PMID- 30317879
OWN - NLM
STAT- MEDLINE
DCOM- 20200831
LR  - 20200831
IS  - 2047-4881 (Electronic)
IS  - 2047-4873 (Linking)
VI  - 26
IP  - 7
DP  - 2019 May
TI  - Exercise training to reduce cardiovascular risk in patients with metabolic 
      syndrome and type 2 diabetes mellitus: How does it work?
PG  - 701-708
LID - 10.1177/2047487318805158 [doi]
AB  - Metabolic syndrome (MetS) - a clustering of pathological conditions, including 
      abdominal obesity, hypertension, dyslipidemia and hyperglycaemia - is closely 
      associated with the development of type 2 diabetes mellitus (T2DM) and a high 
      risk of cardiovascular disease. A combination of multigenetic predisposition and 
      lifestyle choices accounts for the varying inter-individual risk to develop MetS 
      and T2DM, as well as for the individual amount of the increase in cardiovascular 
      risk in those patients. A physically active lifestyle can offset about half of 
      the genetically mediated cardiovascular risk. Yet, the extent to which 
      standardized exercise programmes can reduce cardiovascular risk differs between 
      patients. Exercise parameters, such as frequency, intensity, type and duration or 
      number of repetitions, differentially target metabolic function, vascular health 
      and physical fitness. In addition, exercise-induced molecular mechanisms are 
      modulated by other patient-specific variables, such as age, diet and medication. 
      This review discusses the molecular and cellular mechanisms underlying the 
      effects of exercise training on cardiovascular risk specifically in patients with 
      MetS and T2DM.
FAU - Krankel, Nicolle
AU  - Krankel N
AD  - 1 Charite - Universitatsmedizin Berlin, Klinik fur Kardiologie, Campus Benjamin 
      Steglitz, Berlin, Germany.
AD  - 2 DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, 
      Germany.
FAU - Bahls, Martin
AU  - Bahls M
AD  - 3 University Medicine Greifswald, Department of Internal Medicine B, Greifswald, 
      Germany.
AD  - 4 DZHK (German Centre for Cardiovascular Research), Partner Site, Greifswald, 
      Germany.
FAU - Van Craenenbroeck, Emeline M
AU  - Van Craenenbroeck EM
AD  - 5 Department of Cardiology, Antwerp University Hospital, Antwerp, Belgium.
FAU - Adams, Volker
AU  - Adams V
AD  - 6 Department of Molecular and Experimental Cardiology, TU Dresden, Heart Centre 
      Dresden, Dresden, Germany.
FAU - Serratosa, Luis
AU  - Serratosa L
AD  - 7 Hospital Universitario Quironsalud, Madrid, Spain.
AD  - 8 Ripoll & De Prado Sport Clinic, FIFA Medical Centre of Excellence, Madrid, 
      Spain.
FAU - Solberg, Erik Ekker
AU  - Solberg EE
AD  - 9 Diakonhjemmet hospital, Department of Medicine, Oslo, Norway.
FAU - Hansen, Dominique
AU  - Hansen D
AD  - 10 Hasselt University, Faculty of Rehabilitation Sciences, Diepenbeek, Belgium.
AD  - 11 Heart Centre Hasselt, Jessa Hospital, Hasselt, Belgium.
FAU - Dorr, Marcus
AU  - Dorr M
AD  - 3 University Medicine Greifswald, Department of Internal Medicine B, Greifswald, 
      Germany.
AD  - 4 DZHK (German Centre for Cardiovascular Research), Partner Site, Greifswald, 
      Germany.
FAU - Kemps, Hareld
AU  - Kemps H
AD  - 12 Department of Cardiology, Maxima Medical Centre, Veldhoven, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20181015
PL  - England
TA  - Eur J Prev Cardiol
JT  - European journal of preventive cardiology
JID - 101564430
SB  - IM
MH  - Cardiovascular Diseases/diagnosis/epidemiology/*prevention & control
MH  - Diabetes Mellitus, Type 2/diagnosis/epidemiology/*therapy
MH  - *Exercise Therapy
MH  - *Healthy Lifestyle
MH  - Humans
MH  - Metabolic Syndrome/diagnosis/epidemiology/*therapy
MH  - *Preventive Health Services
MH  - Protective Factors
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Risk Reduction Behavior
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Exercise training
OT  - diabetes
OT  - glycaemic control
OT  - inflammation
OT  - signalling
EDAT- 2018/10/16 06:00
MHDA- 2020/09/01 06:00
CRDT- 2018/10/16 06:00
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2020/09/01 06:00 [medline]
PHST- 2018/10/16 06:00 [entrez]
AID - 10.1177/2047487318805158 [doi]
PST - ppublish
SO  - Eur J Prev Cardiol. 2019 May;26(7):701-708. doi: 10.1177/2047487318805158. Epub 
      2018 Oct 15.