PMID- 30317571
OWN - NLM
STAT- MEDLINE
DCOM- 20200318
LR  - 20210311
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 234
IP  - 4
DP  - 2019 Apr
TI  - MicroRNA-133b suppresses bladder cancer malignancy by targeting TAGLN2-mediated 
      cell cycle.
PG  - 4910-4923
LID - 10.1002/jcp.27288 [doi]
AB  - MicroRNAs (miRNAs), a group of small noncoding RNAs, are widely involved in the 
      regulation of gene expression via binding to complementary sequences at 
      3'-untranslated regions (3'-UTRs) of target messenger RNAs. Recently, 
      downregulation of miR-133b has been detected in various human malignancies. Here, 
      the potential biological role of miR-133b in bladder cancer (BC) was 
      investigated. In this study, we found the expression of miR-133b was markedly 
      downregulated in BC tissues and cell lines (5637 and T24), and was correlated 
      with poor overall survival. Notably, transgelin 2 (TAGLN2) was found to be widely 
      upregulated in BC, and overexpression of TAGLN2 also significantly increased 
      risks of advanced TMN stage. We further identified that upregulation of miR-133b 
      inhibited glucose uptake, invasion, angiogenesis, colony formation and enhances 
      gemcitabine chemosensitivity in BC cell lines by targeting TAGLN2. Additionally, 
      we showed that miR-133b promoted the proliferation of BC cells, at least 
      partially through a TAGLN2-mediated cell cycle pathway. Our results suggest a 
      novel miR-133b/TAGLN2/cell cycle pathway axis controlling BC progression; a 
      molecular mechanism which may offer a potential therapeutic target.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Zhao, Feng
AU  - Zhao F
AUID- ORCID: 0000-0001-7111-4812
AD  - Department of Urology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Zhou, Liu-Hua
AU  - Zhou LH
AD  - Department of Urology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Ge, Yu-Zheng
AU  - Ge YZ
AD  - Department of Urology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Ping, Wen-Wen
AU  - Ping WW
AD  - Department of Rheumatology and Immunology, The First Affiliated Hospital of 
      Nanjing Medical University, Nanjing, China.
FAU - Wu, Xin
AU  - Wu X
AD  - Department of Urology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Xu, Zhong-Le
AU  - Xu ZL
AD  - Department of Urology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Wang, Min
AU  - Wang M
AD  - Department of Urology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Sha, Zuo-Liang
AU  - Sha ZL
AD  - Department of Pathology, Pizhou People's Hospital, Xuzhou, China.
FAU - Jia, Rui-Peng
AU  - Jia RP
AD  - Department of Urology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181014
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (MIRN133 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Muscle Proteins)
RN  - 0 (Tagln2 protein, human)
SB  - IM
MH  - Animals
MH  - Cell Cycle Checkpoints/*genetics
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Female
MH  - Humans
MH  - Mice
MH  - Mice, Nude
MH  - MicroRNAs/biosynthesis/*genetics
MH  - Microfilament Proteins/*metabolism
MH  - Muscle Proteins/*metabolism
MH  - Neoplasm Invasiveness/genetics
MH  - Neoplasm Transplantation
MH  - Neovascularization, Pathologic/*genetics
MH  - Transplantation, Heterologous
MH  - Urinary Bladder Neoplasms/*genetics/*prevention & control
OTO - NOTNLM
OT  - TAGLN2
OT  - bladder cancer
OT  - cell cycle
OT  - miR-133b
OT  - tumor suppressor
EDAT- 2018/10/15 06:00
MHDA- 2020/03/19 06:00
CRDT- 2018/10/15 06:00
PHST- 2018/01/18 00:00 [received]
PHST- 2018/07/30 00:00 [accepted]
PHST- 2018/10/15 06:00 [pubmed]
PHST- 2020/03/19 06:00 [medline]
PHST- 2018/10/15 06:00 [entrez]
AID - 10.1002/jcp.27288 [doi]
PST - ppublish
SO  - J Cell Physiol. 2019 Apr;234(4):4910-4923. doi: 10.1002/jcp.27288. Epub 2018 Oct 
      14.