PMID- 30308512
OWN - NLM
STAT- MEDLINE
DCOM- 20191112
LR  - 20221207
IS  - 1421-9697 (Electronic)
IS  - 0250-6807 (Linking)
VI  - 73
IP  - 4
DP  - 2018
TI  - Reduced Serum Levels of Brain-Derived Neurotrophic Factor Are Related to Mild 
      Cognitive Impairment in Chinese Patients with Type 2 Diabetes Mellitus.
PG  - 271-281
LID - 10.1159/000493275 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is involved in obesity, type 
      2 diabetes mellitus (T2DM), and cognitive dysfunction. The present study sought 
      to assess the role of serum levels of BDNF in the pathophysiological process of 
      mild cognitive impairment (MCI), a preclinical phase of dementia in 715 Chinese 
      patients with T2DM. METHODS: Cross-sectional data were obtained from 715 patients 
      with T2DM recruited from a Chinese diabetes center. Serum levels of BDNF were 
      measured with sandwich enzyme-linked immunosorbent assay. The influence of BDNF 
      on MCI was examined using univariate and multivariate binary logistic regression 
      analyses. RESULTS: In univariate and multivariate logistic regression analyses, 
      for each one-unit increase of BDNF, the unadjusted and adjusted risk of MCI 
      decreased by 9% (OR 0.91; 95% CI 0.88-0.93, p < 0.001) and 6% (0.94; 0.87-0.98, p 
      < 0.001) respectively. In multivariate models comparing the first (Q1), second 
      and third quartiles against the fourth quartile of BDNF, BDNF in Q1 and Q2 were 
      associated with MCI, and increased risk of MCI by 275% (OR 3.75; 95% CI 
      2.38-6.03) and 155% (2.55; 1.32-4.02). These results suggested that for each 1 
      ng/mL increase of serum level of BDNF, the association became stronger among 
      obese diabetic patients (OR 0.91, 95% CI 0.85-0.96; p < 0.001) versus nonobese 
      diabetic patients (OR 0.95, 95% CI 0.86-0.98; p = 0.001). CONCLUSION: The present 
      data demonstrated that reduced serum levels of BDNF were associated with 
      increased risk of MCI and might be useful for identifying diabetic patients at 
      risk of dementia for early prevention strategies.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Sun, Zhi-Chun
AU  - Sun ZC
AD  - Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
FAU - Yu, Jing
AU  - Yu J
AD  - Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
FAU - Liu, Yi-Lan
AU  - Liu YL
AD  - Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
FAU - Hong, Zhen-Zhen
AU  - Hong ZZ
AD  - Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
FAU - Ling, Lin
AU  - Ling L
AD  - Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
FAU - Li, Guo-Qian
AU  - Li GQ
AD  - Department of Neurology, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
FAU - Zhuo, Ya-Fen
AU  - Zhuo YF
AD  - Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
FAU - Wang, Wan-Ru
AU  - Wang WR
AD  - Department of Cardiology, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, ChinaWangzrqzmu@126.com.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181011
PL  - Switzerland
TA  - Ann Nutr Metab
JT  - Annals of nutrition & metabolism
JID - 8105511
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Asian People
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - China
MH  - Cognitive Dysfunction/*blood/etiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood/complications
MH  - Risk Factors
OTO - NOTNLM
OT  - Mild cognitive impairment
OT  - Brain-derived neurotrophic factor
OT  - Type 2 diabetes mellitus 
EDAT- 2018/10/12 06:00
MHDA- 2019/11/13 06:00
CRDT- 2018/10/12 06:00
PHST- 2018/06/27 00:00 [received]
PHST- 2018/08/27 00:00 [accepted]
PHST- 2018/10/12 06:00 [pubmed]
PHST- 2019/11/13 06:00 [medline]
PHST- 2018/10/12 06:00 [entrez]
AID - 000493275 [pii]
AID - 10.1159/000493275 [doi]
PST - ppublish
SO  - Ann Nutr Metab. 2018;73(4):271-281. doi: 10.1159/000493275. Epub 2018 Oct 11.