PMID- 30311825
OWN - NLM
STAT- MEDLINE
DCOM- 20190122
LR  - 20221207
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 21
IP  - 12
DP  - 2018 Dec
TI  - Effects of alpha-Lipoic Acid, Carnosine, and Thiamine Supplementation in Obese 
      Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study.
PG  - 1197-1203
LID - 10.1089/jmf.2018.0007 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is evolving to an epidemic of the modern world. 
      T2DM is associated with a number of pathological complications, including 
      cardiovascular disease that is mostly promoted by the increased oxidative stress 
      in type 2 diabetic patients. We performed a randomized double-blind 
      placebo-controlled trial to investigate the effectiveness of an individualized 
      oral supplementation with alpha-lipoic acid (ALA), carnosine, and thiamine. For that 
      purpose, 82 obese type 2 diabetic patients were randomly assigned to 2 groups, 
      and were either supplemented daily with 7 mg ALA/kg body weight, 6 mg 
      carnosine/kg body weight, and 1 mg thiamine/kg body weight or placebo for 8 
      weeks. An array of biochemical tests including the estimation of oxidative stress 
      and platelet aggregation were performed at baseline and at follow-up. Moreover, 
      the antiplatelet activity of each of the supplement's components was determined 
      ex vivo at human and washed rabbit platelets. Glucose and HbA(1c) levels were 
      significantly reduced after supplementation (135.7 +/- 19.5 mg/dL vs. 
      126.5 +/- 16.8 mg/dL and 8.3% +/- 0.3% vs. 6.03% +/- 0.58%, respectively, P < .05); 
      however, insulin was significantly increased (3.6 +/- 0.7 muIU/mL vs. 
      6.8 +/- 0.2 muIU/mL, P < .05). The patients treated with the supplement recorded 
      higher follow-up values for HOMA-IR and HOMA-beta, and a significant drop in serum 
      hydroperoxide level. Only ALA inhibited platelets aggregation ex vivo through 
      ADP, platelet activating factor, arachidonic acid, epinephrine, collagen, and 
      thrombin pathways. Daily supplementation with an individualized ALA, carnosine, 
      and thiamine supplement effectively reduced glucose concentration in type 2 
      diabetic patients, probably by increasing insulin production from the pancreas. 
      In addition to that, the reduction of oxidative stress and inhibition of platelet 
      aggregation could potentially provide greater cardiovascular protection. Further 
      studies are needed to fine-tune the supplementation dose-response effects in T2DM 
      patients.
FAU - Karkabounas, Spyridon
AU  - Karkabounas S
AD  - 1 Department of Physiology, Faculty of Medicine, School of Health Sciences; 
      Medical Department; University of Ioannina , Ioannina, Greece .
FAU - Papadopoulos, Nikolaos
AU  - Papadopoulos N
AD  - 1 Department of Physiology, Faculty of Medicine, School of Health Sciences; 
      Medical Department; University of Ioannina , Ioannina, Greece .
FAU - Anastasiadou, Chryssa
AU  - Anastasiadou C
AD  - 2 Hellenic Agricultural Organization, Fisheries Research Institute , Kavala, 
      Greece .
FAU - Gubili, Chrysoula
AU  - Gubili C
AD  - 2 Hellenic Agricultural Organization, Fisheries Research Institute , Kavala, 
      Greece .
FAU - Peschos, Dimitrios
AU  - Peschos D
AD  - 1 Department of Physiology, Faculty of Medicine, School of Health Sciences; 
      Medical Department; University of Ioannina , Ioannina, Greece .
FAU - Daskalou, Telemachos
AU  - Daskalou T
AD  - 3 Department of Haematology, Sismanogleio Hospital , Athens, Greece .
FAU - Fikioris, Nikolaos
AU  - Fikioris N
AD  - 1 Department of Physiology, Faculty of Medicine, School of Health Sciences; 
      Medical Department; University of Ioannina , Ioannina, Greece .
FAU - Simos, Yannis V
AU  - Simos YV
AD  - 1 Department of Physiology, Faculty of Medicine, School of Health Sciences; 
      Medical Department; University of Ioannina , Ioannina, Greece .
FAU - Kontargiris, Evangelos
AU  - Kontargiris E
AD  - 1 Department of Physiology, Faculty of Medicine, School of Health Sciences; 
      Medical Department; University of Ioannina , Ioannina, Greece .
AD  - 4 Department of Nursing, Epirus Institute of Technology (T.E.I. of Epirus) , 
      Ioannina, Greece .
FAU - Gianakopoulos, Xenophon
AU  - Gianakopoulos X
AD  - 5 Department of Urology, University Hospital of Ioannina , Ioannina, Greece .
FAU - Ragos, Vasilios
AU  - Ragos V
AD  - 6 Clinic of Maxillofacial Surgery, Medical Department; University of Ioannina , 
      Ioannina, Greece .
FAU - Chatzidimitriou, Maria
AU  - Chatzidimitriou M
AD  - 7 Medical Laboratories, Alexander Technological Institute of Thessaloniki , 
      Thessaloniki, Greece .
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20181011
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - 8HO6PVN24W (Carnosine)
RN  - X66NSO3N35 (Thiamine)
SB  - IM
MH  - Administration, Oral
MH  - Blood Glucose/metabolism
MH  - Carnosine/administration & dosage/therapeutic use
MH  - Diabetes Mellitus, Type 2/blood/*prevention & control
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Obesity, Morbid
MH  - Surveys and Questionnaires
MH  - Thiamine/administration & dosage/therapeutic use
MH  - Thioctic Acid/administration & dosage/therapeutic use
MH  - Treatment Outcome
EDAT- 2018/10/13 06:00
MHDA- 2019/01/23 06:00
CRDT- 2018/10/13 06:00
PHST- 2018/10/13 06:00 [pubmed]
PHST- 2019/01/23 06:00 [medline]
PHST- 2018/10/13 06:00 [entrez]
AID - 10.1089/jmf.2018.0007 [doi]
PST - ppublish
SO  - J Med Food. 2018 Dec;21(12):1197-1203. doi: 10.1089/jmf.2018.0007. Epub 2018 Oct 
      11.