PMID- 30321074
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 1532-4311 (Electronic)
IS  - 0882-0139 (Linking)
VI  - 48
IP  - 2
DP  - 2019 Feb
TI  - Adipokines in Multiple Sclerosis Patients with and without Optic Neuritis as the 
      First Clinical Presentation.
PG  - 190-197
LID - 10.1080/08820139.2018.1528270 [doi]
AB  - BACKGROUND: Adipocytokines have been implied to be involved in multiple sclerosis 
      (MS) pathogenesis. MS patients whose first clinical episode is optic neuritis 
      (ON) have been reported to display a milder disease course. In this study, we 
      aimed to show whether this milder disease course is related to reduced adipokine 
      production. METHODS: A total of 55 (24 with ON as the first clinical episode) 
      relapsing-remitting MS (RRMS) patients and 40 healthy individuals were recruited. 
      Concentrations of adipokines were measured in sera by ELISA. RESULTS: The levels 
      of adiponectin, leptin, resistin, monocyte chemoattractant protein-1 (MCP-1) and 
      IL-8 were significantly higher in RRMS patients compared with healthy controls. 
      RRMS cases starting with ON had lower expanded disability status scale scores. 
      Serum adiponectin, leptin, resistin and MCP-1 levels were significantly lower in 
      MS patients, whose first clinical episode was ON. CONCLUSIONS: MS patients with 
      ON as the first manifestation display both lower disability scores and reduced 
      serum adipokine levels implying that adipocytokine production is associated with 
      MS progression. Exact mechanisms of this association in MS patients with first 
      episode ON need to be further studied.
FAU - Duzel, Berna
AU  - Duzel B
AD  - a Department of Neurology, Faculty of Medicine , Dicle University , Diyarbakir , 
      Turkey.
FAU - Tamam, Yusuf
AU  - Tamam Y
AUID- ORCID: 0000-0002-9886-2017
AD  - a Department of Neurology, Faculty of Medicine , Dicle University , Diyarbakir , 
      Turkey.
FAU - Coban, Arzu
AU  - Coban A
AD  - b Department of Neurology, Istanbul Faculty of Medicine , Istanbul University , 
      Istanbul , Turkey.
FAU - Tuzun, Erdem
AU  - Tuzun E
AUID- ORCID: 0000-0002-4483-0394
AD  - c Department of Neuroscience Institute for Experimental Medicine , Istanbul 
      University , Istanbul , Turkey.
LA  - eng
PT  - Journal Article
DEP - 20181015
PL  - England
TA  - Immunol Invest
JT  - Immunological investigations
JID - 8504629
RN  - 0 (Adipokines)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adipokines/*metabolism
MH  - Adult
MH  - Biomarkers
MH  - Cytokines/metabolism
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/metabolism
MH  - Male
MH  - Multiple Sclerosis/*complications/diagnosis/*metabolism
MH  - Optic Neuritis/diagnosis/*etiology
MH  - Phenotype
OTO - NOTNLM
OT  - Adipokine
OT  - disability
OT  - first clinical episode
OT  - multiple sclerosis
OT  - optic neuritis
EDAT- 2018/10/16 06:00
MHDA- 2019/05/21 06:00
CRDT- 2018/10/16 06:00
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2018/10/16 06:00 [entrez]
AID - 10.1080/08820139.2018.1528270 [doi]
PST - ppublish
SO  - Immunol Invest. 2019 Feb;48(2):190-197. doi: 10.1080/08820139.2018.1528270. Epub 
      2018 Oct 15.