PMID- 30307757
OWN - NLM
STAT- MEDLINE
DCOM- 20191126
LR  - 20201209
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 41
IP  - 7
DP  - 2019
TI  - Type 2 diabetes with hypertensive patients results in changes to features of 
      adipocytokines: Leptin, Irisin, LGR4, and Sfrp5.
PG  - 645-650
LID - 10.1080/10641963.2018.1529779 [doi]
AB  - The incidence of hypertension and diabetes is increasing, it is reported that 
      adipocytokines might be involved in the pathogenesis of diabetes and 
      hypertension. We aimed to investigate the features of adipocytokines, included of 
      Leptin, Irisin, LGR4, and Sfrp5 in type 2 diabetes mellitus (T2DM) patients with 
      hypertension, simultaneously analyzed the connection of the alteration of 
      adipocytokines with blood pressure and glucose. 424 patients with T2DM and 90 
      healthy subjects were included in the study. The patients with T2DM were divided 
      into 4 groups based on the blood pressure. The levels of adipocytokines (Leptin, 
      Irisin, LGR4, and Sfrp5) were determined by enzyme-linked immunosorbent assay 
      (ELISA). Significantly higher levels of Leptin and lower levels of Irisin, LGR4 
      and Sfrp5 were seen in patients with diabetes compared with non-diabetes 
      (P < 0.05), the mean values of Leptin level was ascending and Irisin, LGR4, and 
      Sfrp5 levels were declining with promoting of blood pressure in hypertension as 
      compared to the non-hypertension with diabetic patients. Multiple stepwise linear 
      regression analysis showed that the concentrations of Leptin, Irisin, Sfrp5, and 
      LGR4 were found to be closely associated with the control of blood pressure and 
      glucose. Conclusion: Four adipocytokines might play different roles and closely 
      relate to the occurrence and development of diabetes and hypertension.
FAU - Li, Baoxin
AU  - Li B
AD  - a Department of Endocrinology, Baoding NO.1 Central Hospital , Baoding , Hebei , 
      China.
AD  - b Hebei Medical University , Shijiazhuang , Hebei , China.
FAU - Yao, Qi
AU  - Yao Q
AD  - a Department of Endocrinology, Baoding NO.1 Central Hospital , Baoding , Hebei , 
      China.
FAU - Guo, Shuqin
AU  - Guo S
AD  - a Department of Endocrinology, Baoding NO.1 Central Hospital , Baoding , Hebei , 
      China.
FAU - Ma, Shuang
AU  - Ma S
AD  - a Department of Endocrinology, Baoding NO.1 Central Hospital , Baoding , Hebei , 
      China.
FAU - Dong, Yuehua
AU  - Dong Y
AD  - a Department of Endocrinology, Baoding NO.1 Central Hospital , Baoding , Hebei , 
      China.
FAU - Xin, Huanhuan
AU  - Xin H
AD  - a Department of Endocrinology, Baoding NO.1 Central Hospital , Baoding , Hebei , 
      China.
FAU - Wang, He
AU  - Wang H
AD  - a Department of Endocrinology, Baoding NO.1 Central Hospital , Baoding , Hebei , 
      China.
FAU - Liu, Lifang
AU  - Liu L
AD  - a Department of Endocrinology, Baoding NO.1 Central Hospital , Baoding , Hebei , 
      China.
FAU - Chang, Wenlong
AU  - Chang W
AD  - a Department of Endocrinology, Baoding NO.1 Central Hospital , Baoding , Hebei , 
      China.
FAU - Zhang, Yunliang
AU  - Zhang Y
AD  - a Department of Endocrinology, Baoding NO.1 Central Hospital , Baoding , Hebei , 
      China.
LA  - eng
PT  - Journal Article
DEP - 20181011
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Adipokines)
RN  - 0 (Blood Glucose)
RN  - 0 (Eye Proteins)
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
RN  - 0 (LGR4 protein, human)
RN  - 0 (Leptin)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (SFRP5 protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Adipokines/*blood
MH  - Adult
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Blood Pressure
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Eye Proteins/blood
MH  - Female
MH  - Fibronectins/blood
MH  - Humans
MH  - Hypertension/complications/*physiopathology
MH  - Leptin/blood
MH  - Male
MH  - Membrane Proteins/blood
MH  - Middle Aged
MH  - Receptors, G-Protein-Coupled/blood
OTO - NOTNLM
OT  - Diabetes
OT  - Irisin
OT  - LGR4
OT  - Leptin
OT  - Sfrp5
OT  - hypertension
EDAT- 2018/10/12 06:00
MHDA- 2019/11/27 06:00
CRDT- 2018/10/12 06:00
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2019/11/27 06:00 [medline]
PHST- 2018/10/12 06:00 [entrez]
AID - 10.1080/10641963.2018.1529779 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2019;41(7):645-650. doi: 10.1080/10641963.2018.1529779. Epub 
      2018 Oct 11.