community-based DR screening study of Chinese 
      adults with T2DM, combination but not individual of lower SBP (< 140 mmHg) and 
      HbA1C (< 7.0%) levels, were suggested to be associated with a significantly 
      reduced likelihood of having DR.
FAU - Pan, Chen-Wei
AU  - Pan CW
AD  - 1School of Public Health, Medical College of Soochow University, Suzhou, China. 
      ISNI: 0000 0001 0198 0694. GRID: grid.263761.7
AD  - 2Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric 
      Diseases, Soochow University, Suzhou, China. ISNI: 0000 0001 0198 0694. GRID: 
      grid.263761.7
FAU - Wang, Shan
AU  - Wang S
AD  - 1School of Public Health, Medical College of Soochow University, Suzhou, China. 
      ISNI: 0000 0001 0198 0694. GRID: grid.263761.7
AD  - 2Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric 
      Diseases, Soochow University, Suzhou, China. ISNI: 0000 0001 0198 0694. GRID: 
      grid.263761.7
FAU - Xu, Cai-Lian
AU  - Xu CL
AD  - 3Lixiang Eye Hospital of Soochow University, 200 East Gan Jiang Road, Suzhou, 
      215123 China. ISNI: 0000 0001 0198 0694. GRID: grid.263761.7
AD  - 4Department of Ophthalmology, The First Hospital of Jilin University, Changchun, 
      China. GRID: grid.430605.4
FAU - Song, E
AU  - Song E
AD  - 3Lixiang Eye Hospital of Soochow University, 200 East Gan Jiang Road, Suzhou, 
      215123 China. ISNI: 0000 0001 0198 0694. GRID: grid.263761.7
AD  - 4Department of Ophthalmology, The First Hospital of Jilin University, Changchun, 
      China. GRID: grid.430605.4
LA  - eng
PT  - Journal Article
DEP - 20181001
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC6167778
OTO - NOTNLM
OT  - Blood pressure
OT  - Diabetic retinopathy
OT  - Glucose
OT  - Type-2 diabetes mellitus
EDAT- 2018/10/12 06:00
MHDA- 2018/10/12 06:01
PMCR- 2018/10/01
CRDT- 2018/10/11 06:00
PHST- 2018/08/12 00:00 [received]
PHST- 2018/09/27 00:00 [accepted]
PHST- 2018/10/11 06:00 [entrez]
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2018/10/12 06:01 [medline]
PHST- 2018/10/01 00:00 [pmc-release]
AID - 377 [pii]
AID - 10.1186/s13098-018-0377-7 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2018 Oct 1;10:73. doi: 10.1186/s13098-018-0377-7. 
      eCollection 2018.