PMID- 30304395
OWN - NLM
STAT- MEDLINE
DCOM- 20200731
LR  - 20200731
IS  - 2058-1742 (Electronic)
IS  - 2058-1742 (Linking)
VI  - 5
IP  - 3
DP  - 2019 Jul 1
TI  - Effect of impaired cardiac conduction after alcohol septal ablation on clinical 
      outcomes: insights from the Euro-ASA registry.
PG  - 252-258
LID - 10.1093/ehjqcco/qcy049 [doi]
AB  - AIMS: We analysed the impact of bundle branch block (BBB) and pacemaker (PM) 
      implantation on symptoms and survival after alcohol septal ablation (ASA) in 
      patients with hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS: Among 1416 
      HCM patients from the Euro-ASA registry, 58 (4%) patients had a PM and 64 (5%) 
      patients had an implantable cardioverter-defibrillator (ICD) before ASA. At 
      latest follow-up (5.0 +/- 4.0 years) after ASA, 118 (8%) patients had an ICD and 
      229 (16%) patients had a PM. In patients without an implantable device prior to 
      ASA 13% had a PM and 5% had an ICD implanted following ASA. New onset BBB was 
      present in 44% (right BBB in 31%) of patients without previous BBB. At latest 
      follow-up, we found no associations between BBB and New York Heart Association 
      (NYHA) Class 3-4 [odds ratio (OR) 0.98, 95% confidence interval (CI) 0.63-1.51; 
      P = 0.91] or Canadian Cardiovascular Society (CCS) Class 3-4 (OR 1.5, CI 
      0.32-6.7; P = 0.62), respectively, and no associations between PM and NYHA Class 
      3-4 (OR 1.2, CI 0.70-2.0; P = 0.52) or CCS 3-4 (OR 1.3, CI 0.24-6.6; P = 0.79), 
      respectively. The survival after ASA was not reduced in patients with BBB [hazard 
      ratio (HR) 0.73, CI 0.53-1.01; P = 0.06] or PM (HR 0.78, CI 0.52-1.17; P = 0.24). 
      CONCLUSIONS: Development of BBB or need for a PM after ASA in patients with 
      obstructive HCM was not associated with inferior symptomatic outcome or reduced 
      survival, thus concerns for the negative impact of impaired cardiac conduction on 
      the clinical outcome after ASA were not confirmed.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.
FAU - Jensen, Morten Kvistholm
AU  - Jensen MK
AD  - Unit for Inherited Cardiac Diseases, Department of Cardiology, Copenhagen 
      University Hospital, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark.
AD  - Department of cardiology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Faber, Lothar
AU  - Faber L
AD  - Clinic for Cardiology, Herz- und Diabeteszentrum NRW, Ruhr-Universitat Bochum, 
      Bad Oeynhausen, Germany.
FAU - Liebregts, Max
AU  - Liebregts M
AD  - Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, the 
      Netherlands.
FAU - Januska, Jaroslav
AU  - Januska J
AD  - Cardiocentre Podlesi, Trinec, Czech Republic.
FAU - Krejci, Jan
AU  - Krejci J
AD  - 1st Department of Internal Medicine/Cardioangiology, International Clinical 
      Research Centre, St. Anne's University Hospital and Masaryk University, Brno, 
      Czech Republic.
FAU - Bartel, Thomas
AU  - Bartel T
AD  - Department of Internal Medicine III, Medical University Innsbruck, Innsbruck, 
      Austria.
AD  - Heart & Vascular Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates.
FAU - Cooper, Robert M
AU  - Cooper RM
AD  - Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest 
      Hospital, Liverpool, England.
FAU - Dabrowski, Maciej
AU  - Dabrowski M
AD  - Department of Interventional Cardiology and Angiology, Institute of Cardiology, 
      Warsaw, Poland.
FAU - Hansen, Peter Riis
AU  - Hansen PR
AD  - Department of Cardiology, Herlev and Gentofte Hospital, Hellerup, Denmark.
FAU - Almaas, Vibeke Marie
AU  - Almaas VM
AD  - Department of Cardiology, Oslo University Hospital, Oslo, Norway.
FAU - Seggewiss, Hubert
AU  - Seggewiss H
AD  - Klinikum Wurzburg-Mitte, Juliusspital, Wurzburg, Germany.
FAU - Horstkotte, Dieter
AU  - Horstkotte D
AD  - Clinic for Cardiology, Herz- und Diabeteszentrum NRW, Ruhr-Universitat Bochum, 
      Bad Oeynhausen, Germany.
FAU - Adlova, Radka
AU  - Adlova R
AD  - Department of Cardiology, 2nd Medical School, Charles University, University 
      Hospital Motol, Prague, Czech Republic.
FAU - Berg, Jurrien Ten
AU  - Berg JT
AD  - Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, the 
      Netherlands.
FAU - Bundgaard, Henning
AU  - Bundgaard H
AD  - Unit for Inherited Cardiac Diseases, Department of Cardiology, Copenhagen 
      University Hospital, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Veselka, Josef
AU  - Veselka J
AD  - Department of Cardiology, 2nd Medical School, Charles University, University 
      Hospital Motol, Prague, Czech Republic.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Heart J Qual Care Clin Outcomes
JT  - European heart journal. Quality of care & clinical outcomes
JID - 101677796
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bundle-Branch Block/*etiology/*therapy
MH  - Cardiomyopathy, Hypertrophic/*therapy
MH  - *Defibrillators, Implantable
MH  - Ethanol/*administration & dosage/*adverse effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Pacemaker, Artificial
MH  - Registries
MH  - Survival Rate
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Alcohol septal ablation
OT  - Bundle branch block
OT  - Cardiac conduction
OT  - Hypertrophic cardiomyopathy
OT  - Implantable cardioverter-defibrillator
OT  - Pacemaker
OT  - Survival
EDAT- 2018/10/12 06:00
MHDA- 2020/08/01 06:00
CRDT- 2018/10/11 06:00
PHST- 2018/08/31 00:00 [received]
PHST- 2018/10/05 00:00 [revised]
PHST- 2018/10/08 00:00 [accepted]
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2020/08/01 06:00 [medline]
PHST- 2018/10/11 06:00 [entrez]
AID - 5124352 [pii]
AID - 10.1093/ehjqcco/qcy049 [doi]
PST - ppublish
SO  - Eur Heart J Qual Care Clin Outcomes. 2019 Jul 1;5(3):252-258. doi: 
      10.1093/ehjqcco/qcy049.