PMID- 30319644
OWN - NLM
STAT- MEDLINE
DCOM- 20191009
LR  - 20191010
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 9
DP  - 2018
TI  - Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal 
      Microbiota Transplantation: A Pilot Study.
PG  - 2195
LID - 10.3389/fimmu.2018.02195 [doi]
LID - 2195
AB  - Patients with steroid refractory gastrointestinal (GI) tract graft- vs.-host 
      disease (GvHD) face a poor prognosis and limited therapeutic options. To 
      accurately assess the efficacy and safety of fecal microbiota transplantation 
      (FMT) in treating steroid refractory GI tract GvHD, we conducted a pilot study 
      involving eight patients. Having received FMTs, all patients' clinical symptoms 
      relieved, bacteria enriched, and microbiota composition reconstructed. Compared 
      to those who did not receive FMT, these eight patients achieved a higher 
      progression-free survival. FMT can serve as a therapeutic option for GI tract 
      aGVHD, but its effectiveness and safety need further evaluations. Clinical Trial 
      Registration: NCT03148743.
FAU - Qi, Xiaofei
AU  - Qi X
AD  - Department of Hematology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Li, Xuewei
AU  - Li X
AD  - Department of Hematology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Zhao, Ye
AU  - Zhao Y
AD  - Department of Hematology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Wu, Xiaojin
AU  - Wu X
AD  - Department of Hematology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Chen, Feng
AU  - Chen F
AD  - Department of Hematology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Ma, Xiao
AU  - Ma X
AD  - Department of Hematology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Zhang, Faming
AU  - Zhang F
AD  - Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
FAU - Wu, Depei
AU  - Wu D
AD  - Department of Hematology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
LA  - eng
SI  - ClinicalTrials.gov/NCT03148743
PT  - Journal Article
PT  - Observational Study
DEP - 20180925
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Acute Disease/therapy
MH  - Adult
MH  - Drug Resistance
MH  - *Fecal Microbiota Transplantation
MH  - Feces/microbiology
MH  - Female
MH  - Glucocorticoids/*pharmacology/therapeutic use
MH  - Graft vs Host Disease/immunology/mortality/*therapy
MH  - Hematologic Neoplasms/therapy
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Intestinal Diseases/immunology/mortality/*therapy
MH  - Intestines/immunology/microbiology
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Progression-Free Survival
MH  - Prospective Studies
MH  - Young Adult
PMC - PMC6167440
OTO - NOTNLM
OT  - a pilot study
OT  - diarrhea
OT  - fecal microbiota transplantations
OT  - graft-vs.-host disease
OT  - refractory gastrointestinal
EDAT- 2018/10/16 06:00
MHDA- 2019/10/11 06:00
PMCR- 2018/01/01
CRDT- 2018/10/16 06:00
PHST- 2018/04/10 00:00 [received]
PHST- 2018/09/05 00:00 [accepted]
PHST- 2018/10/16 06:00 [entrez]
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2019/10/11 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2018.02195 [doi]
PST - epublish
SO  - Front Immunol. 2018 Sep 25;9:2195. doi: 10.3389/fimmu.2018.02195. eCollection 
      2018.