PMID- 30323770
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 9
DP  - 2018
TI  - High-Intensity Interval Training Is Associated With Alterations in Blood 
      Biomarkers Related to Brain Injury.
PG  - 1367
LID - 10.3389/fphys.2018.01367 [doi]
LID - 1367
AB  - Purpose: Blood biomarkers are a useful tool to study concussion. However, their 
      interpretation is complicated by a number of potential biological confounds, 
      including exercise. This is particularly relevant in military and athletic 
      settings where injury commonly occurs during physical exertion. The impact of 
      high-intensity interval training (HIIT) on putative brain injury biomarkers 
      remains under-examined. The purpose of this study was to observe the effects of 
      HIIT on a panel of blood biomarkers associated with brain injury. Methods: Eleven 
      healthy, recreationally active males (median age = 29.0, interquartile range = 
      26.0-31.5) performed HIIT on a bicycle ergometer (8-12 x 60-s intervals at 100% 
      of peak power output, interspersed by 75-s recovery at 50 W) three times/week for 
      2 weeks. Peripheral blood samples were collected before and immediately after 
      HIIT during the first and last training sessions. Plasma concentrations of s100 
      calcium-binding protein beta (S100B), glial fibrillary acidic protein (GFAP), 
      neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF), 
      neurogranin (NRGN), peroxiredoxin (PRDX)-6, creatine kinase-BB isoenzyme (CKBB), 
      visinin-like protein (VILIP)-1, von Willebrand factor (vWF), monocyte 
      chemoattractant protein (MCP)-1, matrix metalloproteinase (MMP)-9, and total tau 
      (T-tau) were quantitated by high-sensitivity MULTI-SPOT((R)) immunoassay, on the 
      MesoScale Diagnostics electrochemiluminescence detection platform. Differences in 
      biomarker concentrations in response to HIIT were evaluated by partial least 
      squares discriminant analysis (PLSDA) within a repeated-measures bootstrapped 
      framework. Results: Ten of 12 biomarkers were increased pre-to-post HIIT; VILIP-1 
      remained unchanged, and GFAP was not statistically evaluated due to insufficient 
      detectability. After 2 weeks of HIIT, T-tau was no longer significantly elevated 
      pre-to-post HIIT, and significant attenuation was noted in the acute responses of 
      NRGN, PRDX-6, MMP-9, and vWF. In addition, compared to session 1, session 6 
      pre-exercise concentrations of NSE and VILIP-1 were significantly lower and 
      higher, respectively. Conclusion: Blood biomarkers commonly associated with brain 
      injury are significantly elevated in response to a single bout of HIIT. After a 
      2-week, six-session training protocol, this response was attenuated for some, but 
      not all markers. While biomarkers continue to provide promise to concussion 
      research, future studies are necessary to disentangle the common biological 
      sequelae to both exercise and brain injury.
FAU - Di Battista, Alex P
AU  - Di Battista AP
AD  - Defence Research and Development Canada, Toronto Research Centre, Toronto, ON, 
      Canada.
AD  - Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, 
      Canada.
FAU - Moes, Katherine A
AU  - Moes KA
AD  - Defence Research and Development Canada, Toronto Research Centre, Toronto, ON, 
      Canada.
FAU - Shiu, Maria Y
AU  - Shiu MY
AD  - Defence Research and Development Canada, Toronto Research Centre, Toronto, ON, 
      Canada.
FAU - Hutchison, Michael G
AU  - Hutchison MG
AD  - Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, 
      Canada.
AD  - Neuroscience Program, Keenan Research Centre for Biomedical Science of St. 
      Michael's Hospital, Toronto, ON, Canada.
FAU - Churchill, Nathan
AU  - Churchill N
AD  - Neuroscience Program, Keenan Research Centre for Biomedical Science of St. 
      Michael's Hospital, Toronto, ON, Canada.
FAU - Thomas, Scott G
AU  - Thomas SG
AD  - Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, 
      Canada.
FAU - Rhind, Shawn G
AU  - Rhind SG
AD  - Defence Research and Development Canada, Toronto Research Centre, Toronto, ON, 
      Canada.
AD  - Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, 
      Canada.
LA  - eng
PT  - Journal Article
DEP - 20180928
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6172320
OTO - NOTNLM
OT  - MTBI
OT  - PRDX-6
OT  - S100B
OT  - military medicine
OT  - sport concussion
OT  - tau
EDAT- 2018/10/17 06:00
MHDA- 2018/10/17 06:01
PMCR- 2018/09/28
CRDT- 2018/10/17 06:00
PHST- 2018/06/01 00:00 [received]
PHST- 2018/09/10 00:00 [accepted]
PHST- 2018/10/17 06:00 [entrez]
PHST- 2018/10/17 06:00 [pubmed]
PHST- 2018/10/17 06:01 [medline]
PHST- 2018/09/28 00:00 [pmc-release]
AID - 10.3389/fphys.2018.01367 [doi]
PST - epublish
SO  - Front Physiol. 2018 Sep 28;9:1367. doi: 10.3389/fphys.2018.01367. eCollection 
      2018.