PMID- 30308049
OWN - NLM
STAT- MEDLINE
DCOM- 20190325
LR  - 20230928
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 10
DP  - 2018
TI  - The TRKB rs2289656 genetic polymorphism is associated with acute suicide attempts 
      in depressed patients: A transversal case control study.
PG  - e0205648
LID - 10.1371/journal.pone.0205648 [doi]
LID - e0205648
AB  - INTRODUCTION: Suicide Attempts (SA) are the main complications of Major 
      Depressive Episodes (MDE) and are difficult to predict. Suicide is associated 
      with the expression of Receptor Tyrosin-Kinase B (TRKB), the receptor of the 
      Brain Derived Neurotrophic Factor (BDNF) involved in MDE. However, the impact of 
      its genetic polymorphisms as predictive factors of SA should be clarified. Our 
      main aim is to assess the association of 8 TRKB genetic polymorphisms and SA in 
      depressed patients. MATERIAL AND METHODS: In 624 patients currently experiencing 
      an MDE in the context of Major Depressive Disorder (MDD) (METADAP study), we 
      assessed the association between 8 TRKB genetic polymorphisms (rs1778933, 
      rs1187352, rs2289658, rs2289657, rs2289656, rs3824519, rs56142442 and rs1439050) 
      and acute (previous month) or past (older than one month) SA. Bonferroni 
      corrections and multivariate analysis adjusted for age, sex, level of education, 
      marital status, Hamilton Depression Rating Scale score and previous MDE were 
      used. RESULTS: The rs2289656 was associated with acute SA (CC = 28.5%, CT = 15.0% 
      and TT = 11.5%, p = 0.0008). However, the other SNPs were not. Patients with the 
      CC genotype had a higher rate of acute SA (28.5%) as compared to T carriers 
      (14.6%) (adjusted OR = 2.2, CI95% [1.4; 3.5], p<0.0001). CONCLUSION: The TRKB 
      rs2289656 CC genotype is associated with a 2.2 fold higher risk of acute SA in 
      depressed patients. If this result could be confirmed, this TRKB SNP may be 
      assessed to contribute to the prediction of SA in depressed patients.
FAU - Deflesselle, Eric
AU  - Deflesselle E
AD  - INSERM UMR_S1178, Equipe "Depression et Antidepresseurs", Faculte de Medecine, 
      CESP, Universite Paris-Sud, Le Kremlin Bicetre, France.
AD  - Departement de Medecine Generale, Universite Paris-Sud, Faculte de Medecine, Le 
      Kremlin Bicetre, France.
FAU - Colle, Romain
AU  - Colle R
AUID- ORCID: 0000-0002-2549-4495
AD  - INSERM UMR_S1178, Equipe "Depression et Antidepresseurs", Faculte de Medecine, 
      CESP, Universite Paris-Sud, Le Kremlin Bicetre, France.
AD  - Service Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hopitaux de 
      Paris, Hopitaux Universitaires Paris-Sud, Hopital de Bicetre, Le Kremlin Bicetre, 
      France.
FAU - Rigal, Laurent
AU  - Rigal L
AD  - Departement de Medecine Generale, Universite Paris-Sud, Faculte de Medecine, Le 
      Kremlin Bicetre, France.
FAU - David, Denis J
AU  - David DJ
AD  - INSERM UMR-S1178, Universite Paris-Sud, Faculte de Pharmacie, CESP, Universite 
      Paris-Saclay, Chatenay-Malabry, France.
FAU - Vievard, Albane
AU  - Vievard A
AD  - INSERM UMR_S1178, Equipe "Depression et Antidepresseurs", Faculte de Medecine, 
      CESP, Universite Paris-Sud, Le Kremlin Bicetre, France.
AD  - Service Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hopitaux de 
      Paris, Hopitaux Universitaires Paris-Sud, Hopital de Bicetre, Le Kremlin Bicetre, 
      France.
FAU - Martin, Severine
AU  - Martin S
AD  - INSERM UMR_S1178, Equipe "Depression et Antidepresseurs", Faculte de Medecine, 
      CESP, Universite Paris-Sud, Le Kremlin Bicetre, France.
