PMID- 30307340
OWN - NLM
STAT- MEDLINE
DCOM- 20190802
LR  - 20220409
IS  - 1464-5157 (Electronic)
IS  - 0265-6736 (Linking)
VI  - 35
IP  - 1
DP  - 2018
TI  - Magnetic resonance imaging features influencing high-intensity focused ultrasound 
      ablation of adenomyosis with a nonperfused volume ratio of >/=90% as a measure of 
      clinical treatment success: retrospective multivariate analysis.
PG  - 626-636
LID - 10.1080/02656736.2018.1516301 [doi]
AB  - OBJECTIVE: This retrospective study aimed (1) to investigate the magnetic 
      resonance imaging (MRI) features influencing a nonperfused volume ratio 
      (NPVr) >/= 90% after high-intensity focussed ultrasound (HIFU) ablation of 
      adenomyosis, and (2) to assess the safety, which was defined in terms of adverse 
      events (AEs) and changes in anti-Mullerian hormone (AMH) concentrations, and 
      clinical efficacy, which was defined in terms of adenomyosis volume reduction and 
      symptom improvement at 6 months' follow-up. METHODS: Sixty-six women who 
      underwent HIFU treatment were divided into groups A (NPVr >/=90%; n = 26) and B 
      (NPVr <90%, n = 40). Multivariate logistic regression analyses of MRI features 
      were conducted to identify the potential predictors of an NPVr >/=90%. RESULTS: 
      Generalized estimating equation (GEE) analysis was used to model the prediction 
      of an NPVr >/=90% with four significant predictors from multivariate analyses: the 
      thickness of the subcutaneous fat layer, adenomyosis volume, T2 signal intensity 
      (SI) ratio of adenomyosis to myometrium, and the K(trans) ratio of adenomyosis to 
      myometrium. Clinical efficacy was significantly greater in group A than in group 
      B. The findings showed no serious AEs and no significant differences between AMH 
      concentrations before and 6 months after treatment. CONCLUSIONS: The present 
      retrospective study demonstrated that achievement of NPVr >/=90% as a measure of 
      clinical treatment success in MRI-guided HIFU treatment of adenomyosis using 
      multivariate analyses and a prediction model is clinically possible without 
      compromising the safety of patients.
FAU - Keserci, Bilgin
AU  - Keserci B
AD  - a Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia, 
      Kelantan, Malaysia.
AD  - b Hospital Universiti Sains Malaysia, USM 16150 Kubang Kerian, Kelantan, 
      Malaysia.
FAU - Duc, Nguyen Minh
AU  - Duc NM
AD  - c Department of Radiology , Pham Ngoc Thach University of Medicine , Ho Chi Minh 
      City , Viet Nam.
LA  - eng
PT  - Journal Article
DEP - 20181011
PL  - England
TA  - Int J Hyperthermia
JT  - International journal of hyperthermia : the official journal of European Society 
      for Hyperthermic Oncology, North American Hyperthermia Group
JID - 8508395
MH  - Adenomyosis/*surgery
MH  - Adult
MH  - Female
MH  - High-Intensity Focused Ultrasound Ablation/*methods
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Adenomyosis
OT  - clinical efficacy
OT  - high-intensity focussed ultrasound
OT  - magnetic resonance imaging
OT  - nonperfused volume ratio
OT  - prediction model
EDAT- 2018/10/12 06:00
MHDA- 2019/08/03 06:00
CRDT- 2018/10/12 06:00
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2019/08/03 06:00 [medline]
PHST- 2018/10/12 06:00 [entrez]
AID - 10.1080/02656736.2018.1516301 [doi]
PST - ppublish
SO  - Int J Hyperthermia. 2018;35(1):626-636. doi: 10.1080/02656736.2018.1516301. Epub 
      2018 Oct 11.