PMID- 30315692
OWN - NLM
STAT- MEDLINE
DCOM- 20190403
LR  - 20190403
IS  - 1751-553X (Electronic)
IS  - 1751-5521 (Linking)
VI  - 41
IP  - 2
DP  - 2019 Apr
TI  - The CD9(+) CD11b(-) HLA-DR(-) immunophenotype can be used to diagnose acute 
      promyelocytic leukemia.
PG  - 168-175
LID - 10.1111/ijlh.12929 [doi]
AB  - OBJECTIVE: To investigate the immunophenotypic characteristics of acute 
      promyelocytic leukemia (APL) and explore the sensitivity and specificity of 
      various antibody combinations for the timely and accurate diagnosis APL. METHODS: 
      A retrospective analysis was performed using morphological, immunological, 
      genetic, and molecular biological data from 92 patients diagnosed with APL and 
      190 controls diagnosed with non-APL acute myeloid leukemia. RESULTS: For APL 
      diagnosis, the CD9/CD11b/human leukocyte antigen (HLA)-DR antibody combination 
      had 85% sensitivity and 95% specificity, AUC = 0.85. However, the sensitivity and 
      specificity were 39% and 92%, AUC = 0.65, respectively, for the HLA-DR/CD34/CD117 
      combination, and 80% and 80%, AUC = 0.80, respectively for the CD11b/HLA-DR 
      combination. Significant differences were observed between the different antibody 
      combinations. CONCLUSIONS: The CD9/CD11b/HLA-DR antibody combination displays 
      high sensitivity and specificity and can be used to diagnose APL.
CI  - (c) 2018 John Wiley & Sons Ltd.
FAU - Ren, Fanggang
AU  - Ren F
AUID- ORCID: 0000-0002-8204-698X
AD  - The Haematology Department, The Second Hospital of Shanxi Medical University, 
      Taiyuan City, Shanxi Province, China.
FAU - Zhang, Na
AU  - Zhang N
AD  - The Clinical Laboratory, The Second Hospital of Shanxi Medical University, 
      Taiyuan City, Shanxi Province, China.
FAU - Xu, Zhifang
AU  - Xu Z
AUID- ORCID: 0000-0003-0365-0976
AD  - The Haematology Department, The Second Hospital of Shanxi Medical University, 
      Taiyuan City, Shanxi Province, China.
FAU - Xu, Jing
AU  - Xu J
AD  - The Haematology Department, The Second Hospital of Shanxi Medical University, 
      Taiyuan City, Shanxi Province, China.
FAU - Zhang, Yaofang
AU  - Zhang Y
AD  - The Haematology Department, The Second Hospital of Shanxi Medical University, 
      Taiyuan City, Shanxi Province, China.
FAU - Chen, Xiuhua
AU  - Chen X
AD  - The Haematology Department, The Second Hospital of Shanxi Medical University, 
      Taiyuan City, Shanxi Province, China.
FAU - Tan, Yanhong
AU  - Tan Y
AD  - The Haematology Department, The Second Hospital of Shanxi Medical University, 
      Taiyuan City, Shanxi Province, China.
FAU - Chang, Jianmei
AU  - Chang J
AD  - The Haematology Department, The Second Hospital of Shanxi Medical University, 
      Taiyuan City, Shanxi Province, China.
FAU - Wang, Hongwei
AU  - Wang H
AUID- ORCID: 0000-0002-2902-591X
AD  - The Haematology Department, The Second Hospital of Shanxi Medical University, 
      Taiyuan City, Shanxi Province, China.
LA  - eng
GR  - 81241014/National Natural Science Fund/
GR  - 201602-5/The Younger Fund of the Second Hospital of Shanxi Medical University/
PT  - Clinical Trial
PT  - Journal Article
DEP - 20181013
PL  - England
TA  - Int J Lab Hematol
JT  - International journal of laboratory hematology
JID - 101300213
RN  - 0 (Antigens, CD19)
RN  - 0 (CD11b Antigen)
RN  - 0 (CD19 molecule, human)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (ITGAM protein, human)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD19/*blood
MH  - CD11b Antigen/*blood
MH  - Female
MH  - HLA-DR Antigens/*blood
MH  - Humans
MH  - *Immunophenotyping
MH  - *Leukemia, Promyelocytic, Acute/blood/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*blood
OTO - NOTNLM
OT  - acute promyelocytic leukemia,
OT  - flow cytometry
OT  - immunophenotype
EDAT- 2018/10/14 06:00
MHDA- 2019/04/04 06:00
CRDT- 2018/10/14 06:00
PHST- 2018/06/14 00:00 [received]
PHST- 2018/08/11 00:00 [revised]
PHST- 2018/08/16 00:00 [accepted]
PHST- 2018/10/14 06:00 [pubmed]
PHST- 2019/04/04 06:00 [medline]
PHST- 2018/10/14 06:00 [entrez]
AID - 10.1111/ijlh.12929 [doi]
PST - ppublish
SO  - Int J Lab Hematol. 2019 Apr;41(2):168-175. doi: 10.1111/ijlh.12929. Epub 2018 Oct 
      13.