PMID- 30319969
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 8
DP  - 2018
TI  - Interactions Between Nanoparticles and Dendritic Cells: From the Perspective of 
      Cancer Immunotherapy.
PG  - 404
LID - 10.3389/fonc.2018.00404 [doi]
LID - 404
AB  - Dendritic cells (DCs) are the primary antigen-presenting cells and play key roles 
      in the orchestration of the innate and adaptive immune system. Targeting DCs by 
      nanotechnology stands as a promising strategy for cancer immunotherapy. The 
      physicochemical properties of nanoparticles (NPs) influence their interactions 
      with DCs, thus altering the immune outcome of DCs by changing their functions in 
      the processes of maturation, homing, antigen processing and antigen presentation. 
      In this review, we summarize the recent progress in targeting DCs using NPs as a 
      drug delivery carrier in cancer immunotherapy, the recognition of NPs by DCs, and 
      the ways the physicochemical properties of NPs affect DCs' functions. Finally, 
      the molecular pathways in DCs that are affected by NPs are also discussed.
FAU - Jia, Jianbo
AU  - Jia J
AD  - Key Laboratory for Water Quality and Conservation of the Pearl River Delta, 
      Ministry of Education, Institute of Environmental Research at Greater Bay, 
      Guangzhou University, Guangzhou, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
FAU - Xin, Yan
AU  - Xin Y
AD  - School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
FAU - Jiang, Cuijuan
AU  - Jiang C
AD  - School of Environmental Science and Engineering, Shandong University, Jinan, 
      China.
FAU - Yan, Bing
AU  - Yan B
AD  - Key Laboratory for Water Quality and Conservation of the Pearl River Delta, 
      Ministry of Education, Institute of Environmental Research at Greater Bay, 
      Guangzhou University, Guangzhou, China.
AD  - School of Environmental Science and Engineering, Shandong University, Jinan, 
      China.
FAU - Zhai, Shumei
AU  - Zhai S
AD  - School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180925
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC6167641
OTO - NOTNLM
OT  - DC functions
OT  - DC targeting
OT  - cancer immunotherapy
OT  - nanoparticles
OT  - physicochemical properties
EDAT- 2018/10/16 06:00
MHDA- 2018/10/16 06:01
PMCR- 2018/01/01
CRDT- 2018/10/16 06:00
PHST- 2018/06/28 00:00 [received]
PHST- 2018/09/04 00:00 [accepted]
PHST- 2018/10/16 06:00 [entrez]
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2018/10/16 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2018.00404 [doi]
PST - epublish
SO  - Front Oncol. 2018 Sep 25;8:404. doi: 10.3389/fonc.2018.00404. eCollection 2018.