PMID- 30322807
OWN - NLM
STAT- MEDLINE
DCOM- 20181218
LR  - 20181218
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 214
IP  - 12
DP  - 2018 Dec
TI  - Long-noncoding RNA IFNG-AS1 exerts oncogenic properties by interacting with 
      epithelial splicing regulatory protein 2 (ESRP2) in pituitary adenomas.
PG  - 2054-2061
LID - S0344-0338(18)30885-9 [pii]
LID - 10.1016/j.prp.2018.09.023 [doi]
AB  - Despite the enormous development of medical technologies in recent decades, 
      pituitary adenoma (PA) remains among the most refractory cancers in the world. 
      Elucidating the molecular mechanisms underlying the pathology of PA is essential 
      to identify new treatments for PA. In the present study, we found that IFNG-AS1 
      expression was significantly higher in PA tissues than in nontumor tissues via 
      qRT-PCR and RNA fluorescence in situ hybridization (FISH). shRNA-mediated 
      IFNG-AS1 knockdown in HP75 cells significantly inhibited tumor progression, and 
      IFNG-AS1 overexpression remarkably promoted tumor progression. Epithelial 
      splicing regulatory protein 2 (ESRP2) was demonstrated to be a target protein of 
      IFNG-AS1 in PA; knocking down ESRP2 reversed the tumor-inhibitory effects of 
      IFNG-AS1 knockdown, and overexpressing ESRP2 abolished the tumor-promoting 
      effects of IFNG-AS1 overexpression in HP75 cells. In conclusion, our findings 
      suggested that IFNG-AS1 may function as an oncogene in PA by interacting with 
      ESRP2.
CI  - Copyright (c) 2018 Elsevier GmbH. All rights reserved.
FAU - Lu, Guohui
AU  - Lu G
AD  - Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, 
      Nanchang 330006, China.
FAU - Duan, Jian
AU  - Duan J
AD  - Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, 
      Nanchang 330006, China.
FAU - Zhou, Dongwei
AU  - Zhou D
AD  - Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, 
      Nanchang 330006, China. Electronic address: doc_zhoudw@21cn.com.
LA  - eng
PT  - Journal Article
DEP - 20180929
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (ESRP2 protein, human)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Adenoma/*metabolism/pathology
MH  - Apoptosis/physiology
MH  - Carcinogenesis/*metabolism/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/physiology
MH  - Cell Proliferation/*physiology
MH  - Humans
MH  - Pituitary Neoplasms/*metabolism/pathology
MH  - RNA, Long Noncoding/genetics/*metabolism
MH  - RNA-Binding Proteins/genetics/*metabolism
OTO - NOTNLM
OT  - Epithelial splicing regulatory protein 2 (ESRP2)
OT  - Long noncoding RNA IFNG-AS1 (IFNG-AS1)
OT  - Oncogene
OT  - Pituitary adenoma (PA)
EDAT- 2018/10/17 06:00
MHDA- 2018/12/19 06:00
CRDT- 2018/10/17 06:00
PHST- 2018/07/16 00:00 [received]
PHST- 2018/09/12 00:00 [revised]
PHST- 2018/09/28 00:00 [accepted]
PHST- 2018/10/17 06:00 [pubmed]
PHST- 2018/12/19 06:00 [medline]
PHST- 2018/10/17 06:00 [entrez]
AID - S0344-0338(18)30885-9 [pii]
AID - 10.1016/j.prp.2018.09.023 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2018 Dec;214(12):2054-2061. doi: 10.1016/j.prp.2018.09.023. 
      Epub 2018 Sep 29.