PMID- 30306243
OWN - NLM
STAT- MEDLINE
DCOM- 20190510
LR  - 20200225
IS  - 1432-1106 (Electronic)
IS  - 0014-4819 (Linking)
VI  - 237
IP  - 1
DP  - 2019 Jan
TI  - Neuromuscular electrical stimulation increases serum brain-derived neurotrophic 
      factor in humans.
PG  - 47-56
LID - 10.1007/s00221-018-5396-y [doi]
AB  - Brain-derived neurotrophic factor (BDNF) plays several important roles in nervous 
      system function including neuronal growth and plasticity. The purpose of the 
      present study was to clarify whether neuromuscular electrical stimulation (NMES) 
      and voluntary exercise to the same integrated force as by the NMES-induced 
      exercise would enhance serum BDNF. Eleven healthy male subjects completed three 
      interventions (NMES, voluntary exercise, and resting interventions) for 20 min on 
      different days. In the NMES intervention, NMES was applied to the quadriceps 
      femoris muscles. The stimulus intensity of NMES was progressively increased to 
      the highest tolerated intensity during the experiment. In the voluntary exercise 
      intervention, subjects performed an isometric knee-extension task; in this 
      intervention, the target torque was calculated in accordance with the integrated 
      force of knee extension obtained during the NMES intervention. In the resting 
      intervention, subjects relaxed in a sitting posture. We measured serum BDNF, 
      blood lactate, heart rate, oxygen uptake, respiratory ratio, and blood pressure. 
      Serum BDNF was increased in the NMES (p = 0.003) and voluntary exercise 
      interventions (p = 0.004) after each intervention. At the post-timepoint, serum 
      BDNF in the NMES intervention was highest among all interventions (p = 0.038) and 
      significantly higher than in the voluntary exercise (p = 0.036) and resting 
      (p = 0.037) interventions. Our results showed that NMES was more effective for 
      enhancing serum BDNF than voluntary exercise at least when employing the same 
      method and integrated force.
FAU - Kimura, Takehide
AU  - Kimura T
AD  - Graduate School of Health Sciences, Sapporo Medical University, W17-S1 Chuo-ku, 
      Sapporo, Hokkaido, 060-8556, Japan.
AD  - Shinoro Orthopedic Hospital, Shinoro 4-5-3-9, Kita-ku, Sapporo, 002-8024, 
      Hokkaido, Japan.
AD  - Department of Physical Therapy, Faculty of Health Sciences, Tsukuba International 
      University, 6-8-33 Manabe, Tsuchiura, 300-0051, Ibaraki, Japan.
FAU - Kaneko, Fuminari
AU  - Kaneko F
AD  - First Division of Physical Therapy, School of Health Sciences, Sapporo Medical 
      University, W17-S1 Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan. f-kaneko@keio.jp.
AD  - Department of Rehabilitation Medicine, Keio University School of Medicine, 35 
      Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. f-kaneko@keio.jp.
AD  - Shonan Keiiku Hospital, 4360 Endo, Fujisawa, Kanagawa, 252-0816, Japan. 
      f-kaneko@keio.jp.
FAU - Iwamoto, Erika
AU  - Iwamoto E
AD  - Second Division of Physical Therapy, School of Health Sciences, Sapporo Medical 
      University, W17-S1 Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan.
FAU - Saitoh, Shigeyuki
AU  - Saitoh S
AD  - Department of Nursing, School of Health Sciences, Sapporo Medical University, 
      W17-S1 Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan.
AD  - Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical 
      University, W17-S1 Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan.
FAU - Yamada, Takashi
AU  - Yamada T
AD  - First Division of Physical Therapy, School of Health Sciences, Sapporo Medical 
      University, W17-S1 Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan.
LA  - eng
GR  - 24650322/Grants-in-Aid for Challenging Exploratory Research/
PT  - Journal Article
DEP - 20181010
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Blood Pressure/physiology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Electric Stimulation/*methods
MH  - Electromyography
MH  - Exercise/physiology
MH  - Female
MH  - Heart Rate/physiology
MH  - Humans
MH  - Isometric Contraction/physiology
MH  - Knee/innervation/physiology
MH  - Lactic Acid/blood
MH  - Male
MH  - Oxygen Consumption
MH  - Quadriceps Muscle/*physiology
MH  - Respiration
MH  - Young Adult
OTO - NOTNLM
OT  - Blood lactate
OT  - Brain-derived neurotrophic factor
OT  - Neuromuscular electrical stimulation
OT  - Voluntary exercise
EDAT- 2018/10/12 06:00
MHDA- 2019/05/11 06:00
CRDT- 2018/10/12 06:00
PHST- 2018/07/11 00:00 [received]
PHST- 2018/10/04 00:00 [accepted]
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2019/05/11 06:00 [medline]
PHST- 2018/10/12 06:00 [entrez]
AID - 10.1007/s00221-018-5396-y [pii]
AID - 10.1007/s00221-018-5396-y [doi]
PST - ppublish
SO  - Exp Brain Res. 2019 Jan;237(1):47-56. doi: 10.1007/s00221-018-5396-y. Epub 2018 
      Oct 10.