PMID- 30309292
OWN - NLM
STAT- MEDLINE
DCOM- 20200911
LR  - 20200911
IS  - 1525-1489 (Electronic)
IS  - 0885-0666 (Linking)
VI  - 34
IP  - 11-12
DP  - 2019 Nov-Dec
TI  - The ART of Antiretroviral Therapy in Critically Ill Patients With HIV.
PG  - 897-909
LID - 10.1177/0885066618803871 [doi]
AB  - The management of patients with human immunodeficiency virus (HIV) can be a 
      complicated specialty within itself, made even more complex when there are so 
      many unanswered questions regarding the care of critically ill patients with HIV. 
      The lack of consensus on the use of antiretroviral medications in the critically 
      ill patient population has contributed to an ongoing clinical debate among 
      intensivists. This review focuses on the pharmacological complications of 
      antiretroviral therapy (ART) in the intensive care setting, specifically the 
      initiation of ART in patients newly diagnosed with HIV, immune reconstitution 
      inflammatory syndrome (IRIS), continuation of ART in those who were on a complete 
      regimen prior to intensive care unit admission, barriers of drug delivery 
      alternatives, and drug-drug interactions.
FAU - Finocchio, Tyler
AU  - Finocchio T
AD  - Avera McKennan Hospital & University Health Center, Sioux Falls, SD, USA.
FAU - Coolidge, William
AU  - Coolidge W
AD  - Avera McKennan Hospital & University Health Center, Sioux Falls, SD, USA.
FAU - Johnson, Thomas
AU  - Johnson T
AD  - Avera McKennan Hospital & University Health Center, Sioux Falls, SD, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181011
PL  - United States
TA  - J Intensive Care Med
JT  - Journal of intensive care medicine
JID - 8610344
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Critical Care/*methods
MH  - Critical Illness/*therapy
MH  - HIV
MH  - HIV Infections/complications/*drug therapy/virology
MH  - Hospitalization
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/complications/*drug therapy/virology
MH  - Intensive Care Units
MH  - Risk Factors
OTO - NOTNLM
OT  - acquired immune deficiency syndrome
OT  - antiretroviral
OT  - drug delivery
OT  - human immunodeficiency virus
OT  - immune reconstitution inflammatory syndrome
OT  - intensive care unit
EDAT- 2018/10/13 06:00
MHDA- 2020/09/12 06:00
CRDT- 2018/10/13 06:00
PHST- 2018/10/13 06:00 [pubmed]
PHST- 2020/09/12 06:00 [medline]
PHST- 2018/10/13 06:00 [entrez]
AID - 10.1177/0885066618803871 [doi]
PST - ppublish
SO  - J Intensive Care Med. 2019 Nov-Dec;34(11-12):897-909. doi: 
      10.1177/0885066618803871. Epub 2018 Oct 11.