PMID- 30322026
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20190114
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 10
DP  - 2018 Oct 12
TI  - Relationship between Serum BDNF Levels and Depressive Mood in Subacute Stroke 
      Patients: A Preliminary Study.
LID - 10.3390/ijms19103131 [doi]
LID - 3131
AB  - The aim of this preliminary study was to investigate the potential of serum 
      brain-derived neurotrophic factor (BDNF) as a biomarker in poststroke depressive 
      mood in subacute stroke patients. Thirty-eight subacute stroke patients were 
      recruited in this study. All participants underwent the standard rehabilitation 
      program that included 2 h of physical therapy daily and 1 h of occupational 
      therapy five days a week. The rehabilitation period lasted two weeks during the 
      subacute stroke phase. We measured the serum BDNF, proBDNF, and matrix 
      metalloproteinase-9 before and one and two weeks after the standard 
      rehabilitation program. In addition, all participants were assessed using the 
      Geriatric Depression Scale-Short Form (GDS-SF) for depressive mood at three time 
      points. Pearson correlation analysis was performed to determine the relationship 
      between serum BDNF levels and the GDS-SF. The GDS-SF showed significant 
      improvement during the standard rehabilitation program period (p < 0.05). The 
      GDS-SF was significantly correlated with serum BDNF levels at each time point (p 
      < 0.05). These results suggest that serum BDNF may be used as a biomarker for 
      depressive mood in subacute stroke patients. However, further studies with larger 
      study populations are needed to clarify these results.
FAU - Chang, Won Hyuk
AU  - Chang WH
AUID- ORCID: 0000-0002-4969-7895
AD  - Department of Physical and Rehabilitation Medicine, Center for Prevention and 
      Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul 06351, Korea. 
      wh.chang@samsung.com.
FAU - Shin, Min A
AU  - Shin MA
AD  - Department of Physical and Rehabilitation Medicine, Center for Prevention and 
      Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul 06351, Korea. 
      minari5995.shin@samsung.com.
FAU - Lee, Ahee
AU  - Lee A
AD  - Department of Health Science and Technology, Department of Medical Device 
      Management & Research, Department of Digital Health, SAIHST, Sungkyunkwan 
      University, Seoul 06351, Korea. ahee.lee@gmail.com.
FAU - Kim, Heegoo
AU  - Kim H
AD  - Department of Health Science and Technology, Department of Medical Device 
      Management & Research, Department of Digital Health, SAIHST, Sungkyunkwan 
      University, Seoul 06351, Korea. hiheegoo@gmail.com.
FAU - Kim, Yun-Hee
AU  - Kim YH
AD  - Department of Physical and Rehabilitation Medicine, Center for Prevention and 
      Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul 06351, Korea. yunkim@skku.edu.
AD  - Department of Health Science and Technology, Department of Medical Device 
      Management & Research, Department of Digital Health, SAIHST, Sungkyunkwan 
      University, Seoul 06351, Korea. yunkim@skku.edu.
LA  - eng
GR  - NRF-2014R1A2A1A01005128/the Korea government (MSIP)/
GR  - NRF-2017R1A2A1A05000730/the Korea government (MSIP)/
PT  - Journal Article
DEP - 20181012
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Depression/blood/etiology/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stroke/blood/metabolism/*psychology
MH  - Stroke Rehabilitation/*methods
MH  - Treatment Outcome
PMC - PMC6213140
OTO - NOTNLM
OT  - BDNF
OT  - depression
OT  - neurotrophic factor
OT  - stroke
COIS- The authors declare no conflict of interest.
EDAT- 2018/10/17 06:00
MHDA- 2019/01/15 06:00
PMCR- 2018/10/01
CRDT- 2018/10/17 06:00
PHST- 2018/09/19 00:00 [received]
PHST- 2018/10/09 00:00 [revised]
PHST- 2018/10/10 00:00 [accepted]
PHST- 2018/10/17 06:00 [entrez]
PHST- 2018/10/17 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
PHST- 2018/10/01 00:00 [pmc-release]
AID - ijms19103131 [pii]
AID - ijms-19-03131 [pii]
AID - 10.3390/ijms19103131 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Oct 12;19(10):3131. doi: 10.3390/ijms19103131.