PMID- 30325066
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20191104
IS  - 1554-527X (Electronic)
IS  - 0736-0266 (Linking)
VI  - 37
IP  - 1
DP  - 2019 Jan
TI  - Duration of symptoms is associated with conditioned pain modulation and 
      somatosensory measures in knee osteoarthritis.
PG  - 136-142
LID - 10.1002/jor.24159 [doi]
AB  - Impaired descending pain inhibition has been linked to chronic pain and poorer 
      patient outcomes. Vibration perception threshold (VPT) has also been observed and 
      linked to radiographic stage of OA. However, it is not known how duration of 
      symptoms may influence these neurophysiological measures. Our purpose was to 
      evaluate the relationship between duration of symptoms and conditioned pain 
      modulation (CPM), a measure of descending pain inhibition, and VPT, and to 
      determine whether these relationships differed in men and women seeking 
      orthopedic care. We evaluated 18 men and 27 women with moderate to severe knee 
      OA. We assessed CPM using a submaximal-effort tourniquet test: Pressure pain 
      threshold (PPT) at the symptomatic knee was evaluated before and after a noxious 
      stimulus. CPM impairment was indicated by a ratio of pre-to-post stimulus PPT >/=1. 
      VPT was assessed using a biothesiometer at the medial femoral condyle. We used 
      chi-square, t-tests and Pearson correlations to address study questions. 72% of 
      men, but only 44% of women had CPM impairment. Duration of symptoms was 
      associated with CPM impairment in women (R = 0.566, p = 0.003) but not men 
      (R = 0.366, p = 0.135). Duration of symptoms was also associated with VPT in both 
      men (R = 0.580, p = 0.012) and women (R = 0.406, p = 0.039). These results 
      suggest that longer duration of knee OA may predict more severe pain 
      sensitization and that important sex differences exist in descending pain 
      inhibition in people with chronic knee OA that may affect disease and course of 
      treatment in male and female patients. (c) 2018 Orthopaedic Research Society. 
      Published by Wiley Periodicals, Inc. J Orthop Res.
CI  - (c) 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
FAU - Foucher, Kharma C
AU  - Foucher KC
AD  - Department of Kinesiology and Nutrition, University of Illinois at Chicago, 
      Chicago, Illinois.
FAU - Chmell, Samuel J
AU  - Chmell SJ
AD  - Department of Orthopedic Surgery, University of Illinois at Chicago, Chicago, 
      Illinois.
FAU - Courtney, Carol A
AU  - Courtney CA
AD  - Department of Physical Therapy, University of Illinois at Chicago, Chicago, 
      Illinois.
LA  - eng
GR  - American Physical Therapy Association/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181101
PL  - United States
TA  - J Orthop Res
JT  - Journal of orthopaedic research : official publication of the Orthopaedic 
      Research Society
JID - 8404726
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*psychology
MH  - *Pain Perception
MH  - Sex Characteristics
MH  - Time Factors
OTO - NOTNLM
OT  - conditioned pain modulation
OT  - disease duration
OT  - knee osteoarthritis
OT  - pain processing
OT  - vibration perception
EDAT- 2018/10/17 06:00
MHDA- 2019/11/05 06:00
CRDT- 2018/10/17 06:00
PHST- 2018/04/23 00:00 [received]
PHST- 2018/09/12 00:00 [accepted]
PHST- 2018/10/17 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
PHST- 2018/10/17 06:00 [entrez]
AID - 10.1002/jor.24159 [doi]
PST - ppublish
SO  - J Orthop Res. 2019 Jan;37(1):136-142. doi: 10.1002/jor.24159. Epub 2018 Nov 1.