PMID- 30315323
OWN - NLM
STAT- MEDLINE
DCOM- 20190516
LR  - 20200225
IS  - 1432-0991 (Electronic)
IS  - 0343-8651 (Linking)
VI  - 76
IP  - 1
DP  - 2019 Jan
TI  - cAMP Receptor Protein of Salmonella enterica Serovar Typhimurium Modulate 
      Glycolysis in Macrophages to Induce Cell Apoptosis.
PG  - 1-6
LID - 10.1007/s00284-018-1574-1 [doi]
AB  - We studied the role of glycolysis in the mechanism of cAMP receptor 
      protein-induced macrophage cell death of Salmonella enterica serovar Typhimurium 
      (S. Typhimurium). Cell apoptosis, caspase-3, -8, -9 enzyme activity, and pyruvic 
      acid, lactic acid, ATP, and hexokinase (HK) contents were determined after 
      infection of macrophages with S. Typhimurium SL1344 wild-type and a cAMP receptor 
      protein mutant strain. While cell apoptosis, caspase-3, -8, -9 enzyme activity, 
      lactic acid, hexokinase, and ATP levels significantly changed by infection with 
      crp mutants compared to the wild-type strain (P < 0.05). Our data suggest that 
      the cAMP receptor protein of S. Typhimurium can modulate macrophage death by 
      effecting glycolysis levels. This finding may help to elucidate the mechanisms of 
      S. Typhimurium pathogenesis.
FAU - Ding, Ke
AU  - Ding K
AD  - The Key Lab of Animal Disease and Public Healthy, Henan University of Science and 
      Technology, Luoyang, China.
AD  - Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention 
      and Control, Luoyang, China.
FAU - Zhang, Chunjie
AU  - Zhang C
AD  - The Key Lab of Animal Disease and Public Healthy, Henan University of Science and 
      Technology, Luoyang, China. cjzhang@sina.com.
AD  - Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention 
      and Control, Luoyang, China. cjzhang@sina.com.
FAU - Li, Jing
AU  - Li J
AD  - The Key Lab of Animal Disease and Public Healthy, Henan University of Science and 
      Technology, Luoyang, China.
AD  - Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention 
      and Control, Luoyang, China.
FAU - Chen, Songbiao
AU  - Chen S
AD  - The Key Lab of Animal Disease and Public Healthy, Henan University of Science and 
      Technology, Luoyang, China.
AD  - Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention 
      and Control, Luoyang, China.
FAU - Liao, Chengshui
AU  - Liao C
AD  - The Key Lab of Animal Disease and Public Healthy, Henan University of Science and 
      Technology, Luoyang, China.
AD  - Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention 
      and Control, Luoyang, China.
FAU - Cheng, Xiangchao
AU  - Cheng X
AD  - The Key Lab of Animal Disease and Public Healthy, Henan University of Science and 
      Technology, Luoyang, China.
AD  - Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention 
      and Control, Luoyang, China.
FAU - Yu, Chuang
AU  - Yu C
AD  - The Key Lab of Animal Disease and Public Healthy, Henan University of Science and 
      Technology, Luoyang, China.
AD  - Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention 
      and Control, Luoyang, China.
FAU - Yu, Zuhua
AU  - Yu Z
AD  - The Key Lab of Animal Disease and Public Healthy, Henan University of Science and 
      Technology, Luoyang, China.
AD  - Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention 
      and Control, Luoyang, China.
FAU - Jia, Yanyan
AU  - Jia Y
AD  - The Key Lab of Animal Disease and Public Healthy, Henan University of Science and 
      Technology, Luoyang, China.
AD  - Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention 
      and Control, Luoyang, China.
LA  - eng
PT  - Journal Article
DEP - 20181012
PL  - United States
TA  - Curr Microbiol
JT  - Current microbiology
JID - 7808448
RN  - 0 (Cyclic AMP Receptor Protein)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 8558G7RUTR (Pyruvic Acid)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 3.4.22.- (Caspase 3)
RN  - EC 3.4.22.- (Caspase 8)
RN  - EC 3.4.22.- (Caspase 9)
SB  - IM
MH  - Adenosine Triphosphate/analysis
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Caspase 3/metabolism
MH  - Caspase 8/metabolism
MH  - Caspase 9/metabolism
MH  - Cell Line
MH  - Cyclic AMP Receptor Protein/*genetics/*metabolism
MH  - Glycolysis/*physiology
MH  - Hexokinase/analysis
MH  - Lactic Acid/analysis
MH  - Macrophages/*metabolism
MH  - Mice
MH  - Pyruvic Acid/analysis
MH  - RAW 264.7 Cells
MH  - Salmonella typhimurium/genetics/*metabolism/pathogenicity
EDAT- 2018/10/14 06:00
MHDA- 2019/05/17 06:00
CRDT- 2018/10/14 06:00
PHST- 2018/08/14 00:00 [received]
PHST- 2018/09/18 00:00 [accepted]
PHST- 2018/10/14 06:00 [pubmed]
PHST- 2019/05/17 06:00 [medline]
PHST- 2018/10/14 06:00 [entrez]
AID - 10.1007/s00284-018-1574-1 [pii]
AID - 10.1007/s00284-018-1574-1 [doi]
PST - ppublish
SO  - Curr Microbiol. 2019 Jan;76(1):1-6. doi: 10.1007/s00284-018-1574-1. Epub 2018 Oct 
      12.