PMID- 30310890
OWN - NLM
STAT- MEDLINE
DCOM- 20190221
LR  - 20190221
IS  - 2047-4849 (Electronic)
IS  - 2047-4830 (Linking)
VI  - 6
IP  - 12
DP  - 2018 Nov 20
TI  - A polyhedral oligomeric silsesquioxane/molecular sieve codoped molecularly 
      imprinted polymer for gastroretentive drug-controlled release in vivo.
PG  - 3170-3177
LID - 10.1039/c8bm01124a [doi]
AB  - Flotation drug delivery system (FDDS) is recognized as an efficient means to 
      improve the therapeutic efficiency and enhance the drug bioavailability. Herein, 
      we have developed a molecularly imprinted polymer (MIP) against capecitabine 
      (CAP) to fabricate a FDDS by exploiting polyhedral oligomeric silsesquioxane 
      (POSS) and Mobil composition of matter no. 41 (MCM-41) as the codopant. The 
      synergistic effect of POSS and MCM-41 endows MIPs with enhanced imprinting effect 
      and improved mass transfer efficiency. The impacts of the type of dopant, the 
      type of functional monomer, the template/functional monomer ratio and the 
      functional monomer/cross-linker ratio on imprinting effect have been investigated 
      in detail. The POSS/MCM-41 codoped MIPs present favourable sustained release 
      property in vitro and in vivo, displaying a high relative bioavailability of 
      173.4%. The proposed MIPs with high selectivity and superior physical and 
      chemical stability exhibit potential as an alternative drug carrier applied in 
      FDDS.
FAU - Wang, Xu
AU  - Wang X
AD  - Tianjin Key Laboratory on Technologies Enabling Development of Clinical 
      Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical 
      University, Tianjin 300070, PR China. huangyp100@163.com zhaoshengliu@sohu.com.
FAU - Yang, Fang-Fang
AU  - Yang FF
FAU - Zhang, Li-Ping
AU  - Zhang LP
FAU - Huang, Yan-Ping
AU  - Huang YP
FAU - Liu, Zhao-Sheng
AU  - Liu ZS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biomater Sci
JT  - Biomaterials science
JID - 101593571
RN  - 0 (Drug Carriers)
RN  - 0 (MCM-41)
RN  - 0 (Organosilicon Compounds)
RN  - 0 (polyhedraloligosilsesquioxane)
RN  - 6804DJ8Z9U (Capecitabine)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Capecitabine/administration & dosage/pharmacokinetics
MH  - Drug Carriers/chemistry
MH  - *Drug Liberation
MH  - Male
MH  - *Molecular Imprinting
MH  - Organosilicon Compounds/*chemistry
MH  - Rats
MH  - Rats, Wistar
MH  - Silicon Dioxide/chemistry
EDAT- 2018/10/13 06:00
MHDA- 2019/02/23 06:00
CRDT- 2018/10/13 06:00
PHST- 2018/10/13 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2018/10/13 06:00 [entrez]
AID - 10.1039/c8bm01124a [doi]
PST - ppublish
SO  - Biomater Sci. 2018 Nov 20;6(12):3170-3177. doi: 10.1039/c8bm01124a.