PMID- 30320945
OWN - NLM
STAT- MEDLINE
DCOM- 20200317
LR  - 20200317
IS  - 1522-2594 (Electronic)
IS  - 0740-3194 (Print)
IS  - 0740-3194 (Linking)
VI  - 81
IP  - 3
DP  - 2019 Mar
TI  - Multipathway multi-echo (MPME) imaging: all main MR parameters mapped based on a 
      single 3D scan.
PG  - 1699-1713
LID - 10.1002/mrm.27525 [doi]
AB  - PURPOSE: Quantitative parameter maps, as opposed to qualitative grayscale images, 
      may represent the future of diagnostic MRI. A new quantitative MRI method is 
      introduced here that requires a single 3D acquisition, allowing good spatial 
      coverage to be achieved in relatively short scan times. METHODS: A multipathway 
      multi-echo sequence was developed, and at least 3 pathways with 2 TEs were needed 
      to generate T(1) , T(2) , T(2)(*) , B(1)(+) , and B(0) maps. The method required 
      the central k-space region to be sampled twice, with the same sequence but with 2 
      very different nominal flip angle settings. Consequently, scan time was only 
      slightly longer than that of a single scan. The multipathway multi-echo data were 
      reconstructed into parameter maps, for phantom as well as brain acquisitions, in 
      5 healthy volunteers at 3 T. Spatial resolution, matrix size, and FOV were 1.2 x 
      1.0 x 1.2 mm(3) , 160 x 192 x 160, and 19.2 x 19.2 x 19.2 cm(3) (whole brain), 
      acquired in 11.5 minutes with minimal acceleration. Validation was performed 
      against T(1) , T(2) , and T(2)(*) maps calculated from gradient-echo and 
      spin-echo data. RESULTS: In Bland-Altman plots, bias and limits of agreement for 
      T(1) and T(2) results in vivo and in phantom were -2.9/+/-125.5 ms (T(1) in vivo), 
      -4.8/+/-20.8 ms (T(2) in vivo), -1.5/+/-18.1 ms (T(1) in phantom), and -5.3/+/-7.4 ms 
      (T(2) in phantom), for regions of interest including given brain structures or 
      phantom compartments. Due to relatively high noise levels, the current 
      implementation of the approach may prove more useful for region of interest-based 
      as opposed to pixel-based interpretation. CONCLUSIONS: We proposed a novel 
      approach to quantitatively map MR parameters based on a multipathway multi-echo 
      acquisition.
CI  - (c) 2018 International Society for Magnetic Resonance in Medicine.
FAU - Cheng, Cheng-Chieh
AU  - Cheng CC
AUID- ORCID: 0000-0001-5833-5661
AD  - Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, Massachusetts.
FAU - Preiswerk, Frank
AU  - Preiswerk F
AD  - Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, Massachusetts.
FAU - Hoge, W Scott
AU  - Hoge WS
AD  - Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, Massachusetts.
FAU - Kuo, Tai-Hsin
AU  - Kuo TH
AD  - Department of Imaging Systems, Philips Healthcare, Taipei, Taiwan.
FAU - Madore, Bruno
AU  - Madore B
AD  - Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, Massachusetts.
LA  - eng
GR  - R21 EB019500/EB/NIBIB NIH HHS/United States
GR  - P41 EB015898/EB/NIBIB NIH HHS/United States
GR  - R21EB019500/GF/NIH HHS/United States
GR  - P41EB015898/GF/NIH HHS/United States
GR  - R01CA149342/GF/NIH HHS/United States
GR  - R01 CA149342/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20181015
PL  - United States
TA  - Magn Reson Med
JT  - Magnetic resonance in medicine
JID - 8505245
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Brain/*diagnostic imaging
MH  - Brain Mapping
MH  - Computer Simulation
MH  - *Echo-Planar Imaging
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Image Processing, Computer-Assisted/*methods
MH  - Imaging, Three-Dimensional/*methods
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Models, Statistical
MH  - Phantoms, Imaging
MH  - Young Adult
PMC - PMC6347518
MID - NIHMS986644
OTO - NOTNLM
OT  - multipathway imaging
OT  - quantitative MRI
OT  - relaxometry
EDAT- 2018/10/16 06:00
MHDA- 2020/03/18 06:00
PMCR- 2020/03/01
CRDT- 2018/10/16 06:00
PHST- 2018/05/14 00:00 [received]
PHST- 2018/08/15 00:00 [revised]
PHST- 2018/08/18 00:00 [accepted]
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2020/03/18 06:00 [medline]
PHST- 2018/10/16 06:00 [entrez]
PHST- 2020/03/01 00:00 [pmc-release]
AID - 10.1002/mrm.27525 [doi]
PST - ppublish
SO  - Magn Reson Med. 2019 Mar;81(3):1699-1713. doi: 10.1002/mrm.27525. Epub 2018 Oct 
      15.