PMID- 30306407
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20190111
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 55
IP  - 12
DP  - 2018 Dec
TI  - High prevalence of humoral autoimmunity in first-degree relatives of Mexican type 
      1 diabetes patients.
PG  - 1275-1282
LID - 10.1007/s00592-018-1241-9 [doi]
AB  - AIMS: To assess the prevalence of autoantibodies (Aab) to insulin (IAA), glutamic 
      acid decarboxylase 65 (GADA) and insulinoma antigen 2 (IA-2A), as well as human 
      leukocyte antigen (HLA) class II alleles, in first degree relatives (FDR) of 
      Mexican patients with type 1 diabetes (T1D), and to explore whether these 
      parameters mirror the low incidence of T1D in the Mexican population. METHODS: 
      Aab titers were determined by ELISA in 425 FDR, 234 siblings, 40 offspring and 
      151 parents of 197 patients with T1D. Typing of HLA-DR and -DQ alleles was 
      performed in 41 Aab-positive FDR using polymerase chain reaction with 
      allele-specific oligotyping. RESULTS: Seventy FDR (16.47%) tested positive for 
      Aab. The siblings (19.2%) and the offspring (25%) had significantly higher 
      prevalence of Aab than the parents (9.9%). GADA was the most frequent Aab. Almost 
      half of the Aab-positive FDR had two different Aab (45.7%), and none tested 
      positive for three Aab. The highest prevalence of Aab was found among women in 
      the 15-29 years age group. Moreover, the positivity for two Aab was significantly 
      more frequent among females. A considerable number of FDR (48.8%) carried the 
      susceptible HLA-DR3, -DR4, -DQB1*0201 or -DQB1*0302 alleles, but almost none had 
      the high risk genotype HLA-DR3/DR4. CONCLUSIONS: FDR of Mexican T1D patients have 
      high prevalence of islet Aab, comparable to countries with the highest incidence 
      of T1D. However, Aab positivity does not seem to be associated with HLA risk 
      genotypes, which may have an impact on the low incidence of T1D in Mexico.
FAU - Segovia-Gamboa, Norma C
AU  - Segovia-Gamboa NC
AD  - Department of Molecular Biomedicine, Centro de Investigacion y de Estudios 
      Avanzados del I.P.N. (CINVESTAV-IPN), Av. I.P.N. 2508, San Pedro Zacatenco, 
      07360, Mexico City, Mexico.
FAU - Rodriguez-Arellano, Martha E
AU  - Rodriguez-Arellano ME
AD  - Research Department, Hospital Regional "Licenciado Adolfo Lopez Mateos", ISSSTE, 
      Av. Universidad 1321, Florida, 01030, Mexico City, Mexico.
FAU - Munoz-Solis, Andres
AU  - Munoz-Solis A
AD  - Endocrinology Department, Hospital de Especialidades "Antonio Fraga Mouret", 
      Centro Medico nacional "La Raza" (IMSS), Paseo de las Jacarandas S/N, 
      Atzcapotzalco, 02990, Mexico City, Mexico.
FAU - Retana-Jimenez, Jorge E
AU  - Retana-Jimenez JE
AD  - Pediatrics Department, Hospital Regional "Licenciado Adolfo Lopez Mateos", 
      ISSSTE, Av. Universidad 1321, Florida, 01030, Mexico City, Mexico.
FAU - Vargas-Ayala, German
AU  - Vargas-Ayala G
AD  - Department of Internal Medicine, Ticoman General Hospital, Plan de San Luis S/N, 
      La Purisima Ticoman, 07330, Mexico City, Mexico.
FAU - Granados, Julio
AU  - Granados J
AD  - Division of Immunogenetics, Department of Transplantation, Instituto Nacional de 
      Ciencias Medicas y Nutricion "Salvador Zubiran", Vasco de Quiroga 15, Tlalpan, 
      14080, Mexico City, Mexico.
FAU - Jimenez-Sanchez, Marisela
AU  - Jimenez-Sanchez M
AD  - Endocrinology Department, Hospital de Especialidades "Antonio Fraga Mouret", 
      Centro Medico nacional "La Raza" (IMSS), Paseo de las Jacarandas S/N, 
      Atzcapotzalco, 02990, Mexico City, Mexico.
FAU - Sanchez-Torres, Carmen
AU  - Sanchez-Torres C
AUID- ORCID: 0000-0003-0045-8233
AD  - Department of Molecular Biomedicine, Centro de Investigacion y de Estudios 
      Avanzados del I.P.N. (CINVESTAV-IPN), Av. I.P.N. 2508, San Pedro Zacatenco, 
      07360, Mexico City, Mexico. csanchez@cinvestav.mx.
LA  - eng
GR  - 233290/Fondo Sectorial de Investigacion en Salud y Seguridad Social 
      (SS/IMSS/ISSSTE-CONACYT)/
PT  - Journal Article
DEP - 20181010
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Autoantibodies/*blood/immunology
MH  - Autoimmune Diseases/*blood/*epidemiology/genetics
MH  - Autoimmunity
MH  - Child
MH  - Diabetes Mellitus, Type 1/*blood/*epidemiology/genetics
MH  - *Family
MH  - Female
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - Humans
MH  - Male
MH  - Mexico/epidemiology
MH  - Middle Aged
MH  - Prevalence
MH  - Young Adult
OTO - NOTNLM
OT  - Autoantibodies
OT  - HLA risk genotypes
OT  - Patient relatives
OT  - Type 1 diabetes
EDAT- 2018/10/12 06:00
MHDA- 2019/01/12 06:00
CRDT- 2018/10/12 06:00
PHST- 2018/08/01 00:00 [received]
PHST- 2018/10/03 00:00 [accepted]
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
PHST- 2018/10/12 06:00 [entrez]
AID - 10.1007/s00592-018-1241-9 [pii]
AID - 10.1007/s00592-018-1241-9 [doi]
PST - ppublish
SO  - Acta Diabetol. 2018 Dec;55(12):1275-1282. doi: 10.1007/s00592-018-1241-9. Epub 
      2018 Oct 10.