PMID- 30305772
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 0971-6203 (Print)
IS  - 1998-3913 (Electronic)
IS  - 0971-6203 (Linking)
VI  - 43
IP  - 3
DP  - 2018 Jul-Sep
TI  - Voxel based BED and EQD(2) Evaluation of the Radiotherapy Treatment Plan.
PG  - 155-161
LID - 10.4103/jmp.JMP_29_18 [doi]
AB  - INTRODUCTION: Three-dimensional (3D) treatment planning of patient undergoing 
      radiotherapy uses complex and meticulous computational algorithms. These 
      algorithms use 3D voxel data of the patient to calculate the radiation dose 
      distribution and display it over the CT image dataset for treatment plan 
      evaluation. AIMS AND OBJECTIVE: The purpose of the present study is the 
      development and implementation of radiobiological evaluation of the radiotherapy 
      treatment plan incorporating the tissue-specific radiobiological parameters. 
      MATERIAL AND METHOD: An indigenous program was written in MATLAB((R)) software 
      (version 2011b of Mathworks Inc.) to extract the patient treatment plan data from 
      DICOM-RT files which are exported from the treatment planning system. CT-, 
      Structures- and Dose-Cube matrices are reconstructed from the exported patient 
      plan data. BED and EQD(2) based dose volume histograms (DVHs), colorwash and 
      iso-effective dose curves were generated from the physical Dose-Cube using the 
      linear-quadratic (LQ) formalism and tissue-specific radiobiological parameters 
      (alpha/beta). RESULTS AND CONCLUSION: BED-and EQD(2)-colorwash and iso-effective curves 
      along with BED and EQD(2) dose volume histograms provide superior radiobiological 
      information as compared to those of physical doses. This study provides 
      supplementary recipes of radiobiological doses along with the physical doses 
      which are useful for the evaluation of complex radiotherapy treatment plan of the 
      patients.
FAU - Singh, Gaganpreet
AU  - Singh G
AD  - Centre for Medical Physics, Panjab University, Chandigarh, India.
FAU - Oinam, Arun S
AU  - Oinam AS
AD  - Department of Radiotherapy, PGIMER, Chandigarh, India.
FAU - Kamal, Rose
AU  - Kamal R
AD  - Centre for Medical Physics, Panjab University, Chandigarh, India.
FAU - Handa, Bhumika
AU  - Handa B
AD  - Centre for Medical Physics, Panjab University, Chandigarh, India.
FAU - Kumar, Vivek
AU  - Kumar V
AD  - Centre for Medical Physics, Panjab University, Chandigarh, India.
FAU - Rai, Bhavana
AU  - Rai B
AD  - Department of Radiotherapy, PGIMER, Chandigarh, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Med Phys
JT  - Journal of medical physics
JID - 9441104
PMC - PMC6172864
OTO - NOTNLM
OT  - BED-colorwash
OT  - BED-volume histogram
OT  - DVH
OT  - EQD2-colorwash
OT  - EQD2-volume histogram
OT  - iso-BED curve
OT  - iso-EQD2 curve
COIS- There are no conflicts of interest.
EDAT- 2018/10/12 06:00
MHDA- 2018/10/12 06:01
PMCR- 2018/07/01
CRDT- 2018/10/12 06:00
PHST- 2018/10/12 06:00 [entrez]
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2018/10/12 06:01 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - JMP-43-155 [pii]
AID - 10.4103/jmp.JMP_29_18 [doi]
PST - ppublish
SO  - J Med Phys. 2018 Jul-Sep;43(3):155-161. doi: 10.4103/jmp.JMP_29_18.