PMID- 30319395
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 10
DP  - 2018
TI  - Apolipoprotein E epsilon4 Specifically Modulates the Hippocampus Functional 
      Connectivity Network in Patients With Amnestic Mild Cognitive Impairment.
PG  - 289
LID - 10.3389/fnagi.2018.00289 [doi]
LID - 289
AB  - The presence of both apolipoprotein E (APOE) epsilon4 allele and amnestic mild 
      cognitive impairment (aMCI) are considered to be risk factors for Alzheimer's 
      disease (AD). Numerous neuroimaging studies have suggested that the modulation of 
      APOE epsilon4 affects intrinsic functional brain networks, both in healthy populations 
      and in AD patients. However, it remains largely unclear whether and how epsilon4 allele 
      modulates the brain's functional network architecture in subjects with aMCI. 
      Using resting-state functional magnetic resonance imaging (fMRI) and graph-theory 
      approaches-functional connectivity strength (FCS), we investigate the topological 
      organization of the whole-brain functional network in 28 aMCI epsilon4 carriers and 38 
      aMCI epsilon3epsilon3 carriers. In the present study, we first observe that epsilon4-related FCS 
      increases in the right hippocampus/parahippocampal gyrus (HIP/PHG). Subsequent 
      seed-based resting-state functional connectivity (RSFC) analysis revealed that, 
      compared with the epsilon3epsilon3 carriers, the epsilon4 carriers had lower or higher RSFCs 
      between the right HIP/PHG seed and the bilateral medial prefrontal cortex (MPFC) 
      or the occipital cortex, respectively. Further correlation analyses have revealed 
      that the FCS values in the right HIP/PHG and lower HIP/PHG-RSFCs with the 
      bilateral MPFC were significantly correlated with the impairment of episodic 
      memory and executive function in the aMCI epsilon4 carriers. Importantly, the logistic 
      regression analysis showed that the HIP/PHG-RSFC with the bilateral MPFC 
      predicted aMCI-conversion to AD. These findings suggest that the APOE epsilon4 allele 
      may modulate the large-scale brain network in aMCI subjects, facilitating our 
      understanding of how the entire assembly of the brain network reorganizes in 
      response to APOE variants in aMCI. Further longitudinal studies need to be 
      conducted, in order to examine whether these network measures could serve as 
      primary predictors of conversion from aMCI epsilon4 carriers to AD.
FAU - Zhu, Lin
AU  - Zhu L
AD  - Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, 
      Southeast University, Nanjing, China.
FAU - Shu, Hao
AU  - Shu H
AD  - Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, 
      Southeast University, Nanjing, China.
FAU - Liu, Duan
AU  - Liu D
AD  - Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, 
      Southeast University, Nanjing, China.
FAU - Guo, Qihao
AU  - Guo Q
AD  - Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Wang, Zan
AU  - Wang Z
AD  - Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, 
      Southeast University, Nanjing, China.
FAU - Zhang, Zhijun
AU  - Zhang Z
AD  - Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, 
      Southeast University, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20180927
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC6170627
OTO - NOTNLM
OT  - Alzheimer's disease (AD)
OT  - amnestic mild cognitive impairment (aMCI)
OT  - apolipoprotein E (APOE) epsilon4
OT  - functional connectivity
OT  - resting-state fMRI
EDAT- 2018/10/16 06:00
MHDA- 2018/10/16 06:01
PMCR- 2018/01/01
CRDT- 2018/10/16 06:00
PHST- 2018/06/25 00:00 [received]
PHST- 2018/09/03 00:00 [accepted]
PHST- 2018/10/16 06:00 [entrez]
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2018/10/16 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2018.00289 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2018 Sep 27;10:289. doi: 10.3389/fnagi.2018.00289. 
      eCollection 2018.