PMID- 30318663
OWN - NLM
STAT- MEDLINE
DCOM- 20200511
LR  - 20200511
IS  - 1365-277X (Electronic)
IS  - 0952-3871 (Linking)
VI  - 32
IP  - 1
DP  - 2019 Feb
TI  - Weight improvement with the use of protein and energy enriched nutritional 
      formula in infants with a prolonged PICU stay.
PG  - 3-10
LID - 10.1111/jhn.12603 [doi]
AB  - BACKGROUND: Reaching an optimal nutritional intake is challenging in critically 
      ill infants. One possible way to minimise nutritional deficits is the use of 
      protein and energy-enriched (PE)-formulas. We aimed to describe weight 
      achievement and gastrointestinal symptoms in infants admitted to the paediatric 
      intensive care unit (PICU) while receiving PE-formula for a prolonged period. 
      METHODS: Records from infants admitted to a multidisciplinary PICU and using 
      PE-formula were analysed retrospectively. Infants were eligible if they received 
      PE-formula daily for at least 2 weeks. Weight achievement was determined as the 
      difference between weight-for-age (WFA) Z-scores at the start and end of 
      PE-formula use. Gastrointestinal symptoms, including gastric residual volume, 
      constipation and vomiting, were evaluated as tolerance parameters. RESULTS: 
      Seventy infants with a median [interquartile range (IQR)] age of 76 (30-182) days 
      were eligible. The PICU duration was 50 (35-83) days during which they received 
      PE-formula for 30 (21-54) days. Predominant admission diagnoses were post-cardiac 
      surgery, respiratory and cardiac diagnosis. A significant mean (SD) WFA Z-score 
      increase of 0.48 (1.10) (P < 0.001) and a median (IQR) weight gain of 5.80 
      (3.28-9.04) g kg(-1) day(-1) was observed. Multivariate regression showed that a 
      lower WFA Z-score at start was associated with a higher WFA Z-score increase 
      during PE-formula use (beta -0.35 (95% confidence interval =  -0.50 to -0.19); 
      P < 0.001). The maximum 24-h gastric residual volume was 8.1 mL (IQR = 2.2-14.3) 
      for each 1 kg in bodyweight. Three (4%) infants were treated for diarrhoea and 
      three infants were treated for vomiting. CONCLUSIONS: The majority of infants 
      with a prolonged PICU stay showed weight improvement when using PE-formula. 
      PE-formula was well tolerated because gastrointestinal symptoms only occurred in 
      few infants.
CI  - (c) 2018 The British Dietetic Association Ltd.
FAU - Eveleens, R D
AU  - Eveleens RD
AUID- ORCID: 0000-0003-1793-8057
AD  - Department of Paediatrics and Paediatric Surgery, Intensive Care Unit, Erasmus 
      MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, 
      The Netherlands.
FAU - Dungen, D K
AU  - Dungen DK
AD  - Department of Paediatrics and Paediatric Surgery, Intensive Care Unit, Erasmus 
      MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, 
      The Netherlands.
FAU - Verbruggen, S C A T
AU  - Verbruggen SCAT
AD  - Department of Paediatrics and Paediatric Surgery, Intensive Care Unit, Erasmus 
      MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, 
      The Netherlands.
FAU - Hulst, J M
AU  - Hulst JM
AD  - Division of Paediatric Gastroenterology, Department of Paediatrics, Erasmus 
      MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, 
      The Netherlands.
FAU - Joosten, K F M
AU  - Joosten KFM
AD  - Department of Paediatrics and Paediatric Surgery, Intensive Care Unit, Erasmus 
      MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, 
      The Netherlands.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181014
PL  - England
TA  - J Hum Nutr Diet
JT  - Journal of human nutrition and dietetics : the official journal of the British 
      Dietetic Association
JID - 8904840
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - Critical Illness/therapy
MH  - Dietary Proteins/*administration & dosage
MH  - *Energy Intake
MH  - Female
MH  - *Food, Fortified
MH  - Gastrointestinal Diseases/epidemiology/etiology
MH  - Humans
MH  - Infant
MH  - *Infant Formula
MH  - Infant, Newborn
MH  - Intensive Care Units, Pediatric
MH  - Male
MH  - Nutritional Requirements
MH  - Regression Analysis
MH  - Retrospective Studies
MH  - Time Factors
MH  - *Weight Gain
OTO - NOTNLM
OT  - critical care
OT  - infants
OT  - nutritional intake
OT  - protein energy-enriched formula
OT  - tolerance
OT  - weight gain
EDAT- 2018/10/16 06:00
MHDA- 2020/05/12 06:00
CRDT- 2018/10/16 06:00
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2020/05/12 06:00 [medline]
PHST- 2018/10/16 06:00 [entrez]
AID - 10.1111/jhn.12603 [doi]
PST - ppublish
SO  - J Hum Nutr Diet. 2019 Feb;32(1):3-10. doi: 10.1111/jhn.12603. Epub 2018 Oct 14.