PMID- 30311868
OWN - NLM
STAT- MEDLINE
DCOM- 20200114
LR  - 20200114
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 41
IP  - 1
DP  - 2019 Jan
TI  - Effect of regular swimming exercise to duration-intensity on neurocognitive 
      function in cerebral infarction rat model.
PG  - 37-44
LID - 10.1080/01616412.2018.1524087 [doi]
AB  - Objective: This study investigated the effect of regular swimming exercise 
      according to the duration-intensity on neurocognitive function in a cerebral 
      infarction rat model. Methods: Forty male Sprague-Dawley 10-week-old rats, 
      weighing 300 +/- 50 g, were subjected to photothrombotic cerebral infarction. The 
      remaining 36 rats were randomly divided into four groups (n = 9 per group: 
      non-exercise (group A); swimming exercise of short duration-intensity (5 min/day, 
      group B); swimming exercise of moderate duration-intensity (10 min/day, group C); 
      and swimming exercise of long duration-intensity (20 min/day, group D). Exercise 
      was performed five times a week for 4 weeks, beginning the day after cerebral 
      infarction. Neurocognitive function was evaluated with the Morris water maze 
      test. Immunohistochemistry and western blot analysis examined brain-derived 
      neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) at 4 
      weeks postinfarction. Results: At 4 weeks postinfarction, escape latency was 
      found to be shorter in group C than in any of groups A, B, or D. 
      Immunohistochemistry revealed the most significant immunoreactivity for BDNF and 
      VEGF in group C. Western blot analysis demonstrated that BDNF and VEGF proteins 
      were markedly expressed in group C. Conclusions: Regular swimming exercise of 
      moderate duration-intensity may be the most effective exercise protocol for the 
      recovery of neurocognitive function in cerebral infarction rat model.
FAU - Song, Min-Keun
AU  - Song MK
AUID- ORCID: 0000-0001-8186-5345
AD  - a Department of Physical & Rehabilitation Medicine , Chonnam National University 
      Hospital & Medical School , Gwangju , Republic of Korea.
FAU - Kim, Eun-Jong
AU  - Kim EJ
AUID- ORCID: 0000-0001-9527-9320
AD  - a Department of Physical & Rehabilitation Medicine , Chonnam National University 
      Hospital & Medical School , Gwangju , Republic of Korea.
FAU - Kim, Jung-Kook
AU  - Kim JK
AUID- ORCID: 0000-0002-8800-086X
AD  - a Department of Physical & Rehabilitation Medicine , Chonnam National University 
      Hospital & Medical School , Gwangju , Republic of Korea.
FAU - Park, Hyeng-Kyu
AU  - Park HK
AD  - a Department of Physical & Rehabilitation Medicine , Chonnam National University 
      Hospital & Medical School , Gwangju , Republic of Korea.
FAU - Lee, Sam-Gyu
AU  - Lee SG
AD  - a Department of Physical & Rehabilitation Medicine , Chonnam National University 
      Hospital & Medical School , Gwangju , Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20181012
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (vascular endothelial growth factor A, rat)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cerebral Infarction/*metabolism/pathology/psychology/*therapy
MH  - Cognition/*physiology
MH  - Disease Models, Animal
MH  - *Exercise Therapy
MH  - Hippocampus/*metabolism/pathology
MH  - Male
MH  - Maze Learning/physiology
MH  - Random Allocation
MH  - Rats, Sprague-Dawley
MH  - Swimming/*physiology/psychology
MH  - Vascular Endothelial Growth Factor A/metabolism
OTO - NOTNLM
OT  - Cerebral infarction
OT  - cognition
OT  - exercise intensity
OT  - recovery
OT  - swimming
EDAT- 2018/10/13 06:00
MHDA- 2020/01/15 06:00
CRDT- 2018/10/13 06:00
PHST- 2018/10/13 06:00 [pubmed]
PHST- 2020/01/15 06:00 [medline]
PHST- 2018/10/13 06:00 [entrez]
AID - 10.1080/01616412.2018.1524087 [doi]
PST - ppublish
SO  - Neurol Res. 2019 Jan;41(1):37-44. doi: 10.1080/01616412.2018.1524087. Epub 2018 
      Oct 12.