AD  - Service Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hopitaux de 
      Paris, Hopitaux Universitaires Paris-Sud, Hopital de Bicetre, Le Kremlin Bicetre, 
      France.
FAU - Becquemont, Laurent
AU  - Becquemont L
AD  - INSERM UMR_S1178, Equipe "Depression et Antidepresseurs", Faculte de Medecine, 
      CESP, Universite Paris-Sud, Le Kremlin Bicetre, France.
AD  - Service de Genetique Moleculaire, Pharmacogenetique et Hormonologie, Assistance 
      Publique-Hopitaux de Paris, Hopitaux Universitaires Paris-Sud, Hopital de 
      Bicetre, Le Kremlin Bicetre, France.
FAU - Verstuyft, Celine
AU  - Verstuyft C
AD  - INSERM UMR_S1178, Equipe "Depression et Antidepresseurs", Faculte de Medecine, 
      CESP, Universite Paris-Sud, Le Kremlin Bicetre, France.
AD  - Service de Genetique Moleculaire, Pharmacogenetique et Hormonologie, Assistance 
      Publique-Hopitaux de Paris, Hopitaux Universitaires Paris-Sud, Hopital de 
      Bicetre, Le Kremlin Bicetre, France.
AD  - Centre de Ressources Biologiques Paris Sud, Hopital Bicetre, Assistance 
      Publique-Hopitaux de Paris, Le Kremlin Bicetre, France.
FAU - Corruble, Emmanuelle
AU  - Corruble E
AD  - INSERM UMR_S1178, Equipe "Depression et Antidepresseurs", Faculte de Medecine, 
      CESP, Universite Paris-Sud, Le Kremlin Bicetre, France.
AD  - Service Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hopitaux de 
      Paris, Hopitaux Universitaires Paris-Sud, Hopital de Bicetre, Le Kremlin Bicetre, 
      France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181011
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Membrane Glycoproteins)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (tropomyosin-related kinase-B, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Depressive Disorder, Major/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*genetics/physiology
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Receptor, trkB/*genetics/physiology
MH  - *Suicide, Attempted
MH  - Young Adult
PMC - PMC6181406
COIS- Eric Deflesselle, Romain Colle, Laurent Rigal, Celine Verstuyft, Albane Vievard, 
      Severine Martin, Emmanuelle Corruble have no conflict of interest to disclose. 
      Denis Joseph David currently receives investigator-initiated research support 
      from Lundbeck and served as a consultant in the areas of target identification, 
      validation and new compound development to Lundbeck Inc., Roche and Servier. 
      Laurent Becquemont was an investigator for Antisense Therapeutics, Alnylam 
      Pharmaceuticals, Alexion, Actelion, Auris Medical, Gilead Sciences, Ionis 
      Pharmaceuticals, MedDay Pharma, Novartis, PregLem SA, Ultragenix Pharmaceutical. 
      He received consulting fees from Sanofi-Aventis, Pfizer, Kyowa Kirin and Servier, 
      lecture fees from Genzyme, GlaxoSmithKline, Bristol-Myers Squibb, Merck Sharp and 
      Dohme; a close family member works at Sanofi France. This does not alter our 
      adherence to PLOS ONE policies on sharing data and materials
EDAT- 2018/10/12 06:00
MHDA- 2019/03/26 06:00
PMCR- 2018/10/11
CRDT- 2018/10/12 06:00
PHST- 2018/05/29 00:00 [received]
PHST- 2018/09/29 00:00 [accepted]
PHST- 2018/10/12 06:00 [entrez]
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2019/03/26 06:00 [medline]
PHST- 2018/10/11 00:00 [pmc-release]
AID - PONE-D-18-16098 [pii]
AID - 10.1371/journal.pone.0205648 [doi]
PST - epublish
SO  - PLoS One. 2018 Oct 11;13(10):e0205648. doi: 10.1371/journal.pone.0205648. 
      eCollection 2018.