PMID- 30320140
OWN - NLM
STAT- MEDLINE
DCOM- 20181227
LR  - 20181227
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2018
DP  - 2018
TI  - Beneficial Effects of Poplar Buds on Hyperglycemia, Dyslipidemia, Oxidative 
      Stress, and Inflammation in Streptozotocin-Induced Type-2 Diabetes.
PG  - 7245956
LID - 10.1155/2018/7245956 [doi]
LID - 7245956
AB  - The effects of propolis on blood glucose regulation and the alleviation of 
      various complications caused by diabetes have been widely studied. The main 
      source of propolis in the northern temperate zone is poplar buds. However, there 
      is limited research on the antidiabetic activity of poplar buds. In order to 
      evaluate the effect of poplar buds on type-2 diabetes, crude extract and 50% 
      fraction of poplar buds were used to feed streptozotocin-induced type-2 diabetic 
      mice. The results showed that 50% fraction could increase insulin sensitivity and 
      reduce insulin resistance, as well as decrease the levels of fasting blood 
      glucose, glycated hemoglobin, and glycosylated serum proteins in diabetic mice. 
      Compared with the model control group, the 50% fraction-treated group showed 
      significant decreases of malondialdehyde (MDA) and increases of superoxide 
      dismutase (SOD) in serum and liver homogenate. Moreover, 50% fraction could 
      significantly decrease total cholesterol (TC), alleviate abnormal lipid 
      metabolism, and enhance antioxidant capacity in the serum. For inflammatory 
      factors, feeding of 50% fraction could also reduce the levels of interleukin 6 
      (IL-6), tumor necrosis factor alpha (TNF-alpha), monocyte chemotactic protein 1 (MCP-1), 
      and cyclooxygenase-2 (COX-2) in liver homogenate. Taken together, our results 
      suggest that crude extract and 50% fraction of poplar buds, particularly the 
      latter, can decrease blood glucose levels and insulin resistance, and 50% 
      fraction can significantly relieve dyslipidemia, oxidative stress, and 
      inflammation caused by type-2 diabetes.
FAU - Peng, Shiqin
AU  - Peng S
AD  - College of Food Science and Technology, Huazhong Agricultural University, Wuhan 
      430070, China.
FAU - Wei, Ping
AU  - Wei P
AD  - College of Food Science and Technology, Huazhong Agricultural University, Wuhan 
      430070, China.
FAU - Lu, Qun
AU  - Lu Q
AUID- ORCID: 0000-0002-6211-6565
AD  - College of Food Science and Technology, Huazhong Agricultural University, Wuhan 
      430070, China.
AD  - Wuhan Engineering Research Center of Bee Products on Quality and Safety Control, 
      Wuhan 430070, China.
AD  - Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural 
      University), Ministry of Education, Wuhan 430070, China.
FAU - Liu, Rui
AU  - Liu R
AUID- ORCID: 0000-0001-5820-0177
AD  - College of Food Science and Technology, Huazhong Agricultural University, Wuhan 
      430070, China.
AD  - Wuhan Engineering Research Center of Bee Products on Quality and Safety Control, 
      Wuhan 430070, China.
AD  - Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural 
      University), Ministry of Education, Wuhan 430070, China.
FAU - Ding, Yue
AU  - Ding Y
AD  - College of Food Science and Technology, Huazhong Agricultural University, Wuhan 
      430070, China.
FAU - Zhang, Jiuliang
AU  - Zhang J
AD  - College of Food Science and Technology, Huazhong Agricultural University, Wuhan 
      430070, China.
AD  - Wuhan Engineering Research Center of Bee Products on Quality and Safety Control, 
      Wuhan 430070, China.
AD  - Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural 
      University), Ministry of Education, Wuhan 430070, China.
LA  - eng
PT  - Journal Article
DEP - 20180918
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 9009-62-5 (Propolis)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
SB  - IM
MH  - Animals
MH  - Cyclooxygenase 2/metabolism
MH  - Cytokines/metabolism
MH  - Diabetes Complications/*drug therapy
MH  - Diabetes Mellitus, Experimental
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Disease Models, Animal
MH  - Dyslipidemias/*drug therapy
MH  - Humans
MH  - Hyperglycemia/*drug therapy
MH  - Inflammation/*drug therapy
MH  - Insulin Resistance
MH  - Liver/*metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Oxidative Stress/drug effects
MH  - Plant Extracts/*therapeutic use
MH  - Populus/immunology
MH  - Propolis/immunology
PMC - PMC6167568
EDAT- 2018/10/16 06:00
MHDA- 2018/12/28 06:00
PMCR- 2018/09/18
CRDT- 2018/10/16 06:00
PHST- 2018/04/11 00:00 [received]
PHST- 2018/07/15 00:00 [revised]
PHST- 2018/07/26 00:00 [accepted]
PHST- 2018/10/16 06:00 [entrez]
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2018/12/28 06:00 [medline]
PHST- 2018/09/18 00:00 [pmc-release]
AID - 10.1155/2018/7245956 [doi]
PST - epublish
SO  - J Immunol Res. 2018 Sep 18;2018:7245956. doi: 10.1155/2018/7245956. eCollection 
      2018.