PMID- 30302961
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200225
IS  - 2233-6079 (Print)
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
VI  - 42
IP  - 6
DP  - 2018 Dec
TI  - Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 
      Diabetes Mellitus in Japanese Americans.
PG  - 488-495
LID - 10.4093/dmj.2018.0022 [doi]
AB  - BACKGROUND: Skeletal muscle plays a major role in glucose metabolism. We 
      investigated the association between thigh muscle mass, insulin resistance, and 
      incident type 2 diabetes mellitus (T2DM) risk. In addition, we examined the role 
      of body mass index (BMI) as a potential effect modifier in this association. 
      METHODS: This prospective study included 399 Japanese Americans without diabetes 
      (mean age 51.6 years) who at baseline had an estimation of thigh muscle mass by 
      computed tomography and at baseline and after 10 years of follow-up a 75-g oral 
      glucose tolerance test and determination of homeostasis model assessment of 
      insulin resistance (HOMA-IR). We fit regression models to examine the association 
      between thigh muscle area and incidence of T2DM and change in HOMA-IR, both 
      measured over 10 years. RESULTS: Thigh muscle area was inversely associated with 
      future HOMA-IR after adjustment for age, sex, BMI, HOMA-IR, fasting plasma 
      glucose, total abdominal fat area, and thigh subcutaneous fat area at baseline 
      (P=0.033). The 10-year cumulative incidence of T2DM was 22.1%. A statistically 
      significant interaction between thigh muscle area and BMI was observed, i.e., 
      greater thigh muscle area was associated with lower risk of incident T2DM for 
      subjects at lower levels of BMI, but this association diminished at higher BMI 
      levels. CONCLUSION: Thigh muscle mass area was inversely associated with future 
      insulin resistance. Greater thigh muscle area predicts a lower risk of incident 
      T2DM for leaner Japanese Americans.
CI  - Copyright (c) 2018 Korean Diabetes Association.
FAU - Han, Seung Jin
AU  - Han SJ
AUID- ORCID: 0000-0003-4783-6799
AD  - Department of Endocrinology and Metabolism, Ajou University School of Medicine, 
      Suwon, Korea.
AD  - Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care 
      System, Seattle, WA, USA. hsj@ajou.ac.kr.
FAU - Boyko, Edward J
AU  - Boyko EJ
AD  - Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care 
      System, Seattle, WA, USA.
AD  - Department of Medicine, University of Washington School of Medicine, Seattle, WA, 
      USA.
FAU - Kim, Soo Kyung
AU  - Kim SK
AD  - Department of Internal Medicine, CHA Bundang Medical Center, CHA University 
      School of Medicine, Seongnam, Korea.
FAU - Fujimoto, Wilfred Y
AU  - Fujimoto WY
AD  - Department of Medicine, University of Washington School of Medicine, Seattle, WA, 
      USA.
FAU - Kahn, Steven E
AU  - Kahn SE
AD  - Department of Medicine, University of Washington School of Medicine, Seattle, WA, 
      USA.
AD  - Hospital and Specialty Medicine Service, VA Puget Sound Health Care System, 
      Seattle, WA, USA.
FAU - Leonetti, Donna L
AU  - Leonetti DL
AD  - Department of Anthropology, University of Washington, Seattle, WA, USA.
LA  - eng
GR  - HL-49293/National Institutes of Health/
GR  - DK-31170/National Institutes of Health/
GR  - M01 RR000037/RR/NCRR NIH HHS/United States
GR  - RR-000037/General Clinical Research Center/
GR  - R01 DK031170/DK/NIDDK NIH HHS/United States
GR  - P30 DK035816/DK/NIDDK NIH HHS/United States
GR  - DK-035816/Clinical Nutrition Research Unit/
GR  - R01 HL049293/HL/NHLBI NIH HHS/United States
GR  - DK-017047/Diabetes Research Center/
GR  - P30 DK017047/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20180905
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
CIN - Diabetes Metab J. 2019 Feb;43(1):123-124. PMID: 30793553
CIN - Diabetes Metab J. 2019 Feb;43(1):125-126. PMID: 30793554
PMC - PMC6300439
OTO - NOTNLM
OT  - Body mass index
OT  - Diabetes mellitus
OT  - Insulin resistance
OT  - Muscle, skeletal
OT  - Thigh
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2018/10/12 06:00
MHDA- 2018/10/12 06:01
PMCR- 2018/12/01
CRDT- 2018/10/11 06:00
PHST- 2018/01/31 00:00 [received]
PHST- 2018/05/17 00:00 [accepted]
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2018/10/12 06:01 [medline]
PHST- 2018/10/11 06:00 [entrez]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 42.e31 [pii]
AID - 10.4093/dmj.2018.0022 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2018 Dec;42(6):488-495. doi: 10.4093/dmj.2018.0022. Epub 2018 
      Sep 5.