PMID- 30318177
OWN - NLM
STAT- MEDLINE
DCOM- 20181231
LR  - 20181231
IS  - 1473-0502 (Print)
IS  - 1473-0502 (Linking)
VI  - 57
IP  - 6
DP  - 2018 Dec
TI  - Implication of antibodies against human leukocyte antigen in simultaneous 
      presentation of fetal and neonatal alloimmune thrombocytopenia and neutropenia.
PG  - 773-776
LID - S1473-0502(18)30251-9 [pii]
LID - 10.1016/j.transci.2018.09.018 [doi]
AB  - Fetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal alloimmune 
      neutropenia (NAN) are two rare complications of newborns caused by antibodies 
      against paternal inherited antigens. Human platelet (HPA) and neutrophil antigens 
      (HNA) are the common targets. Human leukocyte antigen (HLA) class I proteins are 
      also expressed on platelets and neutrophils and anti-HLA antibodies have 
      occasionally been implicated in these complications. We report a premature twin 
      infant who presented with severe thrombocytopenia and neutropenia clinically 
      compatible with FNAIT and NAN, from a mother with no identifiable HPA or HNA 
      antibodies, but with very high levels of complement-fixing antibodies against 
      paternal inherited HLA. These antibodies were also detected in the infant. HLA 
      antibodies are commonly present in multiparous women who deliver healthy infants. 
      They can, however, be cytotoxic and cause clinical complications after blood 
      products transfusion (TRALI and becoming refractory to platelets transfusion) and 
      after organ transplantation (allogeneic organ rejection).
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Gimferrer, Idoia
AU  - Gimferrer I
AD  - Bloodworks NW, Seattle, WA, United States. Electronic address: 
      igimferrer@bloodworksNW.org.
FAU - Teramura, Gayle
AU  - Teramura G
AD  - Bloodworks NW, Seattle, WA, United States.
FAU - Gallagher, Mary
AU  - Gallagher M
AD  - Bloodworks NW, Seattle, WA, United States.
FAU - Warner, Paul
AU  - Warner P
AD  - Bloodworks NW, Seattle, WA, United States.
FAU - Ji, Hongxiu
AU  - Ji H
AD  - Department of Pathology, Overlake Hospital Medical Center, Bellevue, WA, United 
      States.
FAU - Chabra, Shilpi
AU  - Chabra S
AD  - Division of Neonatology, Department of Pediatrics, University of Washington, 
      Seattle, WA, United States.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180929
PL  - England
TA  - Transfus Apher Sci
JT  - Transfusion and apheresis science : official journal of the World Apheresis 
      Association : official journal of the European Society for Haemapheresis
JID - 101095653
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
MH  - Antibodies/*immunology
MH  - Blood Platelets/immunology
MH  - Female
MH  - Fetus/*pathology
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Neutropenia/*immunology/pathology
MH  - Neutrophils/immunology
MH  - Placenta/pathology
MH  - Pregnancy
MH  - Thrombocytopenia, Neonatal Alloimmune/*immunology/pathology
OTO - NOTNLM
OT  - Fetal and neonatal alloimmune thrombocytopenia
OT  - Human leukocyte antigen
OT  - Human neutrophil antigen
OT  - Human platelet antigen
OT  - Neonatal alloimmune neutropenia
EDAT- 2018/10/16 06:00
MHDA- 2019/01/01 06:00
CRDT- 2018/10/16 06:00
PHST- 2018/06/25 00:00 [received]
PHST- 2018/09/21 00:00 [revised]
PHST- 2018/09/25 00:00 [accepted]
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2019/01/01 06:00 [medline]
PHST- 2018/10/16 06:00 [entrez]
AID - S1473-0502(18)30251-9 [pii]
AID - 10.1016/j.transci.2018.09.018 [doi]
PST - ppublish
SO  - Transfus Apher Sci. 2018 Dec;57(6):773-776. doi: 10.1016/j.transci.2018.09.018. 
      Epub 2018 Sep 29.