PMID- 30312481
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20190215
IS  - 1099-0801 (Electronic)
IS  - 0269-3879 (Linking)
VI  - 33
IP  - 1
DP  - 2019 Jan
TI  - Synthesis of magnetic nanoparticle-based molecularly imprinted polymer as a 
      selective sorbent for efficient extraction of ezetimibe from biological samples.
PG  - e4404
LID - 10.1002/bmc.4404 [doi]
AB  - In the present study, a novel and efficient adsorbent constructed of molecularly 
      imprinted polymer on the surface of modified magnetic nanoparticles with oleic 
      acid (MNPs) was applied for the selective extraction of ezetimibe. The magnetic 
      molecularly imprinted polymer (MMIP) was polymerized at the surface of modified 
      MNPs using methacrylic acid as functional monomer, ezetimibe as template and 
      ethylene glycol dimethacrylate as cross-linker. The resulting MMIP showed high 
      adsorption capacity, good selectivity and fast kinetic binding for the template 
      molecule. It was characterized by Fourier transform infrared analysis, scanning 
      electron microscopy and transmission electron microscopy methods. The maximum 
      adsorption capacity of MMIP was obtained as 137.1 mg g(-1) and it took about 
      20 min to achieve the equilibrium state. The adsorption model of the adsorbent 
      was fitted with the Freundlich and Langmuir isotherm equations. The assay 
      exhibited a linear range of 0.003-20.000 mg L(-1) for ezetimibe with a 
      correlation coefficient of 0.995. The relative standard deviations for the 
      recoveries were <5.2. The method was also examined for the analysis of ezetimibe 
      in the biological samples.
CI  - (c) 2018 John Wiley & Sons, Ltd.
FAU - Peyrovi, Moazameh
AU  - Peyrovi M
AD  - Department of Chemistry, University of Mazandaran, Babolsar, Iran.
FAU - Hadjmohammadi, Mohammadreza
AU  - Hadjmohammadi M
AUID- ORCID: 0000-0002-7094-3851
AD  - Department of Chemistry, University of Mazandaran, Babolsar, Iran.
FAU - Saeidi, Iman
AU  - Saeidi I
AD  - Iranian National Standards Organization.
LA  - eng
PT  - Journal Article
DEP - 20181203
PL  - England
TA  - Biomed Chromatogr
JT  - Biomedical chromatography : BMC
JID - 8610241
RN  - 0 (Magnetite Nanoparticles)
RN  - EOR26LQQ24 (Ezetimibe)
SB  - IM
MH  - Adsorption
MH  - Ezetimibe/*analysis/chemistry/isolation & purification
MH  - Humans
MH  - Limit of Detection
MH  - Linear Models
MH  - Magnetite Nanoparticles/*chemistry
MH  - Molecular Imprinting/*methods
MH  - Reproducibility of Results
EDAT- 2018/10/13 06:00
MHDA- 2019/02/12 06:00
CRDT- 2018/10/13 06:00
PHST- 2018/06/02 00:00 [received]
PHST- 2018/09/20 00:00 [revised]
PHST- 2018/10/01 00:00 [accepted]
PHST- 2018/10/13 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/10/13 06:00 [entrez]
AID - 10.1002/bmc.4404 [doi]
PST - ppublish
SO  - Biomed Chromatogr. 2019 Jan;33(1):e4404. doi: 10.1002/bmc.4404. Epub 2018 Dec 3.