PMID- 30326283
OWN - NLM
STAT- MEDLINE
DCOM- 20190729
LR  - 20190729
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 48
DP  - 2018 Dec
TI  - Exercise-induced brain-derived neurotrophic factor expression: Therapeutic 
      implications for Alzheimer's dementia.
PG  - 109-121
LID - S1568-1637(18)30044-8 [pii]
LID - 10.1016/j.arr.2018.10.002 [doi]
AB  - Emerging evidence indicates that moderate intensity aerobic exercise is 
      positively correlated with cognitive function and memory. However, the exact 
      mechanisms underlying such improvements remain unclear. Recent research in animal 
      models allows proposition of a pathway in which brain-derived neurotrophic factor 
      (BDNF) is a key mediator. This perspective draws upon evidence from animal and 
      human studies to highlight such a mechanism whereby exercise drives synthesis and 
      accumulation of neuroactive metabolites such as myokines and ketone bodies in the 
      periphery and in the hippocampus to enhance BDNF expression. BDNF is a 
      neurotrophin with well-established properties of promoting neuronal survival and 
      synaptic integrity, while its influence on energy transduction may provide the 
      crucial link between inherent vascular and metabolic benefits of exercise with 
      enhanced brain function. Indeed, BDNF mRNA and protein is robustly elevated in 
      rats following periods of voluntary exercise. This was also correlated with 
      improved spatial memory, while such benefits were abolished upon inhibition of 
      BDNF signaling. Similarly, both BDNF and cardiovascular fitness arising from 
      aerobic exercise have been positively associated with hippocampal volume and 
      function in humans. We postulate that exercise will attenuate cortical atrophy 
      and synaptic loss inherent to neurodegenerative disorders - many of which also 
      exhibit aberrant down-regulation of BDNF. Thus, the proposed link between BDNF, 
      exercise and cognition may have critical therapeutic implications for the 
      prevention and amelioration of memory loss and cognitive impairment in 
      Alzheimer's disease and associated dementias.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Wang, Rosy
AU  - Wang R
AD  - Laboratory of Molecular Neuroscience and Dementia, Brain and Mind Centre, The 
      University of Sydney, Camperdown, NSW, 2050 Australia.
FAU - Holsinger, R M Damian
AU  - Holsinger RMD
AD  - Laboratory of Molecular Neuroscience and Dementia, Brain and Mind Centre, The 
      University of Sydney, Camperdown, NSW, 2050 Australia; Discipline of Biomedical 
      Science, School of Medical Sciences, Sydney Medical School, The University of 
      Sydney, Lidcombe, NSW 1825 Australia. Electronic address: 
      Damian.Holsinger@sydney.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181013
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
RN  - 0 (Brain-Derived Neurotrophic Factor)
MH  - Alzheimer Disease/genetics/*metabolism/*therapy
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/genetics
MH  - Exercise/*physiology
MH  - Gene Expression
MH  - Hippocampus/metabolism/pathology
MH  - Humans
MH  - Physical Conditioning, Animal/physiology
OTO - NOTNLM
OT  - Cellular mechanisms
OT  - Cognition
OT  - Gene expression
OT  - Neurotrophins
OT  - Protein
OT  - mRNA
EDAT- 2018/10/17 06:00
MHDA- 2019/07/30 06:00
CRDT- 2018/10/17 06:00
PHST- 2018/02/23 00:00 [received]
PHST- 2018/09/26 00:00 [revised]
PHST- 2018/10/08 00:00 [accepted]
PHST- 2018/10/17 06:00 [pubmed]
PHST- 2019/07/30 06:00 [medline]
PHST- 2018/10/17 06:00 [entrez]
AID - S1568-1637(18)30044-8 [pii]
AID - 10.1016/j.arr.2018.10.002 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2018 Dec;48:109-121. doi: 10.1016/j.arr.2018.10.002. Epub 2018 
      Oct 13.