PMID- 30323965
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2156-6976 (Print)
IS  - 2156-6976 (Electronic)
IS  - 2156-6976 (Linking)
VI  - 8
IP  - 9
DP  - 2018
TI  - A positive feedback regulation between long noncoding RNA SNHG1 and YAP1 
      modulates growth and metastasis in laryngeal squamous cell carcinoma.
PG  - 1712-1724
AB  - Laryngeal squamous cell carcinoma (LSCC) is the second highest incidence among 
      the head and neck malignancies. Long noncoding RNA (lncRNA) small nucleolar RNA 
      host gene 1 (SNHG1) functions as an oncogene in various human cancers. However, 
      the biological functions and molecular mechanisms of SNHG1 in LSCC have not been 
      reported. In this study, we found that lncRNA SNHG1 is significantly upregulated 
      in LSCC and associated with prognosis of LSCC patients. Knockdown of SNHG1 
      inhibited cell proliferation, migration and invasion and induced cell apoptosis. 
      In addition, knockdown of SNHG1 inhibits LSCC growth and metastasis in vivo. 
      Mechanistically, SNHG1 promotes YAP1 expression and Hippo signaling activity by 
      competitively sponging miR-375. Moreover, YAP1 could occupy the SNHG1 promoter to 
      enhance its transcription, suggesting that there exists a positive feedback 
      regulation between YAP1 and SNHG1. Collectively, our study first elucidates the 
      mechanism of SNHG1-mediated malignant phenotypes through evoking the 
      miR-375/YAP1/Hippo signalling axis, which provides a novel target for LSCC 
      treatment.
FAU - Gao, Ling
AU  - Gao L
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Zhengzhou 
      University Zhengzhou 450052, Henan Province, PR China.
FAU - Cao, Hua
AU  - Cao H
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Zhengzhou 
      University Zhengzhou 450052, Henan Province, PR China.
FAU - Cheng, Xiulian
AU  - Cheng X
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Zhengzhou 
      University Zhengzhou 450052, Henan Province, PR China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20180901
PL  - United States
TA  - Am J Cancer Res
JT  - American journal of cancer research
JID - 101549944
RIN - Am J Cancer Res. 2020 Nov 01;10(11):4016. PMID: 33294283
PMC - PMC6176179
OTO - NOTNLM
OT  - Hippo pathway
OT  - YAP1
OT  - miR-345
COIS- None.
EDAT- 2018/10/17 06:00
MHDA- 2018/10/17 06:01
PMCR- 2018/09/01
CRDT- 2018/10/17 06:00
PHST- 2018/07/22 00:00 [received]
PHST- 2018/07/30 00:00 [accepted]
PHST- 2018/10/17 06:00 [entrez]
PHST- 2018/10/17 06:00 [pubmed]
PHST- 2018/10/17 06:01 [medline]
PHST- 2018/09/01 00:00 [pmc-release]
PST - epublish
SO  - Am J Cancer Res. 2018 Sep 1;8(9):1712-1724. eCollection 2018.