PMID- 30325303
OWN - NLM
STAT- MEDLINE
DCOM- 20190614
LR  - 20190614
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 37 Suppl 117
IP  - 2
DP  - 2019 Mar-Apr
TI  - Subclinical but significant liver fibrosis in patients with ANCA-associated 
      vasculitis.
PG  - 26-31
AB  - OBJECTIVES: We evaluated the laboratory and radiological data on liver and 
      investigate liver fibrosis induced by hepatic manifestation of antineutrophil 
      cytoplasmic antibody-associated vasculitis (AAV) using the aspartate 
      aminotransferase to platelet ratio index (APRI) and an index of fibrosis (FIB-4) 
      in 136 immunosuppressive drug-naive patients. METHODS: We retrospectively 
      reviewed the medical records of 136 patients with AAV without chronic liver 
      diseases or autoimmune diseases. We collected the laboratory and imaging results. 
      We assessed liver fibrosis by APRI and FIB-4. The critical cut-offs of APRI and 
      FIB-4 for predicting liver fibrosis are 0.5 and 1.45. The optimal cut-off of five 
      factor score (FFS) at diagnosis for FIB-4 >/=1.45 was extrapolated by the area 
      under the receiver operator characteristic curve. RESULTS: The mean age at 
      diagnosis was 54.6 years and 32.4% of patients were male (69 MPA, 38 GPA and 29 
      EGPA). The percentage of patients having the normal results of liver function 
      tests was ranging from 86.0% to 95.6%. There were no patients who exhibited the 
      significantly abnormal findings on imaging studies. Nonetheless, twenty-nine 
      patients with AAV (21.3%) exhibited subclinical but significant liver fibrosis at 
      diagnosis based on FIB-4. Patients with FFS >/=1 had a significantly higher risk of 
      having subclinical but significant liver fibrosis (FIB-4 >/=1.45) than those with 
      FFS <1 (RR 12.486). CONCLUSIONS: AAV may increase the results of liver function 
      tests and it may provoke subclinical but significant liver fibrosis at diagnosis. 
      Furthermore, liver fibrosis should be considered in AAV patients having FFS >/=1.
FAU - Lee, Sang-Won
AU  - Lee SW
AD  - Division of Rheumatology, Department of Internal Medicine, and Institute for 
      Immunology and Immunological Diseases, Yonsei University College of Medicine, 
      Seoul, Republic of Korea.
FAU - Kim, Do Young
AU  - Kim DY
AD  - Division of Gastroenterology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, and Yonsei Liver Center, Severance Hospital, Seoul, 
      Republic of Korea.
FAU - Ahn, Sang Hoon
AU  - Ahn SH
AD  - Division of Gastroenterology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, and Yonsei Liver Center, Severance Hospital, Seoul, 
      Republic of Korea.
FAU - Park, Yong-Beom
AU  - Park YB
AD  - Division of Rheumatology, Department of Internal Medicine, and Institute for 
      Immunology and Immunological Diseases, Yonsei University College of Medicine, 
      Seoul, Republic of Korea.
FAU - Han, Kwang-Hyub
AU  - Han KH
AD  - Division of Gastroenterology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, and Yonsei Liver Center, Severance Hospital, Seoul, 
      Republic of Korea.
FAU - Park, Jun Yong
AU  - Park JY
AD  - Division of Gastroenterology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, and Yonsei Liver Center, Severance Hospital, Seoul, 
      Republic of Korea. drpjy@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20181011
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Biomarkers)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
SB  - IM
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/complications/diagnosis
MH  - Aspartate Aminotransferases/*blood/metabolism
MH  - Biomarkers
MH  - Female
MH  - Humans
MH  - *Liver Cirrhosis/blood/diagnosis
MH  - Liver Function Tests
MH  - Male
MH  - Middle Aged
MH  - Platelet Count
MH  - Retrospective Studies
EDAT- 2018/10/17 06:00
MHDA- 2019/06/15 06:00
CRDT- 2018/10/17 06:00
PHST- 2018/03/13 00:00 [received]
PHST- 2018/05/14 00:00 [accepted]
PHST- 2018/10/17 06:00 [pubmed]
PHST- 2019/06/15 06:00 [medline]
PHST- 2018/10/17 06:00 [entrez]
AID - 12785 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2019 Mar-Apr;37 Suppl 117(2):26-31. Epub 2018 Oct 11.