PMID- 30306527
OWN - NLM
STAT- MEDLINE
DCOM- 20190726
LR  - 20190726
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1099
DP  - 2018
TI  - Involvement of P(2)X(7) Receptors and BDNF in the Pathogenesis of Central 
      Poststroke Pain.
PG  - 211-227
LID - 10.1007/978-981-13-1756-9_18 [doi]
AB  - Central pain is commonly found in patients with neurological complications that 
      are associated with central nervous system insult, such as stroke. It can result 
      directly from central nervous system injury. Impairments in sensory 
      discrimination can make it challenging to differentiate central neuropathic pain 
      from other types of pain or spasticity. Central neuropathic pain may also begin 
      months to years after the injury, further obscuring the recognition of its 
      association with past neurologic injury. This chapter focuses on the involvement 
      of P(2)X(7) receptor and brain-derived neurotrophic factor (BDNF) in central 
      poststroke pain (CPSP). An experimental animal model is introduced that assesses 
      the pathogenesis of central neuropathic pain, and pharmacological approaches and 
      neuromodulatory treatments of this difficult-to-treat pain syndrome are 
      discussed.
FAU - Kuan, Yung-Hui
AU  - Kuan YH
AD  - Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, 
      Taipei, Taiwan.
FAU - Shih, Hsi-Chien
AU  - Shih HC
AD  - Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, 
      Taipei, Taiwan.
FAU - Shyu, Bai-Chuang
AU  - Shyu BC
AD  - Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, 
      Taipei, Taiwan. bmbai@gate.sinica.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Purinergic P2X7)
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Humans
MH  - Neuralgia/*physiopathology
MH  - Receptors, Purinergic P2X7/*physiology
MH  - Stroke/*physiopathology
OTO - NOTNLM
OT  - Anterior cingulate cortex
OT  - Brain-derived neurotropic factor
OT  - Central poststroke pain
OT  - Cytokines
OT  - Medial thalamus
OT  - P2X7 receptor
OT  - Thalamic hemorrhage
EDAT- 2018/10/12 06:00
MHDA- 2019/07/28 06:00
CRDT- 2018/10/12 06:00
PHST- 2018/10/12 06:00 [entrez]
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2019/07/28 06:00 [medline]
AID - 10.1007/978-981-13-1756-9_18 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2018;1099:211-227. doi: 10.1007/978-981-13-1756-9_18.