PMID- 30319404
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 9
DP  - 2018
TI  - Chelerythrine Attenuates the Inflammation of Lipopolysaccharide-Induced Acute 
      Lung Inflammation Through NF-kappaB Signaling Pathway Mediated by Nrf2.
PG  - 1047
LID - 10.3389/fphar.2018.01047 [doi]
LID - 1047
AB  - Chelerythrine (CH), is a kind of benzo[c] phenanthridine alkaloid isolated from 
      plants such as Chelidonium, with pharmacological activities as antitumor, 
      antibiosis and anti-inflammation. However, few studies have demonstrated whether 
      CH could protect against lipopolysaccharide (LPS)-induced acute lung injury 
      (ALI), and the underlying mechanism is also uncertain. The purpose of the present 
      study was to investigate the anti-inflammatory effects of CH on LPS-induced ALI 
      in mice and in RAW264.7 cells. In this study, we demonstrated that treatment with 
      CH significantly ameliorated LPS-induced pathological changes in the lung. CH 
      also attenuated LPS-induced W/D ratio, inflammatory cell infiltration. Meanwhile, 
      LPS-induced Tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and 
      interleukin 1beta (IL-1beta) production and oxidative stress were markedly suppressed 
      by CH. Furthermore, western blot showed that CH suppressed LPS-stimulated 
      inflammation of RAW264.7 cells through activation of nuclear factor kappa-B 
      (NF-kappaB) pathway. Knocking down of nuclear factor erythroid 2-related factor 2 
      (Nrf2) led to the reduction of nuclear translocation of the NF-kappaB p65, which 
      triggered inflammation. These experimental results provided evidence that CH 
      could be a potential therapeutic candidate for the intervention of ALI caused by 
      LPS.
FAU - Fan, Lu
AU  - Fan L
AD  - School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 
      Nanjing, China.
FAU - Fan, Ye
AU  - Fan Y
AD  - Department of Emergency Medicine, Nanjing General Hospital/Jinling Hospital, 
      Medical School of Nanjing University, Nanjing, China.
FAU - Liu, Li
AU  - Liu L
AD  - School of Pharmacy, Guangdong Medical University, Dongguan, China.
FAU - Tao, Weiwei
AU  - Tao W
AD  - Center for Translational Systems Biology and Neuroscience, School of Basic 
      Biomedical Science, Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Shan, Xin
AU  - Shan X
AD  - Center for Translational Systems Biology and Neuroscience, School of Basic 
      Biomedical Science, Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Dong, Yu
AU  - Dong Y
AD  - Center for Translational Systems Biology and Neuroscience, School of Basic 
      Biomedical Science, Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Li, Lin
AU  - Li L
AD  - Center for Translational Systems Biology and Neuroscience, School of Basic 
      Biomedical Science, Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Zhang, Sen
AU  - Zhang S
AD  - Center for Translational Systems Biology and Neuroscience, School of Basic 
      Biomedical Science, Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Wang, Hanqing
AU  - Wang H
AD  - School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 
      Nanjing, China.
AD  - College of Pharmacy, Ningxia Medical University, Yinchuan, China.
LA  - eng
PT  - Journal Article
DEP - 20180926
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC6169195
OTO - NOTNLM
OT  - ALI
OT  - LPS
OT  - NF-kappaB
OT  - Nrf2
OT  - chelerythrine
OT  - inflammation
EDAT- 2018/10/16 06:00
MHDA- 2018/10/16 06:01
PMCR- 2018/09/26
CRDT- 2018/10/16 06:00
PHST- 2018/04/11 00:00 [received]
PHST- 2018/08/30 00:00 [accepted]
PHST- 2018/10/16 06:00 [entrez]
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2018/10/16 06:01 [medline]
PHST- 2018/09/26 00:00 [pmc-release]
AID - 10.3389/fphar.2018.01047 [doi]
PST - epublish
SO  - Front Pharmacol. 2018 Sep 26;9:1047. doi: 10.3389/fphar.2018.01047. eCollection 
      2018.