PMID- 30316729
OWN - NLM
STAT- MEDLINE
DCOM- 20200504
LR  - 20200505
IS  - 1873-5126 (Electronic)
IS  - 1353-8020 (Linking)
VI  - 60
DP  - 2019 Mar
TI  - Is hyperhomocysteinemia associated with the structural changes of the substantia 
      nigra in Parkinson's disease? A two-year follow-up study.
PG  - 46-50
LID - S1353-8020(18)30436-X [pii]
LID - 10.1016/j.parkreldis.2018.10.008 [doi]
AB  - OBJECTIVE: It was recently found that structural changes in the substantia nigra 
      (SN) and motor symptoms become more prominent in Parkinson's disease (PD) 
      patients with striatal silent lacunar infarction (SSLI) than in those without 
      SSLI. Hyperhomocysteinemia (HHCY) was an independent risk factor for SSLI in PD 
      patients. In this follow-up study, we investigated the relationship between HHCY 
      and structural changes of the SN in PD patients. METHODS: A total of 72 untreated 
      early PD patients without SSLI, divided into control and HHCY groups, were 
      enrolled in this study. All participants underwent conventional MRI and diffusion 
      kurtosis imaging (DKI) twice; at baseline and at the 2-year visit. The 
      differences of the following variables between the two groups were analyzed: mean 
      kurtosis (MK) values of the SN, the severity of disease, daily dosage of 
      levodopa, and the variation of these indexes from baseline to 2-year visit. 
      Logistic regression analysis was used to identify the relationship between HHCY 
      and structural changes of the SN in PD patients. RESULTS: 1.All variables 
      mentioned above showed significant differences between the two groups. 2. The 
      variation in MK values of the SN were positively correlated with the variation in 
      the severity of disease. 3. HHCY was an independent risk factor for the variation 
      in MK values of the SN in PD patients. CONCLUSION: HHCY is associated with the 
      structural changes of the SN in PD patients. As PD progresses, motor symptoms 
      become aggravated with increased structural changes to the SN, especially in 
      patients with HHCY.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Zhang, Guohua
AU  - Zhang G
AD  - Department of Neurology, The First People's Hospital of Foshan, Foshan, 528000, 
      Guangdong, People's Republic of China.
FAU - Zhang, Chengguo
AU  - Zhang C
AD  - Department of Neurology, The First People's Hospital of Foshan, Foshan, 528000, 
      Guangdong, People's Republic of China.
FAU - Wang, Yukai
AU  - Wang Y
AD  - Department of Neurology, The First People's Hospital of Foshan, Foshan, 528000, 
      Guangdong, People's Republic of China. Electronic address: wykai2012@qq.com.
FAU - Wang, Lijuan
AU  - Wang L
AD  - Department of Neurology, Guangdong Neuroscience Institute, Guangdong General 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, 
      People's Republic of China.
FAU - Zhang, Yuhu
AU  - Zhang Y
AD  - Department of Neurology, Guangdong Neuroscience Institute, Guangdong General 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, 
      People's Republic of China.
FAU - Xie, Haiqun
AU  - Xie H
AD  - Department of Neurology, The First People's Hospital of Foshan, Foshan, 528000, 
      Guangdong, People's Republic of China.
FAU - Lu, Jiancong
AU  - Lu J
AD  - Department of Neurology, The First People's Hospital of Foshan, Foshan, 528000, 
      Guangdong, People's Republic of China.
FAU - Nie, Kun
AU  - Nie K
AD  - Department of Neurology, Guangdong Neuroscience Institute, Guangdong General 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181005
PL  - England
TA  - Parkinsonism Relat Disord
JT  - Parkinsonism & related disorders
JID - 9513583
SB  - IM
MH  - Aged
MH  - *Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Hyperhomocysteinemia/blood/complications
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - *Parkinson Disease/blood/pathology/physiopathology
MH  - Severity of Illness Index
MH  - *Stroke, Lacunar/blood/etiology/pathology
MH  - Substantia Nigra/diagnostic imaging/*pathology
OTO - NOTNLM
OT  - Diffusion kurtosis imaging
OT  - Hyperhomocysteinemia
OT  - Motor symptoms
OT  - Parkinson's disease
OT  - Substantia nigra
EDAT- 2018/10/15 06:00
MHDA- 2020/05/06 06:00
CRDT- 2018/10/15 06:00
PHST- 2018/02/17 00:00 [received]
PHST- 2018/10/01 00:00 [revised]
PHST- 2018/10/04 00:00 [accepted]
PHST- 2018/10/15 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2018/10/15 06:00 [entrez]
AID - S1353-8020(18)30436-X [pii]
AID - 10.1016/j.parkreldis.2018.10.008 [doi]
PST - ppublish
SO  - Parkinsonism Relat Disord. 2019 Mar;60:46-50. doi: 
      10.1016/j.parkreldis.2018.10.008. Epub 2018 Oct 5.