PMID- 30322169
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 10
DP  - 2018 Oct 13
TI  - BDNF, Brain, and Regeneration: Insights from Zebrafish.
LID - 10.3390/ijms19103155 [doi]
LID - 3155
AB  - Zebrafish (Danio rerio) is a teleost fish widely accepted as a model organism for 
      neuroscientific studies. The adults show common basic vertebrate brain 
      structures, together with similar key neuroanatomical and neurochemical pathways 
      of relevance to human diseases. However, the brain of adult zebrafish possesses, 
      differently from mammals, intense neurogenic activity, which can be correlated 
      with high regenerative properties. Brain derived neurotrophic factor (BDNF), a 
      member of the neurotrophin family, has multiple roles in the brain, due also to 
      the existence of several biologically active isoforms, that interact with 
      different types of receptors. BDNF is well conserved in the vertebrate evolution, 
      with the primary amino acid sequences of zebrafish and human BDNF being 91% 
      identical. Here, we review the available literature regarding BDNF in the 
      vertebrate brain and the potential involvement of BDNF in telencephalic 
      regeneration after injury, with particular emphasis to the zebrafish. Finally, we 
      highlight the potential of the zebrafish brain as a valuable model to add new 
      insights on future BDNF studies.
FAU - Lucini, Carla
AU  - Lucini C
AUID- ORCID: 0000-0003-2216-6338
AD  - Department of Veterinary Medicine, University of Naples Federico II, 80137 
      Naples, Italy. carla.lucini@unina.it.
FAU - D'Angelo, Livia
AU  - D'Angelo L
AUID- ORCID: 0000-0001-5050-642X
AD  - Department of Veterinary Medicine, University of Naples Federico II, 80137 
      Naples, Italy. livia.dangelo@unina.it.
AD  - Stazione Zoologica Anton Dohrn, 80122 Naples, Italy. livia.dangelo@unina.it.
FAU - Cacialli, Pietro
AU  - Cacialli P
AD  - Department of Veterinary Medicine, University of Naples Federico II, 80137 
      Naples, Italy. Pietro.Cacialli@unige.ch.
FAU - Palladino, Antonio
AU  - Palladino A
AD  - Centro Ricerche Interdipartimentali sui Biomateriali, University of Naples 
      FedericoII, 80125 Naples, Italy. a.palladino1986@gmail.com.
FAU - de Girolamo, Paolo
AU  - de Girolamo P
AD  - Department of Veterinary Medicine, University of Naples Federico II, 80137 
      Naples, Italy. paolo.degirolamo@unina.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181013
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Zebrafish Proteins)
SB  - IM
MH  - Animals
MH  - Brain/growth & development/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics/*metabolism
MH  - Gene Expression Regulation
MH  - Models, Animal
MH  - Neurogenesis
MH  - Telencephalon/enzymology/metabolism
MH  - Zebrafish/*growth & development/metabolism
MH  - Zebrafish Proteins/genetics/metabolism
PMC - PMC6214035
OTO - NOTNLM
OT  - Fish
OT  - Trk B
OT  - neuroregeneration
OT  - neurotrophins
OT  - p75
COIS- The authors declare no conflict of interest.
EDAT- 2018/10/17 06:00
MHDA- 2019/01/29 06:00
PMCR- 2018/10/01
CRDT- 2018/10/17 06:00
PHST- 2018/09/26 00:00 [received]
PHST- 2018/10/10 00:00 [revised]
PHST- 2018/10/11 00:00 [accepted]
PHST- 2018/10/17 06:00 [entrez]
PHST- 2018/10/17 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2018/10/01 00:00 [pmc-release]
AID - ijms19103155 [pii]
AID - ijms-19-03155 [pii]
AID - 10.3390/ijms19103155 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Oct 13;19(10):3155. doi: 10.3390/ijms19103155.