PMID- 30319436
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 9
DP  - 2018
TI  - Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review 
      of Current Knowledge and the Implications for Health and Metabolic Diseases.
PG  - 1307
LID - 10.3389/fphys.2018.01307 [doi]
LID - 1307
AB  - Physical exercise has beneficial effects on metabolic diseases, and a combined 
      therapeutic regimen of regular exercise and pharmaceutical treatment is often 
      recommended for their clinical management. However, the mechanisms by which 
      exercise produces these beneficial effects are not fully understood. Myokines, a 
      group of skeletal muscle (SkM) derived peptides may play an important part in 
      this process. Myokines are produced, expressed and released by muscle fibers 
      under contraction and exert both local and pleiotropic effects. Myokines such as 
      IL-6, IL-10, and IL-1ra released during physical exercise mediate its health 
      benefits. Just as exercise seems to promote the myokine response, physical 
      inactivity seems to impair it, and could be a mechanism to explain the 
      association between sedentary behavior and many chronic diseases. Myokines help 
      configure the immune-metabolic factor interface and the health promoting effects 
      of physical exercise through the release of humoral factors capable of 
      interacting with other tissues, mainly adipose tissue (AT). AT itself secretes 
      proinflammatory cytokines (adipokines) as a result of physical inactivity and it 
      is well recognized that AT inflammation can lead to the development of metabolic 
      diseases, such as type 2 diabetes mellitus (T2DM) and atherosclerosis. On the 
      other hand, the browning phenotype of AT has been suggested to be one of the 
      mechanisms through which physical exercise improves body composition in 
      overweight/obese individuals. Although, many cytokines are involved in the 
      crosstalk between SkM and AT, in respect of these effects, it is IL-6, IL-15, 
      irisin, and myostatin which seem to have the decisive role in this "conversation" 
      between AT and SkM. This review article proposes to bring together the latest 
      "state of the art" knowledge regarding Myokines and muscle-adipose tissue 
      crosstalk. Furthermore, it is intended to particularly focus on the 
      immune-metabolic changes from AT directly mediated by myokines.
FAU - Leal, Luana G
AU  - Leal LG
AD  - Integrated Group of Biotechnology, Laboratory of Adipose Tissue Biology, 
      University of Mogi das Cruzes, Sao Paulo, Brazil.
AD  - Technological Research Group, University of Mogi das Cruzes, Sao Paulo, Brazil.
FAU - Lopes, Magno A
AU  - Lopes MA
AD  - Integrated Group of Biotechnology, Laboratory of Adipose Tissue Biology, 
      University of Mogi das Cruzes, Sao Paulo, Brazil.
FAU - Batista, Miguel L Jr
AU  - Batista ML Jr
AD  - Integrated Group of Biotechnology, Laboratory of Adipose Tissue Biology, 
      University of Mogi das Cruzes, Sao Paulo, Brazil.
AD  - Technological Research Group, University of Mogi das Cruzes, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180924
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6166321
OTO - NOTNLM
OT  - IL-6
OT  - browning
OT  - exercise-factor
OT  - immunometabolism
OT  - inflammation
OT  - irisin
EDAT- 2018/10/16 06:00
MHDA- 2018/10/16 06:01
PMCR- 2018/09/24
CRDT- 2018/10/16 06:00
PHST- 2018/06/20 00:00 [received]
PHST- 2018/08/29 00:00 [accepted]
PHST- 2018/10/16 06:00 [entrez]
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2018/10/16 06:01 [medline]
PHST- 2018/09/24 00:00 [pmc-release]
AID - 10.3389/fphys.2018.01307 [doi]
PST - epublish
SO  - Front Physiol. 2018 Sep 24;9:1307. doi: 10.3389/fphys.2018.01307. eCollection 
      2018.