PMID- 30317878
OWN - NLM
STAT- MEDLINE
DCOM- 20200323
LR  - 20211204
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 126
IP  - 1
DP  - 2020 Feb
TI  - Exercise intervention attenuates neuropathic pain in diabetes via mechanisms of 
      mammalian target of rapamycin (mTOR).
PG  - 41-48
LID - 10.1080/13813455.2018.1489851 [doi]
AB  - This study was to examine the role of exercise intervention in modulating 
      neuropathic pain induced by diabetes. Diabetes was induced by streptozotocin 
      (STZ, i.p.) in rats and mechanical hyperalgesia was observed three weeks after 
      STZ. Mechanical withdrawal thresholds were increased after four to five weeks of 
      exercise in STZ rats. We also examined the role of signal of mammalian target of 
      rapamycin (mTOR) in regulating neuropathic pain. Inhibition of neuropathic pain 
      by exercise in STZ rats was accompanied with decreases of p-mTOR, p-S6K1, and 
      p-4E-BP1 in sensory nerves. Blocking mTOR also elevated mechanical withdrawal 
      thresholds in STZ rats. Furthermore, pro-inflammatory IL-6 was greater in sensory 
      nerves of STZ rats. Inhibition of IL-6 decreased mTOR and increased mechanical 
      withdrawal thresholds in STZ rats. Overall, our data suggest the role played by 
      exercise in improving neuropathic pain after STZ and that IL-6-mTOR signal is a 
      part of mechanisms engaged in the effects of exercise.
FAU - Ma, Xiaohui
AU  - Ma X
AD  - Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China.
FAU - Liu, Sitong
AU  - Liu S
AD  - Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China.
FAU - Liu, Dongxue
AU  - Liu D
AD  - Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China.
FAU - Li, Hongwei
AU  - Li H
AD  - Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China.
FAU - Zhao, Zhen
AU  - Zhao Z
AD  - Department of Blood Transfusion, The First Hospital of Jilin University, 
      Changchun, Jilin, China.
LA  - eng
PT  - Journal Article
DEP - 20181013
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (Eif4ebp1 protein, rat)
RN  - 0 (Il6 protein, rat)
RN  - 0 (Interleukin-6)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 5W494URQ81 (Streptozocin)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases)
RN  - EC 2.7.11.1 (Rps6kb1 protein, rat)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Experimental/chemically 
      induced/complications/*genetics/pathology
MH  - Gene Expression Regulation
MH  - Hyperalgesia/etiology/genetics/pathology/*therapy
MH  - Interleukin-6/genetics/metabolism
MH  - Intracellular Signaling Peptides and Proteins/genetics/metabolism
MH  - Male
MH  - Pain Threshold/physiology
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ribosomal Protein S6 Kinases/genetics/metabolism
MH  - Signal Transduction
MH  - Streptozocin
MH  - TOR Serine-Threonine Kinases/*genetics/metabolism
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Exercise
OT  - diabetes
OT  - neuropathic pain
OT  - peripheral nerve
OT  - rapamycin
EDAT- 2018/10/16 06:00
MHDA- 2020/03/24 06:00
CRDT- 2018/10/16 06:00
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2020/03/24 06:00 [medline]
PHST- 2018/10/16 06:00 [entrez]
AID - 10.1080/13813455.2018.1489851 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2020 Feb;126(1):41-48. doi: 10.1080/13813455.2018.1489851. 
      Epub 2018 Oct 13.