PMID- 30304965
OWN - NLM
STAT- MEDLINE
DCOM- 20190611
LR  - 20200225
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 47
IP  - 2
DP  - 2019 Feb
TI  - Role of Th17-cell related cytokines in geriatric asthma.
PG  - 580-590
LID - 10.1177/0300060518803828 [doi]
AB  - OBJECTIVE: This study aimed to investigate the pathogenesis of geriatric asthma 
      through immunoglobulin E (IgE), interleukin-17A (IL-17A), IL-17F, and 
      glucocorticoid receptor-beta (GR-beta) expression. METHODS: We studied 51 geriatric 
      male patients with asthma and 50 young male patients with asthma. We also 
      included 21 normal geriatric males and 21 normal young males. All geriatric and 
      young patients were divided into groups according to pulmonary function. Levels 
      of cytokines, such as IgE, IL-17A, IL-17F, and GR-beta, were measured. Pulmonary 
      function was assessed. The results from patients were compared with those from 
      the 42 healthy subjects. RESULTS: Serum IgE, IL-17A, IL-17F, and GR-beta levels in 
      geriatric patients with moderate or severe asthma were significantly higher than 
      those in young patients with moderate asthma and in the normal population. 
      Geriatric patients with asthma had higher asthma control test scores than did 
      young patients with asthma. CONCLUSION: Hormone resistance in geriatric male 
      patients with asthma is more serious than that in young male patients with 
      asthma. Airway inflammation and airway remodeling in geriatric male patients with 
      asthma may be more serious than those in young male patients with asthma, even 
      when there is similar pulmonary function.
FAU - Quan-San, Zhang
AU  - Quan-San Z
AD  - Qingdao Municipal Hospital Group Emergency Department, Qingdao, China.
FAU - Xiaohong, Xu
AU  - Xiaohong X
AD  - Qingdao Municipal Hospital Group Emergency Department, Qingdao, China.
FAU - Ying, Li
AU  - Ying L
AD  - Qingdao Municipal Hospital Group Emergency Department, Qingdao, China.
FAU - Zhaojia, Sun
AU  - Zhaojia S
AD  - Qingdao Municipal Hospital Group Emergency Department, Qingdao, China.
LA  - eng
PT  - Journal Article
DEP - 20181010
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Biomarkers)
RN  - 0 (IL17A protein, human)
RN  - 0 (IL17F protein, human)
RN  - 0 (Interleukin-17)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (glucocorticoid receptor beta)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Asthma/*blood/immunology/pathology
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Interleukin-17/*blood
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Receptors, Glucocorticoid/*blood
MH  - Th17 Cells/*immunology
PMC - PMC6381488
OTO - NOTNLM
OT  - Geriatric asthma
OT  - airway remodeling
OT  - glucocorticoid receptor-beta (GR-beta)
OT  - immunoglobulin E (IgE)
OT  - inflammation
OT  - interleukin
EDAT- 2018/10/12 06:00
MHDA- 2019/06/14 06:00
PMCR- 2019/02/01
CRDT- 2018/10/12 06:00
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/10/12 06:00 [entrez]
PHST- 2019/02/01 00:00 [pmc-release]
AID - 10.1177_0300060518803828 [pii]
AID - 10.1177/0300060518803828 [doi]
PST - ppublish
SO  - J Int Med Res. 2019 Feb;47(2):580-590. doi: 10.1177/0300060518803828. Epub 2018 
      Oct 10.