PMID- 30318704
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20211204
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Linking)
VI  - 177
IP  - 7
DP  - 2018 Oct
TI  - Ethnic variation of IL-4 intron 3 VNTR gene polymorphism; its association with 
      type 2 diabetes mellitus and its complication (neuropathy) in Egyptian subjects.
PG  - 635-640
LID - 10.1002/ajmg.b.32647 [doi]
AB  - Type 2 diabetes mellitus (T2DM) has multigenetic and environmental interactive 
      factors. Although diabetic neuropathies (DPN) are the most common, but at the 
      same time, the least recognized and understood long-term complication of 
      diabetes. This study aimed to investigate the association of IL-4 VNTR gene 
      polymorphism with T2DM complicated with neuropathy in Egyptian subjects. This is 
      a case control study including 102 T2DM Egyptian patients, plus 188 unrelated 
      healthy individuals as controls. They were evaluated for variable number tandem 
      repeat (VNTR); 70 base pair repeats located in the intron 3; of IL-4 gene using 
      the PCR technique. Homozygote frequency of the three-repeat allele (A1/A1) 
      genotype of IL-4 VNTR was nearly equal among diabetic cases and controls (60.8% 
      vs. 62.2%, respectively). Heterozygous frequency of (A1/A2) genotype was higher 
      among controls compared to cases (33.5% vs. 19.6%, respectively) but not 
      statistically significant. The (A2) allele had a significantly higher frequency 
      in diabetic cases compared to controls (29.3% vs. 21.0%, respectively) while the 
      (A1) allele had lower frequency but not significant one (70.7% vs. 79.0%, 
      respectively). Comparing cases complicated with diabetic neuropathy vs. 
      noncomplicated cases regarding their polymorphic IL-4 (VNTR) genotypes revealed a 
      nonsignificant lower frequency of (A1A1) genotype (57.1% vs. 65.1%, respectively, 
      p = .57) with a higher combined (A2A2 + A1/A2) genotype frequency (42.9% vs. 
      34.9%, respectively). Only two haplotypes (A1) & (A2) of IL-4 (VNTR) gene were 
      recognized among Egyptian population; (A2) allele may influence in diabetes but 
      not its complication (neuropathy) among Egyptian diabetic patients.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Ali, R
AU  - Ali R
AUID- ORCID: 0000-0003-3703-0548
AD  - Clinical Laboratory Sciences Department, Faculty of Applied Medical Sciences, 
      Taibah University, Al-Madinah Al Monawara, Kingdom of Saudi Arabia.
AD  - Genetics Unit, Children Hospital, Faculty of medicine, Mansoura University, 
      Mansoura, Egypt.
FAU - El-Said, A
AU  - El-Said A
AD  - Genetics Unit, Children Hospital, Faculty of medicine, Mansoura University, 
      Mansoura, Egypt.
FAU - El-Baz, H
AU  - El-Baz H
AD  - Biochemistry Dept., Genetic Engineering and Biotechnology Division, National 
      Research Centre, Cairo, Egypt.
AD  - Clinical Biochemistry Department, Faculty of Medicine, University of Jeddah, 
      Jeddah, Kingdom of Saudi Arabia.
FAU - Settin, A
AU  - Settin A
AD  - Pediatrics and Genetics Department, Faculty of Medicine, Mansoura University, 
      Egypt.
LA  - eng
PT  - Journal Article
DEP - 20181014
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (IL4 protein, human)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics/metabolism
MH  - Diabetic Neuropathies/*genetics/metabolism
MH  - Egypt/epidemiology
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Interleukin-4/*genetics/metabolism
MH  - Introns
MH  - Male
MH  - Middle Aged
MH  - Minisatellite Repeats
MH  - Polymorphism, Genetic
OTO - NOTNLM
OT  - IL-4 (VNTR) neuropathy
OT  - alleles
OT  - diabetes mellitus
OT  - polymorphism
EDAT- 2018/10/16 06:00
MHDA- 2019/11/05 06:00
CRDT- 2018/10/16 06:00
PHST- 2018/02/26 00:00 [received]
PHST- 2018/04/30 00:00 [revised]
PHST- 2018/05/04 00:00 [accepted]
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
PHST- 2018/10/16 06:00 [entrez]
AID - 10.1002/ajmg.b.32647 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2018 Oct;177(7):635-640. doi: 
      10.1002/ajmg.b.32647. Epub 2018 Oct 14.