PMID- 30322212 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231004 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 7 IP - 10 DP - 2018 Oct 14 TI - Addressing Opioid-Related Chemical Coping in Long-Term Opioid Therapy for Chronic Noncancer Pain: A Multicenter, Observational, Cross-Sectional Study. LID - 10.3390/jcm7100354 [doi] LID - 354 AB - Opioid consumption has increased worldwide, which carries the risk of opioid use disorder (OUD). However, the literature on OUD and opioid-related chemical coping (OrCC) in chronic noncancer pain (CNCP) is heterogeneous, with most studies conducted in the United States. We performed a multicenter, observational, cross-sectional study to address OrCC in long-term opioid therapy (LtOT) for CNCP in South Korea. The objectives were to determine the frequency and predictors of OrCC. We included 258 patients. Among them, fifty-five (21%) patients showed OrCC. The sample had high pain catastrophizing (>/=30 points; 66%), moderate-severe insomnia (>/=15 points; 63%), low resilience (68 points), and high suicidal ideation (67%). OrCC patients had greater pain interference (85.18% vs. 58.28%, p = 0.017) and lower satisfaction with the LtOT (56.4% vs. 78.3%, p = 0.002). In multivariable analysis, alcohol abuse (OR = 6.84, p = 0.001), prescription drugs abuse (OR = 19.32, p = 0.016), functional pain (OR = 12.96, p < 0.001), head and neck pain (OR = 2.48, p = 0.039), MEDD (morphine equivalent daily dose) >/= 200 mg/day (OR = 3.48, p = 0.006), and ongoing litigation (OR = 2.33, p = 0.047) were significant predictors of OrCC. In conclusion, the break-out of OrCC in CNCP in South Korea was comparable to those in countries with high opioid consumption, such as the United States, regardless of the country's opioid consumption rate. FAU - Castaneda, Anyela Marcela AU - Castaneda AM AD - Department of Anesthesiology and Pain Medicine, Seoul National University Hospital College of Medicine, 101Daehak-ro, Jongno-gu, Seoul 03080, Korea. anymarcey@hotmail.com. FAU - Lee, Chang-Soon AU - Lee CS AD - Department of Anesthesiology and Pain Medicine, Seoul National University Hospital College of Medicine, 101Daehak-ro, Jongno-gu, Seoul 03080, Korea. iparid@gmail.com. FAU - Kim, Yong-Chul AU - Kim YC AD - Department of Anesthesiology and Pain Medicine, Seoul National University Hospital College of Medicine, 101Daehak-ro, Jongno-gu, Seoul 03080, Korea. pain@snu.ac.kr. FAU - Lee, Dasom AU - Lee D AUID- ORCID: 0000-0003-3776-2263 AD - Department of Psychiatry, Seoul National University Hospital College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea. ds.elena.lee@gmail.com. FAU - Moon, Jee Youn AU - Moon JY AUID- ORCID: 0000-0001-5551-7750 AD - Department of Anesthesiology and Pain Medicine, Seoul National University Hospital College of Medicine, 101Daehak-ro, Jongno-gu, Seoul 03080, Korea. jymoon0901@gmail.com. AD - Department of Integrated Cancer Care Center, Seoul National University Cancer Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea. jymoon0901@gmail.com. LA - eng PT - Journal Article DEP - 20181014 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC6210168 OTO - NOTNLM OT - chemical coping OT - chronic noncancer pain OT - frequency OT - long-term opioids OT - opioid use disorder OT - opioids OT - risk factors COIS- The authors declare no conflicts of interests with respect to this research, authorship, and/or publication of the article. The funding agency had no role in the design of the study; the collection, execution, analyses, or interpretation of the data; in the writing of the manuscript, or in the decision to publish the results. EDAT- 2018/10/17 06:00 MHDA- 2018/10/17 06:01 PMCR- 2018/10/14 CRDT- 2018/10/17 06:00 PHST- 2018/09/01 00:00 [received] PHST- 2018/10/10 00:00 [revised] PHST- 2018/10/13 00:00 [accepted] PHST- 2018/10/17 06:00 [entrez] PHST- 2018/10/17 06:00 [pubmed] PHST- 2018/10/17 06:01 [medline] PHST- 2018/10/14 00:00 [pmc-release] AID - jcm7100354 [pii] AID - jcm-07-00354 [pii] AID - 10.3390/jcm7100354 [doi] PST - epublish SO - J Clin Med. 2018 Oct 14;7(10):354. doi: 10.3390/jcm7100354.