PMID- 30320486
OWN - NLM
STAT- MEDLINE
DCOM- 20190429
LR  - 20210109
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 33
IP  - 3
DP  - 2019 Mar
TI  - The association between albumin-dNLR score and disease activity in patients with 
      rheumatoid arthritis.
PG  - e22695
LID - 10.1002/jcla.22695 [doi]
LID - e22695
AB  - BACKGROUND: Recently, clinical studies have described an association between 
      albumin and the derived neutrophil to lymphocyte ratio (dNLR) with several 
      diseases. This study was aimed to investigate the albumin-dNLR (ALB-dNLR) score 
      in rheumatoid arthritis (RA) patients and assess its relationship with clinical 
      and laboratory parameters of RA. METHODS: We retrospectively enrolled 127 RA 
      patients, 155 osteoarthritis (OA) patients, and 155 healthy controls. The 
      ALB-dNLR score was based on serum albumin level, neutrophil count, and white cell 
      count. The Spearman's rank test was used to measure the correlations between 
      ALB-dNLR score and disease activity as well as laboratory indexes. RESULTS: The 
      ALB-dNLR score was significantly higher in RA patients than in OA patients 
      (P < 0.001) and in healthy controls (P < 0.001). The proportion of higher 
      ALB-dNLR score has been raised along with increased disease activity (P < 0.001). 
      The Spearman's rank test showed that ALB-dNLR score was positively associated 
      with DAS28 score, CRP, ESR, IgA, and platelet count. Moreover, the receiver 
      operating characteristic (ROC) curve showed that the area under the curve (AUC) 
      of ALB-dNLR was 0.693 (95% CI: 0.631-0.755), which was higher than that of 
      albumin (AUC: 0.625, 95% CI: 0.559-0.692) and dNLR (AUC: 0.680, 95% CI: 
      0.617-0.743) alone. CONCLUSIONS: The results demonstrate that the ALB-dNLR score 
      increased in RA patients. The ALB-dNLR score may be a useful marker to estimate 
      the disease activity of RA patients.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Chen, Shuaishuai
AU  - Chen S
AD  - Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou 
      Enze Medical Center (Group), Linhai, China.
FAU - Ying, Haijian
AU  - Ying H
AD  - Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou 
      Enze Medical Center (Group), Linhai, China.
FAU - Du, Juping
AU  - Du J
AD  - Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou 
      Enze Medical Center (Group), Linhai, China.
FAU - Zhu, Xiaoli
AU  - Zhu X
AD  - Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou 
      Enze Medical Center (Group), Linhai, China.
FAU - Shi, Jianfeng
AU  - Shi J
AD  - Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou 
      Enze Medical Center (Group), Linhai, China.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Wenzhou 
      Medical University, Linhai, China.
FAU - Chen, Shiyong
AU  - Chen S
AD  - Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou 
      Enze Medical Center (Group), Linhai, China.
FAU - Shen, Bo
AU  - Shen B
AD  - Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou 
      Enze Medical Center (Group), Linhai, China.
FAU - Li, Jun
AU  - Li J
AUID- ORCID: 0000-0002-9061-7578
AD  - Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou 
      Enze Medical Center (Group), Linhai, China.
LA  - eng
GR  - 2016KYB328/Zhejiang Medical and Health Science and Technology Plan/
GR  - 2018RC016/Zhejiang Medical and Health Science and Technology Plan/
GR  - 1702KY02/The Science and Technology Plans of Taizhou City/
PT  - Journal Article
DEP - 20181015
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Area Under Curve
MH  - Arthritis, Rheumatoid/blood/*epidemiology/immunology
MH  - Female
MH  - Humans
MH  - Leukocyte Count
MH  - Lymphocytes/*physiology
MH  - Male
MH  - Middle Aged
MH  - Neutrophils/*physiology
MH  - Osteoarthritis/blood/epidemiology
MH  - Retrospective Studies
MH  - Serum Albumin/*analysis
PMC - PMC6818584
OTO - NOTNLM
OT  - DAS28 score
OT  - albumin-dNLR score
OT  - disease activity
OT  - rheumatoid arthritis
EDAT- 2018/10/16 06:00
MHDA- 2019/04/30 06:00
PMCR- 2018/10/15
CRDT- 2018/10/16 06:00
PHST- 2018/07/26 00:00 [received]
PHST- 2018/09/21 00:00 [revised]
PHST- 2018/09/21 00:00 [accepted]
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2019/04/30 06:00 [medline]
PHST- 2018/10/16 06:00 [entrez]
PHST- 2018/10/15 00:00 [pmc-release]
AID - JCLA22695 [pii]
AID - 10.1002/jcla.22695 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2019 Mar;33(3):e22695. doi: 10.1002/jcla.22695. Epub 2018 Oct 
      15.