PMID- 30316983
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 690
DP  - 2019 Jan 18
TI  - Neuronal excitability and spontaneous synaptic transmission in the entorhinal 
      cortex of BDNF heterozygous mice.
PG  - 69-75
LID - S0304-3940(18)30695-5 [pii]
LID - 10.1016/j.neulet.2018.10.019 [doi]
AB  - Brain Derived Neurotropic Factor (BDNF) is a neutrophic factor that is required 
      for the normal neuronal development and function. BDNF is involved in regulation 
      of synapses as well as neuronal excitability. Entorhinal Cortex (EC) is a key 
      brain area involved in many physiological and pathological processes. In this 
      study we investigated the effects of chronically reduced BDNF levels on layer 3 
      pyramidal neurons of EC. We aimed to assess the effects of reduced levels of BDNF 
      on firing properties, spontaneous synaptic currents and excitation/inhibition 
      balance from acute brain slices. Patch clamp recordings were obtained from 
      pyramidal neurons of Entorhinal Cortex Layer 3. Findings of BDNF heterozygous 
      (BDNF (+/-)) mice compared to their wild-type littermates at the age of 23-28 
      days. Action potential threshold was shifted (p = 0,002) to depolarized 
      potentials and spike frequency was smaller in response to somatic current 
      injection steps in BDNF (+/-) mice. Spontaneous synaptic currents were also 
      affected. sEPSC amplitude (p = 0,009), sIPSC frequency (p = 0,001) and sIPSC 
      amplitudes (p = 0,023) were reduced in BDNF (+/-). Decay times of sIPSCs were 
      longer in BDNF (+/-) (p = 0,014). Calculated balance of excitatory/inhibitory 
      balance was shifted in the favor of excitation in BDNF (+/-) mice (p = 0,01). 
      These findings suggest that reductions in concentrations of BDNF results in 
      altered status of excitability and excitation/inhibition imbalance. However, 
      these differences observed in BDNF (+/-) seem to have opposing effects on 
      neuronal activity.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Abidin, Ismail
AU  - Abidin I
AD  - Department of Biophysics, Faculty of Medicine, Karadeniz Technical University, 
      Trabzon, Turkey. Electronic address: ismailabidin@yahoo.com.
FAU - Aydin-Abidin, Selcen
AU  - Aydin-Abidin S
AD  - Department of Biophysics, Faculty of Medicine, Karadeniz Technical University, 
      Trabzon, Turkey.
FAU - Mittmann, Thomas
AU  - Mittmann T
AD  - Institute of Physiology and Pathophysiology, UMC of the Johannes-Gutenberg 
      University, Mainz, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181011
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics/*physiology
MH  - Entorhinal Cortex/*physiology
MH  - Excitatory Postsynaptic Potentials/physiology
MH  - Female
MH  - Gene Knockdown Techniques
MH  - *Heterozygote
MH  - Inhibitory Postsynaptic Potentials/physiology
MH  - Male
MH  - Mice
MH  - Synaptic Transmission/*physiology
OTO - NOTNLM
OT  - BDNF
OT  - BDNF heterozygous mice
OT  - Entorhinal Cortex
OT  - Firing properties
OT  - Synaptic transmission
EDAT- 2018/10/15 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/10/15 06:00
PHST- 2018/07/12 00:00 [received]
PHST- 2018/09/21 00:00 [revised]
PHST- 2018/10/10 00:00 [accepted]
PHST- 2018/10/15 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/10/15 06:00 [entrez]
AID - S0304-3940(18)30695-5 [pii]
AID - 10.1016/j.neulet.2018.10.019 [doi]
PST - ppublish
SO  - Neurosci Lett. 2019 Jan 18;690:69-75. doi: 10.1016/j.neulet.2018.10.019. Epub 
      2018 Oct 11.