PMID- 30320001
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220322
IS  - 2251-6085 (Print)
IS  - 2251-6093 (Electronic)
IS  - 2251-6085 (Linking)
VI  - 47
IP  - 9
DP  - 2018 Sep
TI  - The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is 
      Influenced by Dietary Intake in Elderly Chinese.
PG  - 1272-1280
AB  - BACKGROUND: To examine whether polymorphisms of SIRT1 and dietary product intake 
      can be implicated in type 2 diabetes mellitus (T2DM). METHODS: In this 
      community-based, case-control study, 568 subjects (284 patients and 284 controls) 
      were enrolled in a community located in northern Guangzhou, China. The four 
      polymorphisms of SIRT1 (rs4746720, rs10509291, rs2236319, rs10823116) were 
      examined using TaqMan nuclease technology. The dietary data were collected by an 
      inquiring officer through face-to-face method. RESULTS: The rs4746720 CC+TT 
      genotype had higher risk compared with CT genotype to develop T2DM [odds ratio 
      (OR) =1.42, 95% confidence interval (CI) = 1.02-1.97]. The subjects with 
      rs4746720 CC+TT genotype and eat sugar food over 30g per day increased the risk 
      of T2DM to 2.22(1.21-4.06) times. The subjects with rs4746720 CC+TT genotype and 
      smoking increased the risk of T2DM to 1.65 (1.10-2.47) times. The unhealthy 
      eating habits such as red meat, salty food, use animal fat yielded higher risks 
      of T2DM, the OR of risk of T2DM was 2.89 (1.38-6.01), 2.73 (1.61-4.64) and 
      27.91(9.24-84.32) respectively. However, the milk, soy, white meat, vegetables 
      and low-salt diet decreased the risk of T2DM, the OR of risk of T2DM was 0.51 
      (0.29-0.88), 0.43 (0.26-0.74), 0.51(0.32-0.83), 0.21(0.10-0.44), 0.28(0.12-0.65), 
      0.35(0.21-0.51) respectively. CONCLUSION: Variants in SIRT1 with rs4746720 CC+TT 
      genotype increased the risk of T2DM, especially with the unhealthy eating habits.
FAU - Zhuanping, Zeng
AU  - Zhuanping Z
AD  - School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, 
      China.
FAU - Rifang, Liao
AU  - Rifang L
AD  - Dept. of Pharmacy, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, 
      Guangzhou 510120, China.
FAU - Qing, Chen
AU  - Qing C
AD  - Dept. of Epidemiology, School of Public Health and Tropical Medicine, Southern 
      Medical University, Guangzhou 510515, China.
FAU - Sidong, Chen
AU  - Sidong C
AD  - School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, 
      China.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Public Health
JT  - Iranian journal of public health
JID - 7505531
PMC - PMC6174046
OTO - NOTNLM
OT  - China
OT  - Dietary
OT  - Sirtuin 1
OT  - Type 2 diabetes mellitus
COIS- Conflict of interest The authors declare that there is no conflict of interests.
EDAT- 2018/10/16 06:00
MHDA- 2018/10/16 06:01
PMCR- 2018/09/01
CRDT- 2018/10/16 06:00
PHST- 2018/10/16 06:00 [entrez]
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2018/10/16 06:01 [medline]
PHST- 2018/09/01 00:00 [pmc-release]
AID - ijph-47-1272 [pii]
PST - ppublish
SO  - Iran J Public Health. 2018 Sep;47(9):1272-1280.