PMID- 30308201
OWN - NLM
STAT- MEDLINE
DCOM- 20191121
LR  - 20191121
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 198
DP  - 2019 Feb
TI  - Progression of Diabetic Microaneurysms According to the Internal Reflectivity on 
      Structural Optical Coherence Tomography and Visibility on Optical Coherence 
      Tomography Angiography.
PG  - 8-16
LID - S0002-9394(18)30573-7 [pii]
LID - 10.1016/j.ajo.2018.09.031 [doi]
AB  - PURPOSE: To investigate the progression of diabetic microaneurysms (MAs) 
      according to the spectral-domain optical coherence tomography (SD-OCT) and OCT 
      angiography (OCTA) characteristics and to evaluate their influence on the retinal 
      extracellular fluid accumulation at 1 year follow-up in patients with 
      nonproliferative diabetic retinopathy (NPDR). DESIGN: Prospective, observational 
      case series. METHODS: Fourteen patients with NPDR underwent SD-OCT and OCTA at 
      the baseline and at 1 year follow-up. For all the selected MAs the visibility, 
      the changes of internal reflectivity, graded as hyporeflective, moderate, or 
      hyperreflective, and the extracellular fluid accumulation surrounding each MA on 
      SD-OCT at 1 year were evaluated. The changes in terms of visualization at the 
      level either of superficial (SCP) or deep (DCP) capillary plexus and the presence 
      of flow on the corresponding OCTA scan at 1 year were evaluated. RESULTS: Of 127 
      MAs selected at the baseline, 89 (70%) were still visible on SD-OCT at 1 year. 
      The reflectivity pattern at baseline was strongly associated with extracellular 
      fluid accumulation at 1 year, with 18% of hyporeflective vs 66% of 
      hyperreflective MAs developing extracellular fluid (P = .004). Among OCTA 
      findings, the presence of flow (P = .001), the visibility (P < .001), and the 
      deep location (DCP or both DCP and SCP, P = .007) were strongly associated with 
      the development of extracellular fluid at 12 months. CONCLUSIONS: This study 
      suggests an association between the SD-OCT and OCTA characteristics of diabetic 
      MAs and the retinal extracellular fluid accumulation at 1 year. A better 
      interpretation of MA characteristics could improve the timing and the management 
      of diabetic maculopathy.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Parravano, Mariacristina
AU  - Parravano M
AD  - IRCCS - Fondazione Bietti, Rome, Italy.
FAU - De Geronimo, Daniele
AU  - De Geronimo D
AD  - IRCCS - Fondazione Bietti, Rome, Italy.
FAU - Scarinci, Fabio
AU  - Scarinci F
AD  - IRCCS - Fondazione Bietti, Rome, Italy.
FAU - Virgili, Gianni
AU  - Virgili G
AD  - Department of Translational Surgery and Medicine, Eye Clinic, University of 
      Florence, Florence, Italy.
FAU - Querques, Lea
AU  - Querques L
AD  - Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, 
      Italy.
FAU - Varano, Monica
AU  - Varano M
AD  - IRCCS - Fondazione Bietti, Rome, Italy.
FAU - Bandello, Francesco
AU  - Bandello F
AD  - Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, 
      Italy.
FAU - Querques, Giuseppe
AU  - Querques G
AD  - Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, 
      Italy. Electronic address: giuseppe.querques@hotmail.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181009
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/complications
MH  - Diabetic Retinopathy/*diagnosis/diagnostic imaging
MH  - Disease Progression
MH  - Extracellular Fluid
MH  - Exudates and Transudates
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Microaneurysm/*diagnosis/diagnostic imaging
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Vessels/*diagnostic imaging
MH  - Subretinal Fluid
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity/physiology
EDAT- 2018/10/12 06:00
MHDA- 2019/11/22 06:00
CRDT- 2018/10/12 06:00
PHST- 2018/08/03 00:00 [received]
PHST- 2018/09/23 00:00 [revised]
PHST- 2018/09/26 00:00 [accepted]
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2019/11/22 06:00 [medline]
PHST- 2018/10/12 06:00 [entrez]
AID - S0002-9394(18)30573-7 [pii]
AID - 10.1016/j.ajo.2018.09.031 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2019 Feb;198:8-16. doi: 10.1016/j.ajo.2018.09.031. Epub 2018 Oct 
      9.