PMID- 30321576
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20191210
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 690
DP  - 2019 Jan 18
TI  - The effect of the anti-diabetic drug metformin on behavioral manifestations 
      associated with ovariectomy in mice.
PG  - 95-98
LID - S0304-3940(18)30700-6 [pii]
LID - 10.1016/j.neulet.2018.10.024 [doi]
AB  - The aim of this study was to evaluate the anti-diabetic drug metformin (Met) 
      effects on the anxiety and cognitive impairment in ovariectomized mice. 
      Thirty-two female adult mice were distributed into four groups: control, sham 
      ovariectomy, ovariectomy + Met 7 mg/kg and ovariectomy + Met 15 mg/kg. The 
      vaginal cytology was used to confirm the ovariectomy surgery. Anxiety was 
      monitored using elevated plus maze test and cognitive function was assessed by 
      novel object recognition task. Animal's brains were analyzed for the 
      brain-derived neurotrophic factor (BDNF). Our results demonstrated that 
      ovariectomy caused cognitive impairments and anxiety, as well as decreased BDNF 
      levels. Moreover, administration of Met improves ovariectomy-related disorders 
      such as cognitive impairments and anxiety, as well as increased BDNF levels. The 
      results of the present study suggest that Met could be used as a novel 
      therapeutic strategy for the treatment of ovariectomy-related conditions.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Fatemi, Iman
AU  - Fatemi I
AD  - Physiology-Pharmacology Research Center, Research Institute of Basic Medical 
      Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department 
      of Physiology and Pharmacology, School of Medicine, Rafsanjan University of 
      Medical Sciences, Rafsanjan, Iran.
FAU - Delrobaee, Fatemeh
AU  - Delrobaee F
AD  - Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, 
      Iran.
FAU - Bahmani, Maryam
AU  - Bahmani M
AD  - Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, 
      Iran.
FAU - Shamsizadeh, Ali
AU  - Shamsizadeh A
AD  - Physiology-Pharmacology Research Center, Research Institute of Basic Medical 
      Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department 
      of Physiology and Pharmacology, School of Medicine, Rafsanjan University of 
      Medical Sciences, Rafsanjan, Iran.
FAU - Allahtavakoli, Mohammad
AU  - Allahtavakoli M
AD  - Physiology-Pharmacology Research Center, Research Institute of Basic Medical 
      Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department 
      of Physiology and Pharmacology, School of Medicine, Rafsanjan University of 
      Medical Sciences, Rafsanjan, Iran. Electronic address: m_alahtavakoli@rums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181012
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Hypoglycemic Agents)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hypoglycemic Agents/*pharmacology
MH  - Maze Learning/*drug effects
MH  - Metformin/*pharmacology
MH  - Mice
MH  - Ovariectomy/*psychology
MH  - Recognition, Psychology/*drug effects
OTO - NOTNLM
OT  - Anxiety
OT  - Cognition
OT  - Metformin
OT  - Ovariectomy
EDAT- 2018/10/16 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/10/16 06:00
PHST- 2018/07/01 00:00 [received]
PHST- 2018/10/06 00:00 [revised]
PHST- 2018/10/11 00:00 [accepted]
PHST- 2018/10/16 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/10/16 06:00 [entrez]
AID - S0304-3940(18)30700-6 [pii]
AID - 10.1016/j.neulet.2018.10.024 [doi]
PST - ppublish
SO  - Neurosci Lett. 2019 Jan 18;690:95-98. doi: 10.1016/j.neulet.2018.10.024. Epub 
      2018 Oct 12.