PMID- 30327181
OWN - NLM
STAT- MEDLINE
DCOM- 20181212
LR  - 20181212
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1578
DP  - 2018 Nov 30
TI  - The preparation of poly-levodopa coated capillary column for capillary 
      electrochromatography enantioseparation.
PG  - 91-98
LID - S0021-9673(18)31252-4 [pii]
LID - 10.1016/j.chroma.2018.10.007 [doi]
AB  - Levodopa (L-DOPA) is promising as chiral stationary phase for open tubular 
      capillary electrochromatography (OT-CEC) enantioseparation owing to its 
      self-polymerization adhesive property and chiral recognition potential. In this 
      work, CuSO(4)/H(2)O(2) was used as a trigger agent to accelerate the 
      polymerization process of L-DOPA and the poly-levodopa (poly-(L-DOPA)) coated 
      column was successfully prepared for the first time by depositing it on the inner 
      wall of fused silica capillary via the rapid and in-situ approach at room 
      temperature. The performance of the poly-(L-DOPA) coated capillary was validated 
      by the separation of different chiral analytes, including chiral amine drugs, 
      neurotransmitters and amino acids, and the good enantioseparation efficiencies 
      were achieved. For five consecutive runs, the relative standard deviations (RSDs) 
      for the migration time of the analytes for intra-day, inter-day and 
      column-to-column were in the range of 0.19-1.33%, 0.96-4.47%, and 2.21-7.79%, 
      respectively. Additionally, the poly-(L-DOPA) coated capillary column could be 
      successively used over 250 runs without observable change in the separation 
      efficiency.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Guo, Heying
AU  - Guo H
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Key Laboratory of Nonferrous Metal Chemistry and Resources 
      Utilization of Gansu Province, Lanzhou University, Lanzhou, 730000, China.
FAU - Sun, Yu
AU  - Sun Y
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Key Laboratory of Nonferrous Metal Chemistry and Resources 
      Utilization of Gansu Province, Lanzhou University, Lanzhou, 730000, China.
FAU - Niu, Xiaoying
AU  - Niu X
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Key Laboratory of Nonferrous Metal Chemistry and Resources 
      Utilization of Gansu Province, Lanzhou University, Lanzhou, 730000, China.
FAU - Wei, Nannan
AU  - Wei N
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Key Laboratory of Nonferrous Metal Chemistry and Resources 
      Utilization of Gansu Province, Lanzhou University, Lanzhou, 730000, China.
FAU - Pan, Congjie
AU  - Pan C
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Key Laboratory of Nonferrous Metal Chemistry and Resources 
      Utilization of Gansu Province, Lanzhou University, Lanzhou, 730000, China.
FAU - Wang, Guoxiu
AU  - Wang G
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Key Laboratory of Nonferrous Metal Chemistry and Resources 
      Utilization of Gansu Province, Lanzhou University, Lanzhou, 730000, China.
FAU - Zhang, Huige
AU  - Zhang H
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Key Laboratory of Nonferrous Metal Chemistry and Resources 
      Utilization of Gansu Province, Lanzhou University, Lanzhou, 730000, China.
FAU - Chen, Hongli
AU  - Chen H
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Key Laboratory of Nonferrous Metal Chemistry and Resources 
      Utilization of Gansu Province, Lanzhou University, Lanzhou, 730000, China. 
      Electronic address: hlchen@lzu.edu.cn.
FAU - Yi, Tao
AU  - Yi T
AD  - School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong 
      Special Administrative Region.
FAU - Chen, Xingguo
AU  - Chen X
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Key Laboratory of Nonferrous Metal Chemistry and Resources 
      Utilization of Gansu Province, Lanzhou University, Lanzhou, 730000, China.
LA  - eng
PT  - Journal Article
DEP - 20181009
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 46627O600J (Levodopa)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - LRX7AJ16DT (Copper Sulfate)
SB  - IM
MH  - Capillary Electrochromatography/*instrumentation
MH  - Chemistry Techniques, Analytical/*instrumentation/*methods
MH  - Copper Sulfate/chemistry
MH  - Hydrogen Peroxide/chemistry
MH  - Levodopa/*chemistry
MH  - Silicon Dioxide/chemistry
MH  - Stereoisomerism
OTO - NOTNLM
OT  - Enantioseparation
OT  - Open tubular capillary electrochromatography
OT  - Poly-levodopa
EDAT- 2018/10/18 06:00
MHDA- 2018/12/13 06:00
CRDT- 2018/10/18 06:00
PHST- 2018/08/11 00:00 [received]
PHST- 2018/10/04 00:00 [revised]
PHST- 2018/10/09 00:00 [accepted]
PHST- 2018/10/18 06:00 [pubmed]
PHST- 2018/12/13 06:00 [medline]
PHST- 2018/10/18 06:00 [entrez]
AID - S0021-9673(18)31252-4 [pii]
AID - 10.1016/j.chroma.2018.10.007 [doi]
PST - ppublish
SO  - J Chromatogr A. 2018 Nov 30;1578:91-98. doi: 10.1016/j.chroma.2018.10.007. Epub 
      2018 Oct 9.